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    sorb-1 SH3 domain-containing protein;Sorbin and SH3 domain-containing protein 1 homolog [ Caenorhabditis elegans ]

    Gene ID: 3565590, updated on 2-Nov-2024

    Summary

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    Official Symbol
    sorb-1
    Official Full Name
    SH3 domain-containing protein;Sorbin and SH3 domain-containing protein 1 homolog
    Primary source
    WormBase:WBGene00012891
    Locus tag
    CELE_Y45F10D.13
    See related
    AllianceGenome:WB:WBGene00012891
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in maintenance of mitochondrion location and sarcomere organization. Located in dense body; focal adhesion; and plasma membrane. Is expressed in body wall musculature; non-striated muscle; and uterus. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to several human genes including SORBS1 (sorbin and SH3 domain containing 1) and SORBS2 (sorbin and SH3 domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See sorb-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    15
    Sequence:
    Chromosome: IV; NC_003282.8 (13750333..13770497)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rhotekin regulates axon regeneration through the talin-Vinculin-Vinexin axis in Caenorhabditis elegans. Sakai Y, et al. PLoS Genet, 2023 Dec. PMID 38150455, Free PMC Article
    2. Caenorhabditis elegans SORB-1 localizes to integrin adhesion sites and is required for organization of sarcomeres and mitochondria in myocytes. Loveless T, et al. Mol Biol Cell, 2017 Dec 1. PMID 28978740, Free PMC Article
    3. RTKN-1/Rhotekin shields endosome-associated F-actin from disassembly to ensure endocytic recycling. Yan Y, et al. J Cell Biol, 2021 May 3. PMID 33844824, Free PMC Article
    4. SKIP and BIR-1/Survivin have potential to integrate proteome status with gene expression. Kostrouch D, et al. J Proteomics, 2014 Oct 14. PMID 25088050
    5. A snapshot of the physical and functional wiring of the Eps15 homology domain network in the nematode. Tsushima H, et al. PLoS One, 2013. PMID 23424658, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maintenance of mitochondrion location IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dense body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SH3 domain-containing protein;Sorbin and SH3 domain-containing protein 1 homolog
    NP_001041035.2
    • Confirmed by transcript evidence
    NP_001255756.1
    • Confirmed by transcript evidence
    NP_001360603.1
    • Confirmed by transcript evidence
    NP_001360609.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13750333..13770497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001372957.3 → NP_001360603.1  SH3 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IL10
      Conserved Domains (3) summary
      cd11780
      Location:952 → 1006
      SH3_Sorbs_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing (Sorbs) proteins and similar domains
      cd11781
      Location:687 → 739
      SH3_Sorbs_1; First Src Homology 3 domain of Sorbin and SH3 domain containing (Sorbs) proteins and similar domains
      cl02617
      Location:505 → 553
      Sorb; Sorbin homologous domain

    2. NM_001047570.4 → NP_001041035.2  Sorbin and SH3 domain-containing protein 1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041035.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EC32, O62482
      Conserved Domains (3) summary
      cd11780
      Location:950 → 1004
      SH3_Sorbs_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing (Sorbs) proteins and similar domains
      cd11781
      Location:687 → 739
      SH3_Sorbs_1; First Src Homology 3 domain of Sorbin and SH3 domain containing (Sorbs) proteins and similar domains
      cl02617
      Location:505 → 553
      Sorb; Sorbin homologous domain

    3. NM_001372958.2 → NP_001360609.1  SH3 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IMT6
      Conserved Domains (2) summary
      cd11780
      Location:420 → 474
      SH3_Sorbs_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing (Sorbs) proteins and similar domains
      cd11781
      Location:155 → 207
      SH3_Sorbs_1; First Src Homology 3 domain of Sorbin and SH3 domain containing (Sorbs) proteins and similar domains

    4. NM_001268827.5 → NP_001255756.1  Sorbin and SH3 domain-containing protein 1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255756.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62482
      Conserved Domains (2) summary
      cd11780
      Location:418 → 472
      SH3_Sorbs_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing (Sorbs) proteins and similar domains
      cd11781
      Location:155 → 207
      SH3_Sorbs_1; First Src Homology 3 domain of Sorbin and SH3 domain containing (Sorbs) proteins and similar domains

    RNA

    1. NR_003162.2 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EC32.1

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