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    ZNF282 zinc finger protein 282 [ Homo sapiens (human) ]

    Gene ID: 8427, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF282provided by HGNC
    Official Full Name
    zinc finger protein 282provided by HGNC
    Primary source
    HGNC:HGNC:13076
    See related
    Ensembl:ENSG00000170265 MIM:603397; AllianceGenome:HGNC:13076
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HUB1
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in endometrium (RPKM 6.2), prostate (RPKM 5.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF282 in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (149195546..149226243)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (150377373..150408083)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (148892638..148923334)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger protein 398 Neighboring gene uncharacterized LOC107986856 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:148842175-148842748 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148842749-148843322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148843323-148843896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26809 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:148844471-148845044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18749 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18750 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148853225-148853792 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148853793-148854358 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148854359-148854926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26810 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26811 Neighboring gene centrosomal protein 83kDa pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr7:148892414-148892735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26812 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:148900065-148900565 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:148906433-148907147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:148916930-148917919 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:148923698-148923905 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:148930294-148931493 Neighboring gene Sharpr-MPRA regulatory region 80 Neighboring gene zinc finger protein 212 Neighboring gene uncharacterized LOC124901769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18753 Neighboring gene zinc finger protein 783

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. HUB1, a novel Krüppel type zinc finger protein, represses the human T cell leukemia virus type I long terminal repeat-mediated expression. Okumura K, et al. Nucleic Acids Res, 1997 Dec 15. PMID 9396811, Free PMC Article
    2. SUMOylation of ZFP282 potentiates its positive effect on estrogen signaling in breast tumorigenesis. Yu EJ, et al. Oncogene, 2013 Aug 29. PMID 22986521, Free PMC Article
    3. ZNF282 (Zinc finger protein 282), a novel E2F1 co-activator, promotes esophageal squamous cell carcinoma. Yeo SY, et al. Oncotarget, 2014 Dec 15. PMID 25373738, Free PMC Article
    4. The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification. Helleboid PY, et al. EMBO J, 2019 Sep 16. PMID 31403225, Free PMC Article
    5. A GO catalogue of human DNA-binding transcription factors. Lovering RC, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Nov-Dec. PMID 34673265

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF282 is E2F1 co-activator involved in esophageal squamous cell carcinoma
      Title: ZNF282 (Zinc finger protein 282), a novel E2F1 co-activator, promotes esophageal squamous cell carcinoma.
    2. SUMOylation of ZFP282 potentiates its positive effect on estrogen signaling in breast tumorigenesis.
      Title: SUMOylation of ZFP282 potentiates its positive effect on estrogen signaling in breast tumorigenesis.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 282
    Names
    HTLV-I U5 repressive element-binding protein 1
    HTLV-I U5RE-binding protein 1
    HUB-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303481.3 → NP_001290410.1  zinc finger protein 282 isoform 2

      See identical proteins and their annotated locations for NP_001290410.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate segment in the 3' end compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC004890, AK316282, BC041704, BC073805, D30612
      Consensus CDS
      CCDS78284.1
      UniProtKB/Swiss-Prot
      Q9UDV7
      UniProtKB/TrEMBL
      Q86YG2
      Related
      ENSP00000418840.1, ENST00000479907.1
      Conserved Domains (1) summary
      smart00349
      Location:198 → 260
      KRAB; krueppel associated box

    2. NM_003575.4 → NP_003566.1  zinc finger protein 282 isoform 1

      See identical proteins and their annotated locations for NP_003566.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC041704, BC073805, D30612
      Consensus CDS
      CCDS5895.1
      UniProtKB/Swiss-Prot
      B4DRI5, O43691, Q6DKK0, Q9UDV7
      UniProtKB/TrEMBL
      A0A090N8Y3
      Related
      ENSP00000477841.1, ENST00000610704.5
      Conserved Domains (6) summary
      cd07765
      Location:198 → 237
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:198 → 260
      KRAB; krueppel associated box
      COG5048
      Location:506 → 651
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:548 → 568
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:574 → 596
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:616 → 641
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      149195546..149226243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006716151.5 → XP_006716214.1  zinc finger protein 282 isoform X1

      Conserved Domains (6) summary
      cd07765
      Location:198 → 237
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:198 → 260
      KRAB; krueppel associated box
      COG5048
      Location:507 → 652
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:549 → 569
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:575 → 597
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:617 → 642
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      150377373..150408083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359217.1 → XP_054215192.1  zinc finger protein 282 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UDV7.3 GenPept UniProtKB/Swiss-Prot:Q9UDV7

    Gene LinkOut

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