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    shw-1 BTB domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174331, updated on 2-Nov-2024

    Summary

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    Official Symbol
    shw-1
    Official Full Name
    BTB domain-containing protein
    Primary source
    WormBase:WBGene00008819
    Locus tag
    CELE_F14F11.1
    See related
    AllianceGenome:WB:WBGene00008819
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable delayed rectifier potassium channel activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in several cellular components, including dendrite membrane; neuronal cell body membrane; and synaptic membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 103; progressive myoclonus epilepsy 7; and spinocerebellar ataxia type 13. Orthologous to several human genes including KCNC1 (potassium voltage-gated channel subfamily C member 1); KCNC2 (potassium voltage-gated channel subfamily C member 2); and KCNC4 (potassium voltage-gated channel subfamily C member 4). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See shw-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    23
    Sequence:
    Chromosome: II; NC_003280.10 (8305745..8321471, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Regulator of chromosome condensation Neighboring gene Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 Neighboring gene Spliceosome RNA helicase DDX39B homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An actin-based viscoplastic lock ensures progressive body-axis elongation. Lardennois A, et al. Nature, 2019 Sep. PMID 31462781, Free PMC Article
    2. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables delayed rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendrite membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuronal cell body membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BTB domain-containing protein
    NP_001022089.1
    • Partially confirmed by transcript evidence
    NP_001367032.1
    • Partially confirmed by transcript evidence
    NP_001379089.1
    • Confirmed by transcript evidence
    NP_871938.1
    • Confirmed by transcript evidence
    NP_871939.1
    • Confirmed by transcript evidence
    NP_871940.1
    • Confirmed by transcript evidence
    NP_871941.1
    • Confirmed by transcript evidence
    NP_871942.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8305745..8321471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026918.5 → NP_001022089.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022089.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC00
      Conserved Domains (2) summary
      cd18416
      Location:100 → 211
      BTB_Shaw-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw
      pfam00520
      Location:264 → 521
      Ion_trans; Ion transport protein

    2. NM_001393135.1 → NP_001379089.1  BTB domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19464
      Conserved Domains (2) summary
      cd18416
      Location:4 → 115
      BTB_Shaw-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw
      pfam00520
      Location:223 → 426
      Ion_trans; Ion transport protein

    3. NM_001381523.1 → NP_001367032.1  BTB domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDK3
      Conserved Domains (2) summary
      cd18416
      Location:100 → 211
      BTB_Shaw-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw
      pfam00520
      Location:319 → 522
      Ion_trans; Ion transport protein

    4. NM_182138.5 → NP_871938.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871938.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECD2
      Conserved Domains (2) summary
      cd18416
      Location:54 → 165
      BTB_Shaw-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw
      pfam00520
      Location:283 → 476
      Ion_trans; Ion transport protein

    5. NM_182139.3 → NP_871939.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871939.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I4L4
      Conserved Domains (2) summary
      cd18416
      Location:14 → 125
      BTB_Shaw-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw
      pfam00520
      Location:243 → 436
      Ion_trans; Ion transport protein

    6. NM_182140.3 → NP_871940.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871940.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I4L3
      Conserved Domains (2) summary
      cd18416
      Location:27 → 138
      BTB_Shaw-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw
      pfam00520
      Location:256 → 449
      Ion_trans; Ion transport protein

    7. NM_182141.6 → NP_871941.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871941.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I4L2
      Conserved Domains (2) summary
      cd18416
      Location:21 → 132
      BTB_Shaw-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw
      pfam00520
      Location:250 → 443
      Ion_trans; Ion transport protein

    8. NM_182142.5 → NP_871942.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871942.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I4L1
      Conserved Domains (2) summary
      cd18416
      Location:24 → 135
      BTB_Shaw-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw
      pfam00520
      Location:253 → 446
      Ion_trans; Ion transport protein
    Nucleotide Protein
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