U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    LCE2A late cornified envelope 2A [ Homo sapiens (human) ]

    Gene ID: 353139, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    LCE2Aprovided by HGNC
    Official Full Name
    late cornified envelope 2Aprovided by HGNC
    Primary source
    HGNC:HGNC:29469
    See related
    Ensembl:ENSG00000187173 MIM:612609; AllianceGenome:HGNC:29469
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LEP9
    Summary
    Predicted to be involved in keratinization. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward skin (RPKM 30.4) See more
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See LCE2A in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (152698345..152699442)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (151834889..151835986)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152670821..152671918)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene late cornified envelope 2C Neighboring gene late cornified envelope 2B Neighboring gene late cornified envelope 4A Neighboring gene KPRP N-terminal and LCE C-terminal like protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation. Jackson B, et al. J Invest Dermatol, 2005 May. PMID 15854049
    2. Differentially expressed late constituents of the epidermal cornified envelope. Marshall D, et al. Proc Natl Acad Sci U S A, 2001 Nov 6. PMID 11698679, Free PMC Article
    3. Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7. Baxter JS, et al. Mol Oncol, 2024 Feb. PMID 37866880, Free PMC Article
    4. Creation of genome-wide protein expression libraries using random activation of gene expression. Harrington JJ, et al. Nat Biotechnol, 2001 May. PMID 11329013
    5. Assessment of community efforts to advance network-based prediction of protein-protein interactions. Wang XW, et al. Nat Commun, 2023 Mar 22. PMID 36949045, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. paper describing nomenclature changes and expression in range of tissues and in response to UV
      Title: Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See Variation Viewer (GRCh37.p13)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in keratinization IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    late cornified envelope protein 2A
    Names
    late envelope protein 9

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178428.4 → NP_848515.1  late cornified envelope protein 2A

      Status: VALIDATED

      Source sequence(s)
      AL139247, BC119707, BG217525
      Consensus CDS
      CCDS1021.1
      UniProtKB/Swiss-Prot
      A4QMZ9, Q5TA79
      Related
      ENSP00000357768.1, ENST00000368779.2
      Conserved Domains (1) summary
      pfam14672
      Location:71 → 105
      LCE; Late cornified envelope

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      152698345..152699442
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      151834889..151835986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5TA79.1 GenPept UniProtKB/Swiss-Prot:Q5TA79

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous