PRNP prion protein (Kanno blood group) [Ovis aries (sheep)] - Gene

Summary

Gene symbol: PRNP
Gene description: prion protein (Kanno blood group)
See related: EnsemblRapid:ENSOARG00020038714
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Ovis aries
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Also known as: Prp; SIP; PRPC; prion; AltPrP
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	ARS-UI_Ramb_v3.0 (GCF_016772045.2)	13	NC_056066.1 (46638372..46658965)

Chromosome 13 - NC_056066.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_056066.1 Chromosome 13 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Canine D163-PrP polymorphic variant does not provide complete protection against prion infection in small ruminant PrP context.
Title: Canine D(163)-PrP polymorphic variant does not provide complete protection against prion infection in small ruminant PrP context.
BSE can propagate in sheep co-infected or pre-infected with scrapie.
Title: BSE can propagate in sheep co-infected or pre-infected with scrapie.
the off-pathway PrP oligomers interact with lipid membrane via a distinct mechanism, compared to the inserted lipid-induced intermediates.
Title: Membrane interaction of off-pathway prion oligomers and lipid-induced on-pathway intermediates during prion conversion: A clue for neurotoxicity.
To determine the relative amounts of PrP polymorphisms present in atypical scrapie, total PrP was digested with chymotrypsin to generate characteristic peptides spanning relevant polymorphisms at positions 136, 141, 154, 171, and 172 of sheep PrP(C). An atypical scrapie infection does not result from an overexpression of sheep PrP(C).
Title: Determining the Relative Susceptibility of Four Prion Protein Genotypes to Atypical Scrapie.
Data suggest that prion protein (PrP) oligomers constitute a highly dynamic population.
Title: The mechanism of monomer transfer between two structurally distinct PrP oligomers.
There were no associations of any PRNP genotype with any leukocyte count
Title: Ovine leukocyte profiles do not associate with variation in the prion gene, but are breed dependent.
This study examined 7 deviant ovine field cases of scrapie for some typical molecular aspects of PrP(res) found in CH1641scrapie, classical scrapie and bovine spongiform encephalopathy.
Title: Sheep prions with molecular properties intermediate between classical scrapie, BSE and CH1641-scrapie.
our observations show amino acid residues 141 and 154 influence secondary structure and conformational change in ovine PrP that may correlate with different forms of scrapie
Title: Polymorphisms at amino acid residues 141 and 154 influence conformational variation in ovine PrP.
The predominant Q allele occurred at codon 171 of prion with a 88.68 %frequency.
Title: Allelic variants of PRNP in 16 Chinese local sheep breeds.
the tight correlation between small size, conversion efficiency and duration of disease establishes PrP(Sc) quaternary structure as a determining factor of prion replication dynamics.
Title: Quaternary structure of pathological prion protein as a determining factor of strain-specific prion replication dynamics.

Submit: New GeneRIF Correction See all GeneRIFs (56)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: major prion protein

Names: alternative prion protein; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.