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    Slc9b1 solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 74446, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slc9b1provided by MGI
    Official Full Name
    solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1provided by MGI
    Primary source
    MGI:MGI:1921696
    See related
    Ensembl:ENSMUSG00000050150 AllianceGenome:MGI:1921696
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nhedc1; mtsNHE; 1700094G20Rik; 4933424B12Rik; 4933425K02Rik
    Summary
    Predicted to enable antiporter activity. Involved in flagellated sperm motility and regulation of intracellular pH. Located in sperm principal piece. Orthologous to human SLC9B1 (solute carrier family 9 member B1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 25.1) See more
    Orthologs
    human all
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    Genomic context

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    See Slc9b1 in Genome Data Viewer
    Location:
    3 G3; 3 62.55 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (135053754..135103588)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (135347993..135397827)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46826 Neighboring gene 3-hydroxybutyrate dehydrogenase, type 2 Neighboring gene STARR-seq mESC enhancer starr_09056 Neighboring gene solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 Neighboring gene STARR-seq mESC enhancer starr_09057 Neighboring gene STARR-seq mESC enhancer starr_09058 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:135065430-135065659 Neighboring gene CDGSH iron sulfur domain 2 Neighboring gene RIKEN cDNA 4930539J05 gene Neighboring gene STARR-positive B cell enhancer ABC_E1026 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:135101299-135101408 Neighboring gene ubiquitin-conjugating enzyme E2D 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Evolution of Vertebrate Solute Carrier Family 9B Genes and Proteins (SLC9B): Evidence for a Marsupial Origin for Testis Specific SLC9B1 from an Ancestral Vertebrate SLC9B2 Gene. Holmes RS, et al. J Phylogenetics Evol Biol, 2016 Aug. PMID 28868326, Free PMC Article
    2. Immunization with a DNA vaccine of testis-specific sodium-hydrogen exchanger by oral feeding or nasal instillation reduces fertility in female mice. Liu T, et al. Fertil Steril, 2010 Mar 15. PMID 19409551
    3. A novel testis-specific Na+/H+ exchanger is involved in sperm motility and fertility. Liu T, et al. Front Biosci (Elite Ed), 2010 Jan 1. PMID 20036903
    4. Sodium-hydrogen exchanger NHA1 and NHA2 control sperm motility and male fertility. Chen SR, et al. Cell Death Dis, 2016 Mar 24. PMID 27010853, Free PMC Article
    5. Molecular Mechanism Underlying the Action of Zona-pellucida Glycoproteins on Mouse Sperm. Balbach M, et al. Front Cell Dev Biol, 2020. PMID 32984353, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data revealed that NHA1 and NHA2 function as a key sodium-hydrogen exchanger responsible for sperm motility after leaving the cauda epididymidis.
      Title: Sodium-hydrogen exchanger NHA1 and NHA2 control sperm motility and male fertility.
    2. A novel testis-specific Na+/H+ exchanger, mtsNHE, is involved in sperm motility and fertility.
      Title: A novel testis-specific Na+/H+ exchanger is involved in sperm motility and fertility.
    3. Immunization with a DNA vaccine of testis-specific sodium-hydrogen exchanger (tsNHE) via oral feeding or nasal instillation reduced fertility in female mice.
      Title: Immunization with a DNA vaccine of testis-specific sodium-hydrogen exchanger by oral feeding or nasal instillation reduces fertility in female mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inorganic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intracellular pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in single fertilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm principal piece IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sodium/hydrogen exchanger 9B1
    Names
    NHE domain-containing protein 1
    Na(+)/H(+) exchanger-like domain-containing protein 1
    Na+/H+ exchanger domain containing 1
    sodium/hydrogen exchanger-like domain-containing protein 1
    solute carrier family 9 subfamily B member 1
    testis specific sodium-hydrogen exchanger

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358057.1 → NP_001344986.1  sodium/hydrogen exchanger 9B1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC104874, AK016917
      Related
      ENSMUST00000160460.8
      Conserved Domains (1) summary
      cl01133
      Location:207 → 355
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    2. NM_028946.4 → NP_083222.2  sodium/hydrogen exchanger 9B1 isoform 1

      See identical proteins and their annotated locations for NP_083222.2

      Status: VALIDATED

      Source sequence(s)
      AC156618, AK029525, AV262918, BX525256
      Consensus CDS
      CCDS17855.2
      UniProtKB/Swiss-Prot
      B5AFL0, Q8C0X2, Q8C1I8, Q8R3N0, Q9CPR9, Q9D400
      UniProtKB/TrEMBL
      G5E8I2
      Related
      ENSMUSP00000077644.6, ENSMUST00000078568.12
      Conserved Domains (1) summary
      cl01133
      Location:207 → 551
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      135053754..135103588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240253.3 → XP_011238555.1  sodium/hydrogen exchanger 9B1 isoform X3

      Conserved Domains (1) summary
      cl01133
      Location:207 → 269
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    2. XM_017319776.1 → XP_017175265.1  sodium/hydrogen exchanger 9B1 isoform X1

      UniProtKB/Swiss-Prot
      B5AFL0, Q8C0X2, Q8C1I8, Q8R3N0, Q9CPR9, Q9D400
      UniProtKB/TrEMBL
      G5E8I2
      Conserved Domains (1) summary
      cl01133
      Location:207 → 551
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    3. XM_017319775.1 → XP_017175264.1  sodium/hydrogen exchanger 9B1 isoform X1

      UniProtKB/Swiss-Prot
      B5AFL0, Q8C0X2, Q8C1I8, Q8R3N0, Q9CPR9, Q9D400
      UniProtKB/TrEMBL
      G5E8I2
      Conserved Domains (1) summary
      cl01133
      Location:207 → 551
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    4. XM_011240251.2 → XP_011238553.1  sodium/hydrogen exchanger 9B1 isoform X1

      See identical proteins and their annotated locations for XP_011238553.1

      UniProtKB/Swiss-Prot
      B5AFL0, Q8C0X2, Q8C1I8, Q8R3N0, Q9CPR9, Q9D400
      UniProtKB/TrEMBL
      G5E8I2
      Conserved Domains (1) summary
      cl01133
      Location:207 → 551
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    5. XM_006502201.3 → XP_006502264.1  sodium/hydrogen exchanger 9B1 isoform X1

      See identical proteins and their annotated locations for XP_006502264.1

      UniProtKB/Swiss-Prot
      B5AFL0, Q8C0X2, Q8C1I8, Q8R3N0, Q9CPR9, Q9D400
      UniProtKB/TrEMBL
      G5E8I2
      Conserved Domains (1) summary
      cl01133
      Location:207 → 551
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    6. XM_011240252.2 → XP_011238554.1  sodium/hydrogen exchanger 9B1 isoform X2

      Conserved Domains (1) summary
      cl01133
      Location:207 → 400
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    RNA

    1. XR_867240.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0X2.1 GenPept UniProtKB/Swiss-Prot:Q8C0X2

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