GPR174 G protein-coupled receptor 174 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GPR174provided by HGNC
Official Full Name: G protein-coupled receptor 174provided by HGNC
Primary source: HGNC:HGNC:30245
See related: Ensembl:ENSG00000147138 MIM:300903; AllianceGenome:HGNC:30245
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LPS3; FKSG79; GPCR17; LYPSR3
Summary: This gene encodes a protein belonging to the G protein-coupled receptor superfamily. These proteins are characterized by the presence of seven alpha-helical transmembrane domains, and they activate or interact with various endogenous or exogenous ligands, including neurotransmitters, hormones, and odorant and taste substances. This family member is classified as an orphan receptor because the cognate ligand has not been identified. [provided by RefSeq, Sep 2011]
Orthologs: mouse all
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Genomic context

Location:: Xq21.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (79144688..79175318)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (77581427..77612052)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (78400185..78430815)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174.
Title: Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174.
Gpr174 Knockout Alleviates DSS-Induced Colitis via Regulating the Immune Function of Dendritic Cells.
Title: Gpr174 Knockout Alleviates DSS-Induced Colitis via Regulating the Immune Function of Dendritic Cells.
GPR174 mRNA Acts as a Novel Prognostic Biomarker for Patients With Sepsis via Regulating the Inflammatory Response.
Title: GPR174 mRNA Acts as a Novel Prognostic Biomarker for Patients With Sepsis via Regulating the Inflammatory Response.
GPR174 and ITM2A Gene Polymorphisms rs3827440 and rs5912838 on the X chromosome in Korean Children with Autoimmune Thyroid Disease.
Title: GPR174 and ITM2A Gene Polymorphisms rs3827440 and rs5912838 on the X chromosome in Korean Children with Autoimmune Thyroid Disease.
Studied association of and RNASET2, GPR174, and PTPN22 gene polymorphisms and liver damage(LD) due to Graves' disease (GD) hyperthyroidism. Found GPR174 rs3827440, PTPN22 rs3789604, and RNASET2 rs9355610 were significantly associated with altered GD-derived LD risk.
Title: RNASET2, GPR174, and PTPN22 gene polymorphisms are related to the risk of liver damage associated with the hyperthyroidism in patients with Graves' disease.
Alteration of gene expression profiling including GPR174 and GNG2 is associated with vasovagal syncope.
Title: Alteration of gene expression profiling including GPR174 and GNG2 is associated with vasovagal syncope.
We have demonstrated a significant association of this X chromosome-encoded immunoreceptor with autoimmune Addison's disease for the first time.
Title: Role of the X-linked gene GPR174 in autoimmune Addison's disease.
this study provides the first replication in a Caucasian population of the association between Graves' disease and the GPR174 rs3827440 single nucleotide polymorphism originally reported among Chinese.
Title: rs3827440, a nonsynonymous single nucleotide polymorphism within GPR174 gene in X chromosome, is associated with Graves' disease in Polish Caucasian population.
The finding of an X-linked risk locus for Graves' disease expands our understanding of the role of the X chromosome in disease susceptibility.
Title: An X chromosome-wide association analysis identifies variants in GPR174 as a risk factor for Graves' disease.
These results suggested that GPR174 was a putative LysoPS receptor conjugating with Galpha(s), and its expression induced morphological changes in CHO cells by constitutively activating adenylyl cycles accompanied with cell conjunctions and delay of proliferation.
Title: Expression of orphan G-protein coupled receptor GPR174 in CHO cells induced morphological changes and proliferation delay via increasing intracellular cAMP.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

DXS8082 (e-PCR)
- UniSTS:69888

NoName (e-PCR)
- UniSTS:483457

FKSG79__6728 (e-PCR)
- UniSTS:468418

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables bioactive lipid receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in T cell homeostasis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-2 production	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in centriolar satellite	IDA Inferred from Direct Assay more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: probable G-protein coupled receptor 174

Names: lysophosphatidylserine receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016565.2 RefSeqGene

Range

5001..9347

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_032553.3 → NP_115942.1 probable G-protein coupled receptor 174

See identical proteins and their annotated locations for NP_115942.1

Status: VALIDATED

Source sequence(s)

AL590222

Consensus CDS

CCDS14443.1

UniProtKB/Swiss-Prot

Q2M3F7, Q9BXC1

Related

ENSP00000494310.1, ENST00000645147.2

Conserved Domains (1) summary

pfam00001
Location:36 → 292

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000023.11 Reference GRCh38.p14 Primary Assembly

Range

79144688..79175318

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047442580.1 → XP_047298536.1 probable G-protein coupled receptor 174 isoform X1

UniProtKB/Swiss-Prot

Q2M3F7, Q9BXC1
XM_047442579.1 → XP_047298535.1 probable G-protein coupled receptor 174 isoform X1

UniProtKB/Swiss-Prot

Q2M3F7, Q9BXC1

Alternate T2T-CHM13v2.0

Genomic

NC_060947.1 Alternate T2T-CHM13v2.0

Range

77581427..77612052

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054327992.1 → XP_054183967.1 probable G-protein coupled receptor 174 isoform X1
XM_054327991.1 → XP_054183966.1 probable G-protein coupled receptor 174 isoform X1