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    MEDAG mesenteric estrogen dependent adipogenesis [ Homo sapiens (human) ]

    Gene ID: 84935, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MEDAGprovided by HGNC
    Official Full Name
    mesenteric estrogen dependent adipogenesisprovided by HGNC
    Primary source
    HGNC:HGNC:25926
    See related
    Ensembl:ENSG00000102802 AllianceGenome:HGNC:25926
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AWMS3; MEDA4; MEDA-4; hAWMS3; C13orf33
    Summary
    Predicted to be involved in positive regulation of fat cell differentiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in urinary bladder (RPKM 9.4), appendix (RPKM 6.9) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MEDAG in Genome Data Viewer
    Location:
    13q12.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (30906271..30925572)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (30128196..30147488)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (31480408..31499709)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:31379396-31379896 Neighboring gene long intergenic non-protein coding RNA 398 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:31398576-31399105 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:31401421-31402065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7546 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:31436564-31437514 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:31437515-31438463 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:31445187-31445996 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:31445997-31446806 Neighboring gene NANOG hESC enhancer GRCh37_chr13:31459446-31460017 Neighboring gene long intergenic non-protein coding RNA 545 Neighboring gene TEX26 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:31481009-31481510 Neighboring gene testis expressed 26 Neighboring gene uncharacterized LOC105370145 Neighboring gene NANOG hESC enhancer GRCh37_chr13:31557478-31558053 Neighboring gene long intergenic non-protein coding RNA 1066

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of MEDAG as a Hub Candidate Gene in the Onset and Progression of Type 2 Diabetes Mellitus by Comprehensive Bioinformatics Analysis. Yang J, et al. Biomed Res Int, 2021. PMID 33728329, Free PMC Article
    2. Novel genes of visceral adiposity: identification of mouse and human mesenteric estrogen-dependent adipose (MEDA)-4 gene and its adipogenic function. Zhang H, et al. Endocrinology, 2012 Jun. PMID 22510272
    3. Human gingiva transcriptome during wound healing. Wang Y, et al. J Clin Periodontol, 2017 Apr. PMID 28005267
    4. The DNA sequence and analysis of human chromosome 13. Dunham A, et al. Nature, 2004 Apr 1. PMID 15057823, Free PMC Article
    5. HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis. Fujimoto M, et al. Nat Commun, 2022 Jul 29. PMID 35906200, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of MEDAG as a Hub Candidate Gene in the Onset and Progression of Type 2 Diabetes Mellitus by Comprehensive Bioinformatics Analysis.
      Title: Identification of MEDAG as a Hub Candidate Gene in the Onset and Progression of Type 2 Diabetes Mellitus by Comprehensive Bioinformatics Analysis.
    2. MEDAG expression is significantly upregulated in human masticatory mucosa during wound healing
      Title: Human gingiva transcriptome during wound healing.
    3. study identifies Meda-4 as a novel adipogenic gene, capable of promoting differentiation of preadipocytes into adipocytes, increasing lipid content and glucose uptake in adipocytes; it might play an important role in adipose tissue expansion in normal and aberrant hormonal conditions and pathophysiological states
      Title: Novel genes of visceral adiposity: identification of mouse and human mesenteric estrogen-dependent adipose (MEDA)-4 gene and its adipogenic function.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ14834, MGC126673, MGC126675

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mesenteric estrogen-dependent adipogenesis protein
    Names
    activated in W/Wv mouse stomach 3 homolog
    mesenteric estrogen-dependent adipose 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032849.4 → NP_116238.3  mesenteric estrogen-dependent adipogenesis protein

      Status: VALIDATED

      Source sequence(s)
      AL353680
      Consensus CDS
      CCDS9338.1
      UniProtKB/Swiss-Prot
      Q5VYS4, Q8IXF1, Q96K26, Q96NC8
      Related
      ENSP00000369849.4, ENST00000380482.9

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      30906271..30925572
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020801.2 → XP_016876290.1  mesenteric estrogen-dependent adipogenesis protein isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      30128196..30147488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375073.1 → XP_054231048.1  mesenteric estrogen-dependent adipogenesis protein isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5VYS4.1 GenPept UniProtKB/Swiss-Prot:Q5VYS4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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