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    AARSD1 alanyl-tRNA synthetase domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 80755, updated on 2-Nov-2024

    Summary

    Official Symbol
    AARSD1provided by HGNC
    Official Full Name
    alanyl-tRNA synthetase domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:28417
    See related
    Ensembl:ENSG00000266967 MIM:613212; AllianceGenome:HGNC:28417
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AlaXp
    Summary
    Predicted to enable Ser-tRNA(Ala) hydrolase activity. Predicted to be involved in regulation of translational fidelity. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 38.9), brain (RPKM 14.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See AARSD1 in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (42950526..42964454, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (43807669..43821595, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41102543..41116471, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RNY4 pseudogene 2 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene PTGES3L-AARSD1 readthrough Neighboring gene MPRA-validated peak2851 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:41124646-41125212 Neighboring gene prostaglandin E synthase 3 like Neighboring gene MPRA-validated peak2852 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8549 Neighboring gene RUN domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41142673-41143174 Neighboring gene uncharacterized LOC124904006

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef AARSD1 mRNA is selectively retained in HIV-1 Nef-expressing cellular exosomes, and three miRNAs (miR-16, miR-30c, and miR-30e*) which target AARSD1 mRNA are selectively secreted in exosomes from these cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC2744

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Ser-tRNA(Ala) hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables alanine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in alanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in regulation of translational fidelity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus HDA PubMed 

    General protein information

    Preferred Names
    alanyl-tRNA editing protein Aarsd1
    Names
    alanyl-tRNA synthetase domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261434.2NP_001248363.1  alanyl-tRNA editing protein Aarsd1

      See identical proteins and their annotated locations for NP_001248363.1

      Status: VALIDATED

      Source sequence(s)
      AC055866, AL515977, AW296090, BP368900
      Consensus CDS
      CCDS58552.1
      UniProtKB/Swiss-Prot
      B4DI73, Q9BTE6
      UniProtKB/TrEMBL
      C9J5N1
      Related
      ENSP00000400870.1, ENST00000427569.7
      Conserved Domains (2) summary
      COG2872
      Location:8248
      AlaX; Ser-tRNA(Ala) deacylase AlaX (editing enzyme) [Translation, ribosomal structure and biogenesis]
      cl08469
      Location:40236
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      42950526..42964454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      43807669..43821595 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)