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    NAIP NLR family apoptosis inhibitory protein [ Pteropus vampyrus (large flying fox) ]

    Gene ID: 105300504, updated on 19-Jun-2024

    Summary

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    Gene symbol
    NAIP
    Gene description
    NLR family apoptosis inhibitory protein
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pteropus vampyrus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yinpterochiroptera; Pteropodoidea; Pteropodidae; Pteropodinae; Pteropus
    Orthologs
    human all
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    Genomic context

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    See NAIP in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    101 current Pvam_2.0 (GCF_000151845.1) Unplaced Scaffold NW_011888994.1 (2649895..2676053, complement)

    NW_011888994.1Genomic Context describing neighboring genes Neighboring gene small EDRK-rich factor 1 Neighboring gene survival motor neuron protein Neighboring gene general transcription factor IIH subunit 2 Neighboring gene 5S ribosomal RNA Neighboring gene occludin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_011888994 Unplaced Scaffold Reference Pvam_2.0

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in detection of bacterium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in pyroptotic inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of IPAF inflammasome complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Pteropus vampyrus Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Pvam_2.0

    Genomic

    1. NW_011888994.1 Reference Pvam_2.0

      Range
      2649895..2676053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011372742.2 → XP_011371044.1  LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 1

      UniProtKB/TrEMBL
      A0A6P3QWF5
      Conserved Domains (8) summary
      smart00238
      Location:277 → 352
      BIR; Baculoviral inhibition of apoptosis protein repeat
      smart00382
      Location:468 → 595
      AAA; ATPases associated with a variety of cellular activities
      cd00022
      Location:61 → 129
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00116
      Location:1232 → 1382
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:1108 → 1133
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1160 → 1185
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam00653
      Location:162 → 228
      BIR; Inhibitor of Apoptosis domain
      pfam05729
      Location:469 → 622
      NACHT; NACHT domain
    Nucleotide Protein
    Heading Accession and Version

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