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    CREM cAMP responsive element modulator [ Canis lupus familiaris (dog) ]

    Gene ID: 403887, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CREMprovided by VGNC
    Official Full Name
    cAMP responsive element modulatorprovided by VGNC
    Primary source
    VGNC:VGNC:52123
    See related
    Ensembl:ENSCAFG00845001664
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See CREM in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (2037957..2111330, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (1843669..1893973, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (1973934..2024249, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (1809553..1859860, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (1853133..1903529, complement)

    Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene cyclin Y Neighboring gene uncharacterized LOC119870079 Neighboring gene 40S ribosomal protein S6-like Neighboring gene uncharacterized LOC111091150 Neighboring gene axin interactor, dorsalization-associated protein-like Neighboring gene protein SGT1 homolog Neighboring gene cullin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dog CREM transcription factors: cloning, tissue distribution, and identification of new isoforms. Uyttersprot N, et al. Biochem Biophys Res Commun, 1997 Aug 8. PMID 9266832
    2. Molecular phylogenetics and the origins of placental mammals. Murphy WJ, et al. Nature, 2001 Feb 1. PMID 11214319
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ATF4-CREB1 transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cAMP-responsive element modulator
    Names
    cAMP responsive element moderator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003221.1 → NP_001003221.1  cAMP-responsive element modulator

      See identical proteins and their annotated locations for NP_001003221.1

      Status: PROVISIONAL

      Source sequence(s)
      X99115
      UniProtKB/TrEMBL
      A0A8C0JHE2
      Conserved Domains (2) summary
      cd14690
      Location:288 → 342
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:101 → 138
      pKID; pKID domain

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051806.1 Reference ROS_Cfam_1.0

      Range
      2037957..2111330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038657747.1 → XP_038513675.1  cAMP-responsive element modulator isoform X19

      Conserved Domains (2) summary
      cd14690
      Location:180 → 234
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:69 → 105
      pKID; pKID domain

    2. XM_038657745.1 → XP_038513673.1  cAMP-responsive element modulator isoform X17

      Conserved Domains (2) summary
      cd14690
      Location:192 → 246
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:69 → 105
      pKID; pKID domain

    3. XM_038657740.1 → XP_038513668.1  cAMP-responsive element modulator isoform X13

      UniProtKB/TrEMBL
      A0A8C0M6P8
      Conserved Domains (2) summary
      cd14690
      Location:229 → 283
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:118 → 154
      pKID; pKID domain

    4. XM_038657739.1 → XP_038513667.1  cAMP-responsive element modulator isoform X12

      UniProtKB/TrEMBL
      A0A8C0M6P8
      Conserved Domains (2) summary
      cd14690
      Location:241 → 295
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:118 → 154
      pKID; pKID domain

    5. XM_038657737.1 → XP_038513665.1  cAMP-responsive element modulator isoform X10

      UniProtKB/TrEMBL
      A0A8C0QT68
      Conserved Domains (2) summary
      cd14690
      Location:243 → 297
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:69 → 105
      pKID; pKID domain

    6. XM_038657729.1 → XP_038513657.1  cAMP-responsive element modulator isoform X3

      UniProtKB/TrEMBL
      A0A8C0JHE2
      Conserved Domains (2) summary
      cd14690
      Location:292 → 346
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:118 → 154
      pKID; pKID domain

    7. XM_038657734.1 → XP_038513662.1  cAMP-responsive element modulator isoform X7

      UniProtKB/TrEMBL
      A0A8C0QT68
      Conserved Domains (2) summary
      cd14690
      Location:255 → 309
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:69 → 105
      pKID; pKID domain

    8. XM_038657731.1 → XP_038513659.1  cAMP-responsive element modulator isoform X5

      UniProtKB/TrEMBL
      A0A8C0JHE2
      Conserved Domains (2) summary
      cd14690
      Location:288 → 342
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:102 → 138
      pKID; pKID domain

    9. XM_038657727.1 → XP_038513655.1  cAMP-responsive element modulator isoform X1

      UniProtKB/TrEMBL
      A0A8C0JHE2
      Conserved Domains (2) summary
      cd14690
      Location:304 → 358
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:118 → 154
      pKID; pKID domain

    10. XM_038657749.1 → XP_038513677.1  cAMP-responsive element modulator isoform X21

      UniProtKB/TrEMBL
      A0A8C0JL10
      Conserved Domains (2) summary
      cd14690
      Location:149 → 203
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:38 → 74
      pKID; pKID domain

    11. XM_038657742.1 → XP_038513670.1  cAMP-responsive element modulator isoform X15

      UniProtKB/TrEMBL
      A0A8C0JHK9
      Conserved Domains (2) summary
      cd14690
      Location:212 → 266
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:38 → 74
      pKID; pKID domain

    12. XM_038657741.1 → XP_038513669.1  cAMP-responsive element modulator isoform X14

      UniProtKB/TrEMBL
      A0A8C0Q3A4, A0A8C0QT68, A0A8I3RRT1
      Related
      ENSCAFP00845002619.1, ENSCAFT00845003302.1
      Conserved Domains (2) summary
      cd14690
      Location:224 → 278
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:38 → 74
      pKID; pKID domain

    13. XM_038657732.1 → XP_038513660.1  cAMP-responsive element modulator isoform X6

      UniProtKB/TrEMBL
      A0A8C0JHE2
      Conserved Domains (2) summary
      cd14690
      Location:273 → 327
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:87 → 123
      pKID; pKID domain

    14. XM_038657736.1 → XP_038513664.1  cAMP-responsive element modulator isoform X9

      UniProtKB/TrEMBL
      A0A8C0JHE2
      Conserved Domains (2) summary
      cd14690
      Location:249 → 303
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:63 → 99
      pKID; pKID domain

    15. XM_038657743.1 → XP_038513671.1  cAMP-responsive element modulator isoform X16

      UniProtKB/TrEMBL
      A0A8C0QT68
      Conserved Domains (2) summary
      cd14690
      Location:200 → 254
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:14 → 50
      pKID; pKID domain

    16. XM_038657752.1 → XP_038513680.1  cAMP-responsive element modulator isoform X24

      UniProtKB/TrEMBL
      A0A8P0P8W7
      Conserved Domains (1) summary
      cd14690
      Location:57 → 111
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    17. XM_038657750.1 → XP_038513678.1  cAMP-responsive element modulator isoform X22

      UniProtKB/TrEMBL
      A0A8C0M704, A0A8I3MJ55
      Conserved Domains (1) summary
      cd14690
      Location:69 → 123
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    18. XM_038657757.1 → XP_038513685.1  cAMP-responsive element modulator isoform X28

      UniProtKB/TrEMBL
      A0A8P0P8W7
      Conserved Domains (1) summary
      cd14690
      Location:39 → 93
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    19. XM_038657754.1 → XP_038513682.1  cAMP-responsive element modulator isoform X26

      UniProtKB/TrEMBL
      A0A8P0P8W7
      Conserved Domains (1) summary
      cd14690
      Location:46 → 100
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    20. XM_038657756.1 → XP_038513684.1  cAMP-responsive element modulator isoform X27

      UniProtKB/TrEMBL
      A0A8P0P8W7
      Conserved Domains (1) summary
      cd14690
      Location:46 → 100
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    21. XM_038657728.1 → XP_038513656.1  cAMP-responsive element modulator isoform X2

      UniProtKB/Swiss-Prot
      P79145
      UniProtKB/TrEMBL
      A0A8C0JHE2
      Related
      ENSCAFP00845002571.1, ENSCAFT00845003241.1
      Conserved Domains (2) summary
      cd14690
      Location:304 → 358
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:118 → 154
      pKID; pKID domain

    22. XM_038657748.1 → XP_038513676.1  cAMP-responsive element modulator isoform X20

      UniProtKB/TrEMBL
      A0A8C0M6P8, A0A8I3N049, A0A8P0PC73
      Related
      ENSCAFP00845002581.1, ENSCAFT00845003254.1
      Conserved Domains (2) summary
      cd14690
      Location:180 → 234
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:69 → 105
      pKID; pKID domain

    23. XM_038657746.1 → XP_038513674.1  cAMP-responsive element modulator isoform X18

      UniProtKB/TrEMBL
      A0A8C0M6P8, A0A8C0PM92, A0A8I3MIZ8
      Related
      ENSCAFP00845002577.1, ENSCAFT00845003249.1
      Conserved Domains (2) summary
      cd14690
      Location:192 → 246
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:69 → 105
      pKID; pKID domain

    24. XM_038657738.1 → XP_038513666.1  cAMP-responsive element modulator isoform X11

      UniProtKB/TrEMBL
      A0A8C0QT68, A0A8C0RUS7, A0A8I3RQ88
      Related
      ENSCAFP00845002572.1, ENSCAFT00845003243.1
      Conserved Domains (2) summary
      cd14690
      Location:243 → 297
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:69 → 105
      pKID; pKID domain

    25. XM_038657730.1 → XP_038513658.1  cAMP-responsive element modulator isoform X4

      UniProtKB/TrEMBL
      A0A8C0JHE2
      Conserved Domains (2) summary
      cd14690
      Location:292 → 346
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:118 → 154
      pKID; pKID domain

    26. XM_038657735.1 → XP_038513663.1  cAMP-responsive element modulator isoform X8

      UniProtKB/TrEMBL
      A0A8C0QT68
      Conserved Domains (2) summary
      cd14690
      Location:255 → 309
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:69 → 105
      pKID; pKID domain

    27. XM_038657753.1 → XP_038513681.1  cAMP-responsive element modulator isoform X25

      UniProtKB/TrEMBL
      A0A8C0PLB2, A0A8P0P8W7
      Conserved Domains (1) summary
      cd14690
      Location:57 → 111
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    28. XM_038657751.1 → XP_038513679.1  cAMP-responsive element modulator isoform X23

      UniProtKB/TrEMBL
      A0A8C0M704, A0A8I3MJ55
      Related
      ENSCAFP00845002392.1, ENSCAFT00845003000.1
      Conserved Domains (1) summary
      cd14690
      Location:69 → 123
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049262.1 Alternate UMICH_Zoey_3.1

      Range
      1809553..1859860 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

      Range
      1853133..1903529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

      Range
      1973934..2024249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      1843669..1893973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P79145.2 GenPept UniProtKB/Swiss-Prot:P79145

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