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    pck2 protein kinase C (PKC)-like Pck2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539649, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pck2
    Official Full Name
    protein kinase C (PKC)-like Pck2
    Primary source
    PomBase:SPBC12D12.04c
    Locus tag
    SPOM_SPBC12D12.04C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mok3; pkc1; sts6
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    Genomic context

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    See pck2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (2309126..2313008, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene chaperonin-containing T-complex alpha subunit Cct1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene calcium-binding subfamily carrier protein Neighboring gene DNA polymerase zeta Rev7 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fission yeast protein kinase C gene homologues are required for protoplast regeneration: a functional link between cell wall formation and cell shape control. Kobori H, et al. J Cell Sci, 1994 May. PMID 7929623
    2. Rkp1/Cpc2, a fission yeast RACK1 homolog, is involved in actin cytoskeleton organization through protein kinase C, Pck2, signaling. Won M, et al. Biochem Biophys Res Commun, 2001 Mar 23. PMID 11263963
    3. Two novel protein kinase C-related genes of fission yeast are essential for cell viability and implicated in cell shape control. Toda T, et al. EMBO J, 1993 May. PMID 8491190, Free PMC Article
    4. The fission yeast pmk1+ gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway. Toda T, et al. Mol Cell Biol, 1996 Dec. PMID 8943330, Free PMC Article
    5. Ksg1, a homologue of the phosphoinositide-dependent protein kinase 1, controls cell wall integrity in Schizosaccharomyces pombe. Gräub R, et al. J Basic Microbiol, 2003. PMID 14625898

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Constitutive Pck activation promoted dephosphorylation and destabilization of Pck2, whereas it enhanced Pck1 levels to interfere with proper downstream signaling to the cell integrity pathway via Pck2.
      Title: Differential functional regulation of protein kinase C (PKC) orthologs in fission yeast.
    2. We show that in vivo phosphorylation of Pck2 at the conserved T842 activation loop during growth and in response to different stresses is mediated by the phosphoinositide-dependent kinase (PDK) ortholog Ksg1 and an autophosphorylation mechanism
      Title: Multiple layers of regulation influence cell integrity control by the PKC ortholog Pck2 in fission yeast.
    3. both Rho1 and Pck1 are positive upstream regulatory members of the CIP in addition to Rho2 and Pck2.
      Title: Rho1 GTPase and PKC ortholog Pck1 are upstream activators of the cell integrity MAPK pathway in fission yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol-dependent serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables lipid binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fungal-type cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of glucose mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell integrity MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of cell wall (1->3)-beta-D-glucan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of establishment or maintenance of cell polarity regulating cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of fungal-type cell wall (1->3)-alpha-glucan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell division site HDA PubMed 
    is_active_in cell tip HDA PubMed 
    is_active_in division septum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein kinase C (PKC)-like Pck2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2309126..2313008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021859.3 → NP_595950.1  protein kinase C (PKC)-like Pck2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595950.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P36583, Q9UU42
      Conserved Domains (6) summary
      cd08689
      Location:213 → 320
      C2_fungal_Pkc1p; C2 domain found in protein kinase C (Pkc1p) in Saccharomyces cerevisiae
      cd11620
      Location:115 → 186
      HR1_PKC-like_2_fungi; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of fungal Protein Kinase C-like proteins
      cd11621
      Location:2 → 73
      HR1_PKC-like_1_fungi; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of fungal Protein Kinase C-like proteins
      smart00220
      Location:683 → 942
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05570
      Location:688 → 1003
      STKc_PKC; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C
      pfam00130
      Location:406 → 454
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    Nucleotide Protein
    Heading Accession and Version

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