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    ser-2 G-protein coupled receptors family 1 profile domain-containing protein;Tyramine receptor Ser-2 [ Caenorhabditis elegans ]

    Gene ID: 182110, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ser-2
    Official Full Name
    G-protein coupled receptors family 1 profile domain-containing protein;Tyramine receptor Ser-2
    Primary source
    WormBase:WBGene00004777
    Locus tag
    CELE_C02D4.2
    See related
    AllianceGenome:WB:WBGene00004777
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables tyramine receptor activity. Involved in octopamine or tyramine signaling pathway. Located in plasma membrane. Is expressed in body wall musculature; excretory gland cell; neurons; non-striated muscle; and uterine toroidal epithelial cell. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ser-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    14
    Sequence:
    Chromosome: X; NC_003284.9 (15286533..15302963, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Ile Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tyramine receptor (SER-2) isoforms are involved in the regulation of pharyngeal pumping and foraging behavior in Caenorhabditis elegans. Rex E, et al. J Neurochem, 2004 Dec. PMID 15569254
    2. Characterization of a tyramine receptor from Caenorhabditis elegans. Rex E, et al. J Neurochem, 2002 Sep. PMID 12354282
    3. Role of tyramine in calcium dynamics of GABAergic neurons and escape behavior in Caenorhabditis elegans. Kagawa-Nagamura Y, et al. Zoological Lett, 2018. PMID 30065850, Free PMC Article
    4. Distinct Circuits for the Formation and Retrieval of an Imprinted Olfactory Memory. Jin X, et al. Cell, 2016 Feb 11. PMID 26871629, Free PMC Article
    5. Nematicidal activity of two monoterpenoids and SER-2 tyramine receptor of Caenorhabditis elegans. Lei J, et al. Biochem Pharmacol, 2010 Apr 1. PMID 19896925

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tyramine receptor (SER-2) isoforms are involved in the regulation of pharyngeal pumping and foraging behavior in Caenorhabditis elegans.
      Title: Tyramine receptor (SER-2) isoforms are involved in the regulation of pharyngeal pumping and foraging behavior in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled amine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables octopamine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tyramine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled dopamine receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in octopamine or tyramine signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptors family 1 profile domain-containing protein;Tyramine receptor Ser-2
    NP_001024335.1
    • Confirmed by transcript evidence
    NP_001024336.1
    • Confirmed by transcript evidence
    NP_001024337.1
    • Partially confirmed by transcript evidence
    NP_001024338.1
    • Partially confirmed by transcript evidence
    NP_001024339.1
    • Confirmed by transcript evidence
    NP_001024340.1
    • Confirmed by transcript evidence
    NP_001257260.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15286533..15302963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029165.5 → NP_001024336.1  Tyramine receptor Ser-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024336.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3IUK5
      Conserved Domains (1) summary
      pfam00001
      Location:71 → 397
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. NM_001029164.3 → NP_001024335.1  Tyramine receptor Ser-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024335.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3IUK5
      Conserved Domains (1) summary
      pfam00001
      Location:74 → 400
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    3. NM_001270331.4 → NP_001257260.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257260.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3IUK5, H2FLI4
      Conserved Domains (1) summary
      cd15060
      Location:58 → 399
      7tmA_tyramine_octopamine_R-like; tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. NM_001029168.4 → NP_001024339.1  Tyramine receptor Ser-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024339.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02213, Q6LA87, Q6LA88, Q6LA89, Q6LA90
      UniProtKB/TrEMBL
      D3IUK5
      Conserved Domains (1) summary
      pfam00001
      Location:74 → 423
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    5. NM_001029169.5 → NP_001024340.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024340.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3IUK5, G5EF04
      Conserved Domains (1) summary
      cd15060
      Location:47 → 400
      7tmA_tyramine_octopamine_R-like; tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors

    6. NM_001029167.1 → NP_001024338.1  Tyramine receptor Ser-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024338.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02213
      Conserved Domains (1) summary
      pfam00001
      Location:68 → 173
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    7. NM_001029166.1 → NP_001024337.1  Tyramine receptor Ser-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024337.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02213
      Conserved Domains (1) summary
      pfam00001
      Location:71 → 176
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02213.4

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