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    Mmrn2 multimerin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306288, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Mmrn2provided by RGD
    Official Full Name
    multimerin 2provided by RGD
    Primary source
    RGD:1311461
    See related
    EnsemblRapid:ENSRNOG00000051977 AllianceGenome:RGD:1311461
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable receptor ligand activity. Predicted to be involved in several processes, including cell migration involved in sprouting angiogenesis; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; and negative regulation of cell migration involved in sprouting angiogenesis. Predicted to be located in basement membrane and extracellular space. Orthologous to human MMRN2 (multimerin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 159.0), Lung (RPKM 138.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mmrn2 in Genome Data Viewer
    Location:
    16p15
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (9712181..9733653)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (9705925..9727405)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (10727552..10749303)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 25, member A Neighboring gene synuclein, gamma Neighboring gene bone morphogenetic protein receptor type 1A Neighboring gene T-enol, pseudogene 1 Neighboring gene uncharacterized LOC108353075

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of EndoGlyx-1, an EMILIN-like multisubunit glycoprotein of vascular endothelium. Christian S, et al. J Biol Chem, 2001 Dec 21. PMID 11559704
    2. Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth. Noy PJ, et al. Oncogene, 2015 Nov 19. PMID 25745997, Free PMC Article
    3. MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway. Lorenzon E, et al. Oncogene, 2012 Jun 28. PMID 22020326
    4. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article
    5. SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Zanivan S, et al. Mol Cell Proteomics, 2013 Dec. PMID 23979707, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration involved in sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epithelial tube formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of morphogenesis of an epithelium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    multimerin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372014.1 → NP_001358943.1  multimerin-2 precursor

      Status: VALIDATED

      Source sequence(s)
      FQ218167, JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6GHU7
      Related
      ENSRNOP00000074627.2, ENSRNOT00000084422.3
      Conserved Domains (4) summary
      TIGR02168
      Location:518 → 777
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:249 → 585
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00386
      Location:811 → 930
      C1q; C1q domain
      pfam07546
      Location:57 → 127
      EMI; EMI domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      9712181..9733653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094475.2 → XP_038950403.1  multimerin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GHU7
      Related
      ENSRNOP00000089998.2, ENSRNOT00000110870.2
      Conserved Domains (3) summary
      pfam15921
      Location:292 → 650
      CCDC158; Coiled-coil domain-containing protein 158
      pfam00386
      Location:854 → 973
      C1q; C1q domain
      pfam07546
      Location:100 → 170
      EMI; EMI domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107298.1: Suppressed sequence

      Description
      NM_001107298.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: MMRN2 (GeneID:79812).
    Nucleotide Protein Strain
    Heading Accession and Version

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