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    TCP10L t-complex 10 like [ Homo sapiens (human) ]

    Gene ID: 140290, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TCP10Lprovided by HGNC
    Official Full Name
    t-complex 10 likeprovided by HGNC
    Primary source
    HGNC:HGNC:11657
    See related
    Ensembl:ENSG00000242220 MIM:608365; AllianceGenome:HGNC:11657
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRED77; C21orf77; TCP10A-1; TCP10A-2; LINC00846
    Summary
    Enables DNA-binding transcription factor binding activity; identical protein binding activity; and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis (RPKM 24.4) See more
    Orthologs
    all
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    Genomic context

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    See TCP10L in Genome Data Viewer
    Location:
    21q22.11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (32573721..32585523, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (30923998..30951524, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (33946031..33957833, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene eva-1 homolog C Neighboring gene ReSE screen-validated silencer GRCh37_chr21:33870192-33870360 Neighboring gene exosome component 3 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:33891510-33891675 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33905149-33905650 Neighboring gene CFAP298-TCP10L readthrough Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:33933639-33934430 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:33934431-33935222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33941277-33941820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33941821-33942362 Neighboring gene RNA, 5S ribosomal pseudogene 490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33956090-33956590 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:33957672-33957871 Neighboring gene Sharpr-MPRA regulatory region 410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18365 Neighboring gene cilia and flagella associated protein 298 Neighboring gene olfactory receptor family 7 subfamily E member 23 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TCP10L negatively regulates alpha-fetoprotein expression in hepatocellular carcinoma. Shen S, et al. BMB Rep, 2020 Aug. PMID 32438969, Free PMC Article
    2. TCP10L acts as a tumor suppressor by inhibiting cell proliferation in hepatocellular carcinoma. Zuo J, et al. Biochem Biophys Res Commun, 2014 Mar 28. PMID 24565846
    3. Identification of TCP10L as primate-specific gene derived via segmental duplication and homodimerization of TCP10L through the leucine zipper motif. Zhong Z, et al. Mol Biol Rep, 2008 Jun. PMID 17377852
    4. Inactivating Frameshift Mutations of HACD4 and TCP10L Tumor Suppressor Genes in Colorectal and Gastric Cancers. Jo YS, et al. Pathol Oncol Res, 2020 Jan. PMID 29532408
    5. Identification of a novel liver-specific expressed gene, TCP10L, encoding a human leucine zipper protein with transcription inhibition activity. Chen Z, et al. J Hum Genet, 2003. PMID 14586771

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TCP10L negatively regulates alpha-fetoprotein expression in hepatocellular carcinoma.
      Title: TCP10L negatively regulates alpha-fetoprotein expression in hepatocellular carcinoma.
    2. Inactivating Frameshift Mutations of HACD4 and TCP10L Tumor Suppressor Genes in Colorectal and Gastric Cancers.
      Title: Inactivating Frameshift Mutations of HACD4 and TCP10L Tumor Suppressor Genes in Colorectal and Gastric Cancers.
    3. TCP10L stabilizes MAD1 protein level through direct interaction, and they cooperatively regulate cell cycle progression.
      Title: TCP10L synergizes with MAD1 in transcriptional suppression and cell cycle arrest through mutual interaction.
    4. Overexpression of TCP10L in hepatocellular carcinoma cells suppressed colony formation, inhibited cell cycle progression through G0/G1 phase, and attenuated cell growth in vivo.
      Title: TCP10L acts as a tumor suppressor by inhibiting cell proliferation in hepatocellular carcinoma.
    5. The result revealed that TCP10L expressed specifically in the human liver and testis
      Title: Identification of a novel liver-specific expressed gene, TCP10L, encoding a human leucine zipper protein with transcription inhibition activity.
    6. The specific expression pattern of TCP10L and interaction with DAPK-3 implies that TCP10L might play crucially important roles in spermatogenesis through its interaction with DAPK-3.
      Title: TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3.
    7. Data suggest that the biological function of the interaction between T-complex protein 10-like and MAD4 may be to maintain the differentiation state in liver cells.
      Title: Human liver specific transcriptional factor TCP10L binds to MAD4.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough CFAP298-TCP10L

    Readthrough gene: CFAP298-TCP10L, Included gene: CFAP298

    Homology

    Clone Names

    • FLJ10932, MGC34297

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    T-complex protein 10A homolog 1
    Names
    T-complex protein 10A homolog 2
    T-complex protein 10A-1
    T-complex protein 10A-2
    TCP10-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144659.7 → NP_653260.1  T-complex protein 10A homolog 1

      See identical proteins and their annotated locations for NP_653260.1

      Status: VALIDATED

      Source sequence(s)
      AF115967, AP000274, BC027970, BG721020, HY036551
      Consensus CDS
      CCDS13616.1
      UniProtKB/Swiss-Prot
      Q53EW0, Q8TDR4, Q96LN5
      UniProtKB/TrEMBL
      J3KTL9
      Related
      ENSP00000300258.3, ENST00000300258.8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      32573721..32585523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      30923998..30951524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_018277.1: Suppressed sequence

      Description
      NM_018277.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TDR4.1 GenPept UniProtKB/Swiss-Prot:Q8TDR4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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