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    OGFRL1 opioid growth factor receptor like 1 [ Homo sapiens (human) ]

    Gene ID: 79627, updated on 2-Nov-2024

    Summary

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    Official Symbol
    OGFRL1provided by HGNC
    Official Full Name
    opioid growth factor receptor like 1provided by HGNC
    Primary source
    HGNC:HGNC:21378
    See related
    Ensembl:ENSG00000119900 AllianceGenome:HGNC:21378
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    dJ331H24.1
    Summary
    Predicted to enable opioid growth factor receptor activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 22.5), esophagus (RPKM 15.1) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See OGFRL1 in Genome Data Viewer
    Location:
    6q13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (71288811..71309059)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (72469249..72489496)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (71998514..72018762)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901338 Neighboring gene uncharacterized LOC124901339 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:71961178-71961445 Neighboring gene coiled-coil domain containing 112 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17326 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:72077050-72078249 Neighboring gene origin of replication 343 Neighboring gene microRNA 30c-2 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:72111792-72112320 Neighboring gene microRNA 30a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Exclusion of four candidate genes, KHDRBS2, PTP4A1, KIAA1411 and OGFRL1, as causative of autosomal recessive retinitis pigmentosa. Abd El-Aziz MM, et al. Ophthalmic Res, 2006. PMID 16192744
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    3. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21079, MGC102783

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables opioid growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    opioid growth factor receptor-like protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324266.2 → NP_001311195.1  opioid growth factor receptor-like protein 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AI800853, AK124833, AK308623, AL137346, BC018688, BX379107, BX420584, BX488500, CK819012, DA151056, DA330565, DA852679
      UniProtKB/Swiss-Prot
      Q5TC84
      Conserved Domains (2) summary
      pfam04664
      Location:114 → 320
      OGFr_N; Opioid growth factor receptor (OGFr) conserved region
      cl15483
      Location:254 → 434
      Hid1; High-temperature-induced dauer-formation protein

    2. NM_024576.5 → NP_078852.3  opioid growth factor receptor-like protein 1 isoform b

      See identical proteins and their annotated locations for NP_078852.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a.
      Source sequence(s)
      AI800853, AK124833, AK308623, AL137346, BC018688, BX488500, CK819012, DA151056, DA330565, DA852679
      Consensus CDS
      CCDS34482.1
      UniProtKB/Swiss-Prot
      Q2TAC1, Q5TC84, Q8NEQ4, Q9H7B5
      Related
      ENSP00000359464.3, ENST00000370435.5
      Conserved Domains (2) summary
      pfam04664
      Location:113 → 319
      OGFr_N; Opioid growth factor receptor (OGFr) conserved region
      cl15483
      Location:253 → 433
      Hid1; High-temperature-induced dauer-formation protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      71288811..71309059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419365.1 → XP_047275321.1  opioid growth factor receptor-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A3B3IRI0
      Related
      ENSP00000496790.1, ENST00000650315.1

    2. XM_017011305.3 → XP_016866794.1  opioid growth factor receptor-like protein 1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      72469249..72489496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356435.1 → XP_054212410.1  opioid growth factor receptor-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A3B3IRI0

    2. XM_054356431.1 → XP_054212406.1  opioid growth factor receptor-like protein 1 isoform X1

    3. XM_054356436.1 → XP_054212411.1  opioid growth factor receptor-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A3B3IRI0

    4. XM_054356432.1 → XP_054212407.1  opioid growth factor receptor-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A3B3IRI0

    5. XM_054356433.1 → XP_054212408.1  opioid growth factor receptor-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A3B3IRI0

    6. XM_054356434.1 → XP_054212409.1  opioid growth factor receptor-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A3B3IRI0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5TC84.1 GenPept UniProtKB/Swiss-Prot:Q5TC84

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