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    Rpl3l ribosomal protein L3-like [ Mus musculus (house mouse) ]

    Gene ID: 66211, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rpl3lprovided by MGI
    Official Full Name
    ribosomal protein L3-likeprovided by MGI
    Primary source
    MGI:MGI:1913461
    See related
    Ensembl:ENSMUSG00000002500 AllianceGenome:MGI:1913461
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110057H16Rik
    Summary
    A structural constituent of ribosome. Involved in negative regulation of myotube differentiation and regulation of striated muscle tissue development. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2D. Orthologous to human RPL3L (ribosomal protein L3 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in heart adult (RPKM 33.5), mammary gland adult (RPKM 7.6) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Rpl3l in Genome Data Viewer
    Location:
    17 A3.3; 17 12.52 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24946800..24955117)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24727826..24736143)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 64 Neighboring gene ribosomal protein S2 Neighboring gene STARR-positive B cell enhancer ABC_E1936 Neighboring gene NADH:ubiquinone oxidoreductase subunit B10 Neighboring gene STARR-positive B cell enhancer ABC_E265 Neighboring gene methionine sulfoxide reductase B1 Neighboring gene heparan sulfate (glucosamine) 3-O-sulfotransferase 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function. Shiraishi C, et al. Nat Commun, 2023 Apr 20. PMID 37080962, Free PMC Article
    2. Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart. Milenkovic I, et al. Nucleic Acids Res, 2023 Jun 23. PMID 36882085, Free PMC Article
    3. Rpl3l gene deletion in mice reduces heart weight over time. Grimes KM, et al. Front Physiol, 2023. PMID 36733907, Free PMC Article
    4. Knockdown of Muscle-Specific Ribosomal Protein L3-Like Enhances Muscle Function in Healthy and Dystrophic Mice. Kao BR, et al. Nucleic Acid Ther, 2021 Dec. PMID 34081545
    5. Expression of Muscle-Specific Ribosomal Protein L3-Like Impairs Myotube Growth. Chaillou T, et al. J Cell Physiol, 2016 Sep. PMID 26684695, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exploring the Regulation and Function of Rpl3l in the Development of Early-Onset Dilated Cardiomyopathy and Congestive Heart Failure Using Systems Genetics Approach.
      Title: Exploring the Regulation and Function of Rpl3l in the Development of Early-Onset Dilated Cardiomyopathy and Congestive Heart Failure Using Systems Genetics Approach.
    2. Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart.
      Title: Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart.
    3. RPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function.
      Title: RPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function.
    4. Knockdown of Muscle-Specific Ribosomal Protein L3-Like Enhances Muscle Function in Healthy and Dystrophic Mice.
      Title: Knockdown of Muscle-Specific Ribosomal Protein L3-Like Enhances Muscle Function in Healthy and Dystrophic Mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of myotube differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of striated muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL3-like
    Names
    60S ribosomal protein L3-like
    ribosomal protein L3 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163945.2 → NP_001157417.1  large ribosomal subunit protein uL3-like isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AC154566
      Consensus CDS
      CCDS50019.1
      UniProtKB/Swiss-Prot
      E9PWZ3, Q5U470, Q9CQ09
      Related
      ENSMUSP00000129325.2, ENSMUST00000170239.9
      Conserved Domains (2) summary
      PTZ00103
      Location:1 → 400
      PTZ00103; 60S ribosomal protein L3; Provisional
      cl00324
      Location:7 → 373
      RplC; Ribosomal protein L3 [Translation, ribosomal structure and biogenesis]

    2. NM_025425.5 → NP_079701.1  large ribosomal subunit protein uL3-like isoform 2

      See identical proteins and their annotated locations for NP_079701.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different segment for its 5' UTR, lacks some 5' coding region segments, and uses a downstream AUG codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AC154566
      Consensus CDS
      CCDS37494.1
      UniProtKB/TrEMBL
      Q9CQ09
      Related
      ENSMUSP00000038326.9, ENSMUST00000045186.11
      Conserved Domains (1) summary
      cl00324
      Location:9 → 206
      RplC; Ribosomal protein L3 [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24946800..24955117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249982.2 → XP_030105842.1  large ribosomal subunit protein uL3-like isoform X1

      Conserved Domains (1) summary
      PTZ00103
      Location:1 → 348
      PTZ00103; 60S ribosomal protein L3; Provisional

    2. XM_017317609.3 → XP_017173098.1  large ribosomal subunit protein uL3-like isoform X1

      Conserved Domains (1) summary
      PTZ00103
      Location:1 → 348
      PTZ00103; 60S ribosomal protein L3; Provisional

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_019796.1: Suppressed sequence

      Description
      NG_019796.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9PWZ3.1 GenPept UniProtKB/Swiss-Prot:E9PWZ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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