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    FCAMR Fc alpha and mu receptor [ Homo sapiens (human) ]

    Gene ID: 83953, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FCAMRprovided by HGNC
    Official Full Name
    Fc alpha and mu receptorprovided by HGNC
    Primary source
    HGNC:HGNC:24692
    See related
    Ensembl:ENSG00000162897 MIM:605484; AllianceGenome:HGNC:24692
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD351; FCA/MR; FKSG87; Fcalpha/muR
    Summary
    Predicted to enable IgA binding activity; IgM binding activity; and transmembrane signaling receptor activity. Predicted to be involved in adaptive immune response. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney (RPKM 16.8), lymph node (RPKM 10.8) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FCAMR in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (206957967..206970638, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (206223168..206235839, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207131312..207143805, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1768 Neighboring gene negCOR silencer S10 Neighboring gene ribosomal protein L13a pseudogene 8 Neighboring gene Fc mu receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:207103683-207104183 Neighboring gene polymeric immunoglobulin receptor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1769 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207134913-207136112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2438 Neighboring gene tRNA-Pro (anticodon TGG) 5-1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207192892-207194091 Neighboring gene chromosome 1 open reading frame 116

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-Wide Association Studies for Taxane-Induced Peripheral Neuropathy in ECOG-5103 and ECOG-1199. Schneider BP, et al. Clin Cancer Res, 2015 Nov 15. PMID 26138065, Free PMC Article
    2. Immunoglobulin A in serum: an old acquaintance as a new prognostic biomarker in idiopathic pulmonary fibrosis. Ten Klooster L, et al. Clin Exp Immunol, 2015 Aug. PMID 25845491, Free PMC Article
    3. Expression of Fc alpha/mu receptor by human mesangial cells: a candidate receptor for immune complex deposition in IgA nephropathy. McDonald KJ, et al. Biochem Biophys Res Commun, 2002 Jan 11. PMID 11779189
    4. Cytoplasmic domain of human Fcalpha/mu receptor is required for ligand internalization. Yang L, et al. Cell Immunol, 2009. PMID 19393604
    5. Requirement of the cytoplasmic portion for dimer formation of Fcalpha/micro receptor expressed on cell surface. Cho Y, et al. Mol Immunol, 2010 Jan. PMID 19945166

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic pollution.
      Title: A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic.
    2. rs3125923 FCAMR gene represents a validated SNP to predict grade 3-4 Taxane-induced peripheral neuropathy . Genetically determined AA race represents the most significant predictor of TIPN.
      Title: Genome-Wide Association Studies for Taxane-Induced Peripheral Neuropathy in ECOG-5103 and ECOG-1199.
    3. A significantly worse survival was found in patients with IgA serum levels>2.85 g/l compared to patients with lower IgA serum levels.
      Title: Immunoglobulin A in serum: an old acquaintance as a new prognostic biomarker in idiopathic pulmonary fibrosis.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    5. ADAM10 and ADAM17 are involved in the shedding of FcalphaR
      Title: Ectodomain shedding of Fcalpha receptor is mediated by ADAM10 and ADAM17.
    6. LPS, through the TLR4 receptor, activates the p38MAPK and NF-kappaB pathways and up-regulate the expression of Fcamr in human macrophages
      Title: Lipopolysaccharide up-regulates the expression of Fcalpha/mu receptor and promotes the binding of oxidized low-density lipoprotein and its IgM antibody complex to activated human macrophages.
    7. These results suggest that the cytoplasmic portion is required for the dimer formation and thus for efficient cell surface expression of Fcalpha/microR.
      Title: Requirement of the cytoplasmic portion for dimer formation of Fcalpha/micro receptor expressed on cell surface.
    8. the cytoplasmic portion of human Fcalpha/microR is required in the internalization.
      Title: Cytoplasmic domain of human Fcalpha/mu receptor is required for ligand internalization.
    9. These results indicate for the first time that Fcalpha/muR protein is expressed by human intestinal tissues
      Title: Human Fcalpha/muR and pIgR distribute differently in intestinal tissues.
    10. Comprehensive survey of naturally occurring polymorphisms in rhesus macaques and in humans.
      Title: Human expression variation in the mu-opioid receptor is paralleled in rhesus macaque.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Preincubation of monocytes with HIV-1 gp120 depresses anti-CD3 antibody-induced T cell stimulation and Fc receptor-mediated phagocytosis PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor
    Names
    Fc alpha/mu receptor
    Fc fragment of IgA and IgM receptor
    Fc receptor, IgA, IgM, high affinity
    immunity related factor
    receptor for Fc fragment of IgA and IgM

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122979.3 → NP_001116451.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform a

      See identical proteins and their annotated locations for NP_001116451.1

      Status: VALIDATED

      Source sequence(s)
      AC098935, AI269147, BC109263, BX090153, CD633520
      Consensus CDS
      CCDS41460.1
      UniProtKB/Swiss-Prot
      Q8WWV6
      Related
      ENSP00000392707.2, ENST00000450945.3
      Conserved Domains (2) summary
      cd05716
      Location:114 → 214
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:112 → 215
      IG_like; Immunoglobulin like

    2. NM_001170631.2 → NP_001164102.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform b

      See identical proteins and their annotated locations for NP_001164102.1

      Status: VALIDATED

      Source sequence(s)
      AI269147, AK298394
      Consensus CDS
      CCDS53468.1
      UniProtKB/TrEMBL
      A0A0B4J1S2
      Related
      ENSP00000316491.4, ENST00000324852.9
      Conserved Domains (2) summary
      cd05716
      Location:114 → 214
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:112 → 215
      IG_like; Immunoglobulin like

    3. NM_001424868.1 → NP_001411797.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform c precursor

      Status: VALIDATED

      Description
      Transcript Variant: Contains an N-terminal signal peptide sequence (MPLFLILCLLQGSSFA) supported by SignalP as well as PMID: 11062505 and PMID: 20059578.
      Source sequence(s)
      AC098935
      UniProtKB/Swiss-Prot
      Q32M82, Q8WWV5, Q8WWV6, Q96SA2

    4. NM_032029.5 → NP_114418.2  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform a

      See identical proteins and their annotated locations for NP_114418.2

      Status: VALIDATED

      Source sequence(s)
      AC098935, AI269147, BC109263, BX090153, DC361666
      Consensus CDS
      CCDS41460.1
      UniProtKB/Swiss-Prot
      Q8WWV6
      Related
      ENSP00000383746.3, ENST00000400962.8
      Conserved Domains (2) summary
      cd05716
      Location:114 → 214
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:112 → 215
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      206957967..206970638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431769.1 → XP_047287725.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X1

      UniProtKB/TrEMBL
      A0A0B4J1S2

    2. XM_011510051.3 → XP_011508353.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X1

      See identical proteins and their annotated locations for XP_011508353.1

      UniProtKB/TrEMBL
      A0A0B4J1S2
      Conserved Domains (2) summary
      cd05716
      Location:114 → 214
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:112 → 215
      IG_like; Immunoglobulin like

    3. XM_047431771.1 → XP_047287727.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X3

    4. XM_011510052.3 → XP_011508354.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X2

      Conserved Domains (2) summary
      cd05716
      Location:102 → 202
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:100 → 203
      IG_like; Immunoglobulin like

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      206223168..206235839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339061.1 → XP_054195036.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X1

      UniProtKB/TrEMBL
      A0A0B4J1S2

    2. XM_054339063.1 → XP_054195038.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X3

    3. XM_054339062.1 → XP_054195037.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001122980.1: Suppressed sequence

      Description
      NM_001122980.1: This RefSeq was permanently suppressed because it represents a transcript produced via non-consensus splicing and there is limited support for that atypical event.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WWV6.1 GenPept UniProtKB/Swiss-Prot:Q8WWV6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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