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    Map3k2 mitogen-activated protein kinase kinase kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 26405, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Map3k2provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase kinase 2provided by MGI
    Primary source
    MGI:MGI:1346873
    See related
    Ensembl:ENSMUSG00000024383 AllianceGenome:MGI:1346873
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mekk2; Mekk2b; 9630061B06Rik
    Summary
    Predicted to enable MAP kinase kinase kinase activity and protein kinase binding activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; integumental system; respiratory system; and sensory organ. Orthologous to human MAP3K2 (mitogen-activated protein kinase kinase kinase 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 3.3), placenta adult (RPKM 2.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Map3k2 in Genome Data Viewer
    Location:
    18 B1; 18 17.95 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (32296142..32369804)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (32163089..32236751)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11799 Neighboring gene eukaryotic translation initiation factor pseudogene Neighboring gene predicted gene, 26717 Neighboring gene predicted gene, 34806 Neighboring gene STARR-seq mESC enhancer starr_44156 Neighboring gene STARR-positive B cell enhancer ABC_E5649 Neighboring gene excision repair cross-complementing rodent repair deficiency, complementation group 3 Neighboring gene STARR-seq mESC enhancer starr_44157 Neighboring gene RIKEN cDNA A830052D11 gene Neighboring gene bridging integrator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Comments on 'MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche'. Wu N, et al. J Mol Cell Biol, 2021 Sep 11. PMID 34010396, Free PMC Article
    2. MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. Wu N, et al. Nature, 2021 Apr. PMID 33658717
    3. Tumor-derived exosomes antagonize innate antiviral immunity. Gao L, et al. Nat Immunol, 2018 Mar. PMID 29358709
    4. MEKK2 is required for T-cell receptor signals in JNK activation and interleukin-2 gene expression. Su B, et al. J Biol Chem, 2001 May 4. PMID 11278622
    5. Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction. Guo Z, et al. Mol Cell Biol, 2002 Aug. PMID 12138187, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2.
      Title: E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2.
    2. MiR-20a-5p facilitates cartilage repair in osteoarthritis via suppressing mitogen-activated protein kinase kinase kinase 2.
      Title: MiR-20a-5p facilitates cartilage repair in osteoarthritis via suppressing mitogen-activated protein kinase kinase kinase 2.
    3. Comments on 'MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche'.
      Title: Comments on 'MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche'.
    4. MAP3K2 augments Th1 cell differentiation via IL-18 to promote T cell-mediated colitis.
      Title: MAP3K2 augments Th1 cell differentiation via IL-18 to promote T cell-mediated colitis.
    5. MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche.
      Title: MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche.
    6. MEKK2 mediates aberrant ERK activation in neurofibromatosis type I.
      Title: MEKK2 mediates aberrant ERK activation in neurofibromatosis type I.
    7. Erk5 MAP kinase is activated in response to PDGF-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2, Mek1/2, Mek5, PI3-kinase and protein kinase C (PKC).
      Title: Platelet-derived growth factor (PDGF)-induced activation of Erk5 MAP-kinase is dependent on Mekk2, Mek1/2, PKC and PI3-kinase, and affects BMP signaling.
    8. FGF2/MEKK2 pathway mediates an alternative nonclassical pathway for beta-catenin activation, and this pathway is a key regulator of bone formation by osteoblasts
      Title: MEKK2 mediates an alternative β-catenin pathway that promotes bone formation.
    9. Stk38 protein kinase has a role in inhibiting TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages
      Title: Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages.
    10. methylation of MAP3K2 by SMYD3 increases MAP kinase signalling and promotes the formation of Ras-driven carcinomas
      Title: SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 2
    Names
    MAP/ERK kinase kinase 2
    MAPK/ERK kinase kinase 2
    MEK kinase 2
    MEKK 2
    protein kinase MEKK2b
    NP_036076.2
    XP_036017049.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011946.3 → NP_036076.2  mitogen-activated protein kinase kinase kinase 2

      See identical proteins and their annotated locations for NP_036076.2

      Status: VALIDATED

      Source sequence(s)
      AC126686
      Consensus CDS
      CCDS29117.1
      UniProtKB/Swiss-Prot
      Q61083
      UniProtKB/TrEMBL
      G5E8L8
      Related
      ENSMUSP00000094326.4, ENSMUST00000096575.5
      Conserved Domains (2) summary
      cd06405
      Location:44 → 122
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06652
      Location:353 → 616
      STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      32296142..32369804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161156.1 → XP_036017049.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q61083
      UniProtKB/TrEMBL
      G5E8L8
      Conserved Domains (2) summary
      cd06405
      Location:44 → 122
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06652
      Location:353 → 616
      STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61083.2 GenPept UniProtKB/Swiss-Prot:Q61083

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