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    ZNF704 zinc finger protein 704 [ Homo sapiens (human) ]

    Gene ID: 619279, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ZNF704provided by HGNC
    Official Full Name
    zinc finger protein 704provided by HGNC
    Primary source
    HGNC:HGNC:32291
    See related
    Ensembl:ENSG00000164684 AllianceGenome:HGNC:32291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Gig1
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in endometrium (RPKM 8.6), ovary (RPKM 8.1) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF704 in Genome Data Viewer
    Location:
    8q21.13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (80628451..80884419, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (81060029..81315991, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (81540686..81787016, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene SLC25A51 pseudogene 3 Neighboring gene RNA, 7SL, cytoplasmic 107, pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:81552571-81553770 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:81610513-81611014 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:81611015-81611514 Neighboring gene RNA, U11 small nuclear 6, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 308, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:81734976-81736175 Neighboring gene high mobility group box 1 pseudogene 41 Neighboring gene MPRA-validated peak7088 silencer Neighboring gene uncharacterized LOC107986894 Neighboring gene HNF4 motif-containing MPRA enhancer 108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27570 Neighboring gene uncharacterized LOC124901967 Neighboring gene phosphoprotein membrane anchor with glycosphingolipid microdomains 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Circadian Rhythm Is Disrupted by ZNF704 in Breast Carcinogenesis. Yang C, et al. Cancer Res, 2020 Oct 1. PMID 32651256
    2. Circular RNA HSDL2 promotes breast cancer progression via miR-7978 ZNF704 axis and regulating hippo signaling pathway. Wang D, et al. Breast Cancer Res, 2024 Jun 27. PMID 38937788, Free PMC Article
    3. A four-gene transcript score to predict metastatic-lethal progression in men treated for localized prostate cancer: Development and validation studies. Cheng A, et al. Prostate, 2019 Oct. PMID 31376183, Free PMC Article
    4. DNA Damage Regulates Translation through β-TRCP Targeting of CReP. Loveless TB, et al. PLoS Genet, 2015 Jun. PMID 26091241, Free PMC Article
    5. Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase. Kim TY, et al. Mol Cell Biol, 2015 Jan. PMID 25332235, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circular RNA HSDL2 promotes breast cancer progression via miR-7978 ZNF704 axis and regulating hippo signaling pathway.
      Title: Circular RNA HSDL2 promotes breast cancer progression via miR-7978 ZNF704 axis and regulating hippo signaling pathway.
    2. Circadian Rhythm Is Disrupted by ZNF704 in Breast Carcinogenesis.
      Title: Circadian Rhythm Is Disrupted by ZNF704 in Breast Carcinogenesis.
    3. tumor marker zinc finger protein 704 as part of a four gene transcript score has prognostic value for metastatic-lethal progression in men treated for localized prostate cancer
      Title: A four-gene transcript score to predict metastatic-lethal progression in men treated for localized prostate cancer: Development and validation studies.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16218, MGC10858

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 704

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033723.3 → NP_001028895.1  zinc finger protein 704 isoform 1

      See identical proteins and their annotated locations for NP_001028895.1

      Status: VALIDATED

      Source sequence(s)
      AC022598, AK131274, BC004287, BM683148, BX112159
      Consensus CDS
      CCDS34913.1
      UniProtKB/Swiss-Prot
      B2RNE6, B9EGW6, Q6ZNC4
      Related
      ENSP00000331462.3, ENST00000327835.7
      Conserved Domains (1) summary
      cl25496
      Location:248 → 374
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    2. NM_001367783.1 → NP_001354712.1  zinc finger protein 704 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022598, AC024367
      Consensus CDS
      CCDS94322.1
      UniProtKB/TrEMBL
      E5RGL7
      Related
      ENSP00000427715.2, ENST00000519936.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      80628451..80884419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013725.2 → XP_016869214.1  zinc finger protein 704 isoform X1

    RNA

    1. XR_928797.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      81060029..81315991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360961.1 → XP_054216936.1  zinc finger protein 704 isoform X1

    RNA

    1. XR_008487869.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_032651.1: Suppressed sequence

      Description
      NM_032651.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZNC4.1 GenPept UniProtKB/Swiss-Prot:Q6ZNC4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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