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    TCEAL9 transcription elongation factor A like 9 [ Homo sapiens (human) ]

    Gene ID: 51186, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TCEAL9provided by HGNC
    Official Full Name
    transcription elongation factor A like 9provided by HGNC
    Primary source
    HGNC:HGNC:30084
    See related
    Ensembl:ENSG00000185222 AllianceGenome:HGNC:30084
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WBP5; WEX6
    Summary
    The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein. This gene also encodes a domain with similarity to the transcription elongation factor A, SII-related family. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in placenta (RPKM 88.8), ovary (RPKM 84.9) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TCEAL9 in Genome Data Viewer
    Location:
    Xq22.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (103356506..103358462)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (101803512..101805468)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (102611434..102613390)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:102585683-102586182 Neighboring gene brain expressed X-linked 2 Neighboring gene transcription elongation factor A like 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:102603213-102603753 Neighboring gene uncharacterized LOC124905204 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:102610887-102612086 Neighboring gene uncharacterized LL0XNC01-250H12.3 Neighboring gene brain expressed X-linked 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29817 Neighboring gene MPRA-validated peak7415 silencer Neighboring gene NANOG hESC enhancer GRCh37_chrX:102679147-102679648 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:102689981-102690482 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:102690483-102690982 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:102695365-102696050 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:102696051-102696737 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:102715105-102715604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29819 Neighboring gene RAB40A, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. High WBP5 expression correlates with elevation of HOX genes levels and is associated with inferior survival in patients with acute myeloid leukaemia. Ward C, et al. Sci Rep, 2020 Feb 26. PMID 32103106, Free PMC Article
    2. WW domain binding protein 5 induces multidrug resistance of small cell lung cancer under the regulation of miR-335 through the Hippo pathway. Tang R, et al. Br J Cancer, 2016 Jul 12. PMID 27336605, Free PMC Article
    3. FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands. Bedford MT, et al. EMBO J, 1997 May 1. PMID 9171351, Free PMC Article
    4. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. Winter EE, et al. BMC Evol Biol, 2005 Oct 12. PMID 16221301, Free PMC Article
    5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. Hu RM, et al. Proc Natl Acad Sci U S A, 2000 Aug 15. PMID 10931946, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High WBP5 expression correlates with elevation of HOX genes levels and is associated with inferior survival in patients with acute myeloid leukaemia.
      Title: High WBP5 expression correlates with elevation of HOX genes levels and is associated with inferior survival in patients with acute myeloid leukaemia.
    2. WW domain binding protein 5 can modulate MDR through the Hippo pathway under the regulation of miR-335. WW domain binding protein 5 may be a prognostic predictor and a potential target for interfering with MDR in SCLC.
      Title: WW domain binding protein 5 induces multidrug resistance of small cell lung cancer under the regulation of miR-335 through the Hippo pathway.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp313K1940

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription elongation factor A protein-like 9
    Names
    TCEA-like protein 9
    WBP-5
    WW domain binding protein 1
    WW domain-binding protein 5
    pp21 homolog
    transcription elongation factor S-II protein-like 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006612.2 → NP_001006613.1  transcription elongation factor A protein-like 9

      See identical proteins and their annotated locations for NP_001006613.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same isoform.
      Source sequence(s)
      BC023544, BG400091
      Consensus CDS
      CCDS14507.1
      UniProtKB/Swiss-Prot
      B2R5H6, Q9UHQ7
      Conserved Domains (1) summary
      pfam04538
      Location:2 → 102
      BEX; Brain expressed X-linked like family

    2. NM_001006613.2 → NP_001006614.1  transcription elongation factor A protein-like 9

      See identical proteins and their annotated locations for NP_001006614.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same isoform.
      Source sequence(s)
      BC023544, BG400091
      Consensus CDS
      CCDS14507.1
      UniProtKB/Swiss-Prot
      B2R5H6, Q9UHQ7
      Related
      ENSP00000361740.3, ENST00000372656.5
      Conserved Domains (1) summary
      pfam04538
      Location:2 → 102
      BEX; Brain expressed X-linked like family

    3. NM_001006614.2 → NP_001006615.1  transcription elongation factor A protein-like 9

      See identical proteins and their annotated locations for NP_001006615.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same isoform.
      Source sequence(s)
      BC023544, BG400091
      Consensus CDS
      CCDS14507.1
      UniProtKB/Swiss-Prot
      B2R5H6, Q9UHQ7
      Conserved Domains (1) summary
      pfam04538
      Location:2 → 102
      BEX; Brain expressed X-linked like family

    4. NM_016303.3 → NP_057387.1  transcription elongation factor A protein-like 9

      See identical proteins and their annotated locations for NP_057387.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 through 4 encode the same isoform.
      Source sequence(s)
      BC023544, BG400091
      Consensus CDS
      CCDS14507.1
      UniProtKB/Swiss-Prot
      B2R5H6, Q9UHQ7
      Related
      ENSP00000361745.3, ENST00000372661.6
      Conserved Domains (1) summary
      pfam04538
      Location:2 → 102
      BEX; Brain expressed X-linked like family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      103356506..103358462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      101803512..101805468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UHQ7.1 GenPept UniProtKB/Swiss-Prot:Q9UHQ7

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