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    Ark2n arkadia (RNF111) N-terminal like PKA signaling regulator 2N [ Mus musculus (house mouse) ]

    Gene ID: 212163, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ark2nprovided by MGI
    Official Full Name
    arkadia (RNF111) N-terminal like PKA signaling regulator 2Nprovided by MGI
    Primary source
    MGI:MGI:2444951
    See related
    Ensembl:ENSMUSG00000047466 AllianceGenome:MGI:2444951
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Akd2; 8030462N17Rik
    Summary
    Predicted to enable transcription corepressor activity and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of viral life cycle and ubiquitin-dependent protein catabolic process. Predicted to be located in chromatin. Orthologous to human ARK2N (arkadia (RNF111) N-terminal like PKA signaling regulator 2N). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 5.2), frontal lobe adult (RPKM 3.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ark2n in Genome Data Viewer
    Location:
    18 E3; 18 52.38 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (77719184..77802190, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (77631488..77714490, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2C Neighboring gene STARR-seq mESC enhancer starr_45121 Neighboring gene predicted gene, 41784 Neighboring gene predicted gene, 26014 Neighboring gene RIKEN cDNA 4930465K10 gene Neighboring gene RIKEN cDNA A330094K24 gene Neighboring gene RIKEN cDNA 5730552O08 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Affinity Purification-Mass Spectrometry and Single Fiber Physiology/Proteomics Reveals Mechanistic Insights of C18ORF25. Ng YK, et al. J Proteome Res, 2024 Apr 5. PMID 38480473
    2. Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function. Blazev R, et al. Cell Metab, 2022 Oct 4. PMID 35882232
    3. Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. Kelly CE, et al. PLoS Biol, 2013. PMID 23610558, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Affinity Purification-Mass Spectrometry and Single Fiber Physiology/Proteomics Reveals Mechanistic Insights of C18ORF25.
      Title: Affinity Purification-Mass Spectrometry and Single Fiber Physiology/Proteomics Reveals Mechanistic Insights of C18ORF25.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of viral life cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein ARK2N
    Names
    arkadia 2
    protein C18orf25 homolog
    uncharacterized protein C18orf25 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368759.1 → NP_001355688.1  protein ARK2N isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102195, AC162291
      Conserved Domains (1) summary
      pfam15303
      Location:67 → 213
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus

    2. NM_178670.4 → NP_848785.2  protein ARK2N isoform 1

      See identical proteins and their annotated locations for NP_848785.2

      Status: VALIDATED

      Source sequence(s)
      AC102195, AC162291
      Consensus CDS
      CCDS29355.1
      UniProtKB/TrEMBL
      Q0VAW6
      Related
      ENSMUSP00000074225.5, ENSMUST00000074653.6
      Conserved Domains (1) summary
      pfam15303
      Location:67 → 213
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      77719184..77802190 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526426.2 → XP_006526489.1  protein ARK2N isoform X1

      See identical proteins and their annotated locations for XP_006526489.1

      UniProtKB/TrEMBL
      Q0VAW6
      Related
      ENSMUSP00000158108.2, ENSMUST00000237203.2
      Conserved Domains (1) summary
      pfam15303
      Location:67 → 213
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus

    2. XM_011247069.4 → XP_011245371.1  protein ARK2N isoform X3

      See identical proteins and their annotated locations for XP_011245371.1

      Conserved Domains (1) summary
      pfam15303
      Location:67 → 213
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus

    3. XM_006526428.3 → XP_006526491.1  protein ARK2N isoform X5

    4. XM_011247067.4 → XP_011245369.1  protein ARK2N isoform X2

      See identical proteins and their annotated locations for XP_011245369.1

      Conserved Domains (1) summary
      pfam15303
      Location:67 → 213
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus

    5. XM_011247070.4 → XP_011245372.1  protein ARK2N isoform X4

      Conserved Domains (1) summary
      pfam15303
      Location:67 → 213
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001039480.1: Suppressed sequence

      Description
      NM_001039480.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BH50.1 GenPept UniProtKB/Swiss-Prot:Q8BH50

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