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    ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [ Homo sapiens (human) ]

    Gene ID: 23527, updated on 3-Nov-2024

    Summary

    Official Symbol
    ACAP2provided by HGNC
    Official Full Name
    ArfGAP with coiled-coil, ankyrin repeat and PH domains 2provided by HGNC
    Primary source
    HGNC:HGNC:16469
    See related
    Ensembl:ENSG00000114331 MIM:607766; AllianceGenome:HGNC:16469
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CENTB2; CNT-B2
    Summary
    Enables GTPase activator activity. Acts upstream of or within actin filament-based process. Located in ruffle. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 13.3), lymph node (RPKM 12.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ACAP2 in Genome Data Viewer
    Location:
    3q29
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (195274745..195443020, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (197972626..198140907, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (194995474..195163749, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene xyloside xylosyltransferase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:194947105-194947699 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194960771-194961333 Neighboring gene RNA, U6 small nuclear 25, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21053 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:194974283-194975070 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:194976828-194977002 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15032 Neighboring gene uncharacterized LOC124909475 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:194991127-194991918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15035 Neighboring gene ribosomal protein L31 pseudogene 22 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21054 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:195154512-195155012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21055 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15036 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:195163293-195163792 Neighboring gene uncharacterized LOC124906341 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:195190192-195191391 Neighboring gene MPRA-validated peak4984 silencer Neighboring gene RNA, U6atac small nuclear 24, pseudogene Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0041

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament-based process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to nerve growth factor stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endocytic recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane HDA PubMed 
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
    Names
    Arf GAP with coiled coil, ANK repeat and PH domains 2
    centaurin-beta-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012287.6NP_036419.3  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

      See identical proteins and their annotated locations for NP_036419.3

      Status: VALIDATED

      Source sequence(s)
      AC090018, BC017120, CA413842, D26069, DB087306
      Consensus CDS
      CCDS33924.1
      UniProtKB/Swiss-Prot
      A8K2V4, Q15057, Q8N5Z8, Q9UQR3
      Related
      ENSP00000324287.6, ENST00000326793.11
      Conserved Domains (5) summary
      PTZ00322
      Location:642726
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:18217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      cd13250
      Location:269365
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:638671
      ANK; ANK repeat [structural motif]
      cd08851
      Location:399513
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      195274745..195443020 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512603.3XP_011510905.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X5

      See identical proteins and their annotated locations for XP_011510905.1

      Conserved Domains (6) summary
      PTZ00322
      Location:677761
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:18217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      COG5347
      Location:387631
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd13250
      Location:269365
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:673706
      ANK; ANK repeat [structural motif]
      cd08851
      Location:399513
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
    2. XM_006713557.4XP_006713620.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X9

      See identical proteins and their annotated locations for XP_006713620.1

      Conserved Domains (5) summary
      PTZ00322
      Location:649733
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:18217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      cd13250
      Location:269372
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:645678
      ANK; ANK repeat [structural motif]
      cd08851
      Location:406520
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
    3. XM_011512602.3XP_011510904.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X4

      See identical proteins and their annotated locations for XP_011510904.1

      Conserved Domains (6) summary
      PTZ00322
      Location:684768
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07638
      Location:18217
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      COG5347
      Location:394638
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd13250
      Location:269372
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:680713
      ANK; ANK repeat [structural motif]
      cd08851
      Location:406520
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
    4. XM_017006049.2XP_016861538.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X7

      Conserved Domains (5) summary
      PTZ00322
      Location:670754
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd13250
      Location:297393
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:666699
      ANK; ANK repeat [structural motif]
      cd08851
      Location:427541
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      cl12013
      Location:18245
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    5. XM_017006047.2XP_016861536.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X3

      Conserved Domains (6) summary
      PTZ00322
      Location:705789
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      COG5347
      Location:415659
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      cd13250
      Location:297393
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:701734
      ANK; ANK repeat [structural motif]
      cd08851
      Location:427541
      ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
      cl12013
      Location:18245
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    6. XM_017006048.2XP_016861537.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X6

    7. XM_017006046.2XP_016861535.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1

    8. XM_047447835.1XP_047303791.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X8

    9. XM_047447837.1XP_047303793.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X8

    10. XM_047447836.1XP_047303792.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X10

    11. XM_047447838.1XP_047303794.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X11

      Related
      ENSP00000412338.2, ENST00000450200.2
    12. XM_047447834.1XP_047303790.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      197972626..198140907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345914.1XP_054201889.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X5

    2. XM_054345918.1XP_054201893.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X9

    3. XM_054345913.1XP_054201888.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X4

    4. XM_054345916.1XP_054201891.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X7

    5. XM_054345912.1XP_054201887.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X3

    6. XM_054345915.1XP_054201890.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X6

    7. XM_054345910.1XP_054201885.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1

    8. XM_054345917.1XP_054201892.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X8

    9. XM_054345920.1XP_054201895.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X8

    10. XM_054345919.1XP_054201894.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X10

    11. XM_054345921.1XP_054201896.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X11

    12. XM_054345911.1XP_054201886.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X2