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    CAMK4 calcium/calmodulin dependent protein kinase IV [ Homo sapiens (human) ]

    Gene ID: 814, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CAMK4provided by HGNC
    Official Full Name
    calcium/calmodulin dependent protein kinase IVprovided by HGNC
    Primary source
    HGNC:HGNC:1464
    See related
    Ensembl:ENSG00000152495 MIM:114080; AllianceGenome:HGNC:1464
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    caMK; CaMKIV; CaMK IV; CaMK-GR
    Summary
    The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in brain (RPKM 7.0), lymph node (RPKM 3.7) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CAMK4 in Genome Data Viewer
    Location:
    5q22.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (111223583..111494886)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (111734219..112005186)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (110559281..110830584)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene proline rich nuclear receptor coactivator 2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16229 Neighboring gene RPS3A pseudogene 21 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16230 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16231 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22896 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:110644539-110645132 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:110783389-110783979 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:110838395-110838556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22899 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16233 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22900 Neighboring gene uncharacterized LOC105369177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22901 Neighboring gene STARD4 antisense RNA 1 Neighboring gene StAR related lipid transfer domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Comparative transcriptome analysis reveals a potential role for CaMK4 in γδT17 cells from systemic lupus erythematosus patients with lupus nephritis. Du B, et al. Int Immunopharmacol, 2020 Mar. PMID 31978801
    2. Effect of pH on the structure, function, and stability of human calcium/calmodulin-dependent protein kinase IV: combined spectroscopic and MD simulation studies. Naz H, et al. Biochem Cell Biol, 2016 Jun. PMID 27032767
    3. Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller. Racioppi L, et al. Trends Immunol, 2008 Dec. PMID 18930438
    4. Lack of association between rs10491334 in the CAMK4 gene and longevity in a Chinese population. Lin R, et al. J Genet, 2016 Sep. PMID 27659345
    5. Regulation of microtubule dynamics by Ca2+/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18. Melander Gradin H, et al. Mol Cell Biol, 1997 Jun. PMID 9154845, Free PMC Article

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses.
      Title: CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses.
    2. CaMK4 overexpression in polycystic kidney disease promotes mTOR-mediated cell proliferation.
      Title: CaMK4 overexpression in polycystic kidney disease promotes mTOR-mediated cell proliferation.
    3. Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis.
      Title: Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis.
    4. CaMK4 promotes abortion-related Th17 cell imbalance by activating AKT/mTOR signaling pathway.
      Title: CaMK4 promotes abortion-related Th17 cell imbalance by activating AKT/mTOR signaling pathway.
    5. CAMKK2-CAMK4 signaling regulates transferrin trafficking, turnover, and iron homeostasis.
      Title: CAMKK2-CAMK4 signaling regulates transferrin trafficking, turnover, and iron homeostasis.
    6. MiR-507 inhibits the growth and invasion of trophoblasts by targeting CAMK4.
      Title: MiR-507 inhibits the growth and invasion of trophoblasts by targeting CAMK4.
    7. Comparative transcriptome analysis reveals a potential role for CaMK4 in gammadeltaT17 cells from systemic lupus erythematosus patients with lupus nephritis.
      Title: Comparative transcriptome analysis reveals a potential role for CaMK4 in γδT17 cells from systemic lupus erythematosus patients with lupus nephritis.
    8. MiR-129-5p inhibits liver cancer growth by targeting calcium calmodulin-dependent protein kinase IV (CAMK4).
      Title: MiR-129-5p inhibits liver cancer growth by targeting calcium calmodulin-dependent protein kinase IV (CAMK4).
    9. rs2300782 of gene CAMK4 is associated with diabetic retinopathy incidence and severity among Chinese Hui population.
      Title: Associations of rs2300782 CAMK4, rs2292239 ERBB3 and rs10491034 ARHGAP22 with Diabetic Retinopathy Among Chinese Hui Population.
    10. CaMK4 could be responsible for glycolysis, which contributes to the production of IL-17, and CaMK4 may contribute to aberrant expression of GLUT1 in T cells from patients with active SLE.
      Title: Promotion of Calcium/Calmodulin-Dependent Protein Kinase 4 by GLUT1-Dependent Glycolysis in Systemic Lupus Erythematosus.
    Submit: New GeneRIF Correction See all GeneRIFs (46)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
    EBI GWAS Catalog
    Association study on long-living individuals from Southern Italy identifies rs10491334 in the CAMKIV gene that regulates survival proteins.
    EBI GWAS Catalog
    Common variation near ROBO2 is associated with expressive vocabulary in infancy.
    EBI GWAS Catalog
    Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness.
    EBI GWAS Catalog
    Genome-wide association study of chronic periodontitis in a general German population.
    EBI GWAS Catalog
    Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-induced neuron death is inhibited by CCL3L1 treatment via the phosphorylation of CREB, the upregulation of Bcl-2, and the PKA and CaMKI/CaMKIV cell signaling pathways PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36771

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-term memory IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in myeloid dendritic cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in positive regulation of myeloid dendritic cell cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of T cell differentiation in thymus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of osteoclast differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calcium/calmodulin-dependent protein kinase type IV
    Names
    CAM kinase IV
    CAM kinase- GR
    brain Ca(2+)-calmodulin-dependent protein kinase type IV
    brain Ca++-calmodulin-dependent protein kinase type IV
    calcium/calmodulin-dependent protein kinase type IV catalytic chain
    NP_001310303.1
    NP_001310304.1
    NP_001310305.1
    NP_001310306.1
    NP_001735.1
    XP_047273739.1
    XP_054209545.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001323374.2 → NP_001310303.1  calcium/calmodulin-dependent protein kinase type IV isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC010468, AC011422, BQ018740, BX374853, L24959
      Consensus CDS
      CCDS4103.1
      UniProtKB/Swiss-Prot
      D3DSZ7, Q16566
      UniProtKB/TrEMBL
      B2R747
      Related
      ENSP00000422634.1, ENST00000512453.5
      Conserved Domains (2) summary
      cd14085
      Location:42 → 335
      STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV
      pfam00069
      Location:46 → 300
      Pkinase; Protein kinase domain

    2. NM_001323375.2 → NP_001310304.1  calcium/calmodulin-dependent protein kinase type IV isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC010275, AC010468, AC011422, BQ018740
      Consensus CDS
      CCDS4103.1
      UniProtKB/Swiss-Prot
      D3DSZ7, Q16566
      UniProtKB/TrEMBL
      B2R747
      Conserved Domains (2) summary
      cd14085
      Location:42 → 335
      STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV
      pfam00069
      Location:46 → 300
      Pkinase; Protein kinase domain

    3. NM_001323376.2 → NP_001310305.1  calcium/calmodulin-dependent protein kinase type IV isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC011422, AK311662, BQ018740, BX374853
      Conserved Domains (1) summary
      cl21453
      Location:1 → 138
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001323377.2 → NP_001310306.1  calcium/calmodulin-dependent protein kinase type IV isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC010275, AC010468, AC011422, BQ018740
      Conserved Domains (1) summary
      cl21453
      Location:1 → 138
      PKc_like; Protein Kinases, catalytic domain

    5. NM_001744.6 → NP_001735.1  calcium/calmodulin-dependent protein kinase type IV isoform 1

      See identical proteins and their annotated locations for NP_001735.1

      Status: REVIEWED

      Source sequence(s)
      AC011422, BC025687, BQ018740, DA396146
      Consensus CDS
      CCDS4103.1
      UniProtKB/Swiss-Prot
      D3DSZ7, Q16566
      UniProtKB/TrEMBL
      B2R747
      Related
      ENSP00000282356.4, ENST00000282356.9
      Conserved Domains (2) summary
      cd14085
      Location:42 → 335
      STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV
      pfam00069
      Location:46 → 300
      Pkinase; Protein kinase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      111223583..111494886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417783.1 → XP_047273739.1  calcium/calmodulin-dependent protein kinase type IV isoform X1

    RNA

    1. XR_948303.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      111734219..112005186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353570.1 → XP_054209545.1  calcium/calmodulin-dependent protein kinase type IV isoform X1

    RNA

    1. XR_008487178.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16566.1 GenPept UniProtKB/Swiss-Prot:Q16566

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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