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    REXO2 RNA exonuclease 2 [ Homo sapiens (human) ]

    Gene ID: 25996, updated on 28-Oct-2024

    Summary

    Official Symbol
    REXO2provided by HGNC
    Official Full Name
    RNA exonuclease 2provided by HGNC
    Primary source
    HGNC:HGNC:17851
    See related
    Ensembl:ENSG00000076043 MIM:607149; AllianceGenome:HGNC:17851
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RFN; SFN; REX2; CGI-114
    Summary
    This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]
    Expression
    Ubiquitous expression in heart (RPKM 41.6), kidney (RPKM 38.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See REXO2 in Genome Data Viewer
    Location:
    11q23.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (114439467..114450279)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (114449884..114460696)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (114310189..114321001)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr11:114270475-114271017 and GRCh37_chr11:114271018-114271560 Neighboring gene chromosome 11 open reading frame 71 Neighboring gene RNA binding motif protein 7 Neighboring gene nocturnin pseudogene Neighboring gene MPRA-validated peak1476 silencer Neighboring gene neurexophilin and PC-esterase domain family member 2 Neighboring gene neurexophilin and PC-esterase domain family member 2 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: RBM7

    Clone Names

    • MGC111570, DKFZp566E144

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 3'-5' exonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables 3'-5'-DNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3'-5'-RNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 3'-5'-RNA exonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
     
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    oligoribonuclease, mitochondrial
    Names
    REX2, RNA exonuclease 2 homolog
    RNA exonuclease 2 homolog
    small fragment nuclease

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015523.4NP_056338.2  oligoribonuclease, mitochondrial precursor

      See identical proteins and their annotated locations for NP_056338.2

      Status: REVIEWED

      Source sequence(s)
      AI249345, BC143701
      Consensus CDS
      CCDS8371.1
      UniProtKB/Swiss-Prot
      B2R532, Q32Q18, Q53FT1, Q6FIC6, Q9UFY7, Q9Y3B8
      UniProtKB/TrEMBL
      F5GYG5
      Related
      ENSP00000265881.5, ENST00000265881.10
      Conserved Domains (1) summary
      cd06135
      Location:43215
      Orn; DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      114439467..114450279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      114449884..114460696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)