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    LGALS7 galectin 7 [ Homo sapiens (human) ]

    Gene ID: 3963, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LGALS7provided by HGNC
    Official Full Name
    galectin 7provided by HGNC
    Primary source
    HGNC:HGNC:6568
    See related
    Ensembl:ENSG00000205076 MIM:600615; AllianceGenome:HGNC:6568
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GAL7; LGALS7A
    Summary
    The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:653499) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward skin (RPKM 300.6) See more
    Orthologs
    mouse all
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    Genomic context

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    See LGALS7 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (38770968..38773517, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (41575026..41577575, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39261608..39264157, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene actinin alpha 4 Neighboring gene uncharacterized LOC107985291 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39193145-39193645 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39195255-39196024 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:39198444-39199230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39208396-39209241 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39209276-39209996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39217269-39218152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14592 Neighboring gene uncharacterized LOC124904711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10581 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10582 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14593 Neighboring gene calpain 12 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10583 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39283071-39283770 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:39287723-39288637 Neighboring gene galectin 7B Neighboring gene RNA, U6 small nuclear 140, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Galectin-7 acts as an adhesion molecule during implantation and increased expression is associated with miscarriage. Menkhorst EM, et al. Placenta, 2014 Mar. PMID 24522232
    2. Galectin-7 Impairs Placentation and Causes Preeclampsia Features in Mice. Menkhorst E, et al. Hypertension, 2020 Oct. PMID 32862708
    3. Pro4 prolyl peptide bond isomerization in human galectin-7 modulates the monomer-dimer equilibrum to affect function. Miller MC, et al. Biochem J, 2020 Sep 18. PMID 32766716, Free PMC Article
    4. Protective role of Galectin-7 for skin barrier impairment in atopic dermatitis. Umayahara T, et al. Clin Exp Allergy, 2020 Aug. PMID 32474952, Free PMC Article
    5. A potential contribution of decreased galectin-7 expression in stratified epithelia to the development of cutaneous and oesophageal manifestations in systemic sclerosis. Saigusa R, et al. Exp Dermatol, 2019 May. PMID 30739341

    See all (126) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ANGPTL4 plays a paradoxical role in gastric cancer through the LGALS7 and Hedgehog pathways.
      Title: ANGPTL4 plays a paradoxical role in gastric cancer through the LGALS7 and Hedgehog pathways.
    2. Galectin-7 Expression in the Placentas of Women with Gestational Diabetes Mellitus.
      Title: Galectin-7 Expression in the Placentas of Women with Gestational Diabetes Mellitus.
    3. Galectin-7 Induction by EHMT2 Inhibition Enhances Immunity in Microsatellite Stability Colorectal Cancer.
      Title: Galectin-7 Induction by EHMT2 Inhibition Enhances Immunity in Microsatellite Stability Colorectal Cancer.
    4. Binding of Glycerol to Human Galectin-7 Expands Stability and Modulates Its Functions.
      Title: Binding of Glycerol to Human Galectin-7 Expands Stability and Modulates Its Functions.
    5. Interaction of Gal-7 with HMGCS1 In Vitro May Facilitate Cholesterol Deposition in Cultured Keratinocytes.
      Title: Interaction of Gal-7 with HMGCS1 In Vitro May Facilitate Cholesterol Deposition in Cultured Keratinocytes.
    6. CCCTC-binding factor transcriptionally regulates Galectin-7 and activates the JNK/STAT3 axis to aggravate bronchial epithelial cell injury.
      Title: CCCTC-binding factor transcriptionally regulates Galectin-7 and activates the JNK/STAT3 axis to aggravate bronchial epithelial cell injury.
    7. Perturbing dimer interactions and allosteric communication modulates the immunosuppressive activity of human galectin-7.
      Title: Perturbing dimer interactions and allosteric communication modulates the immunosuppressive activity of human galectin-7.
    8. Proteomic analysis shows that the main constituent of subepidermal localised cutaneous amyloidosis is not galectin-7.
      Title: Proteomic analysis shows that the main constituent of subepidermal localised cutaneous amyloidosis is not galectin-7.
    9. Protective role of Galectin-7 for skin barrier impairment in atopic dermatitis.
      Title: Protective role of Galectin-7 for skin barrier impairment in atopic dermatitis.
    10. Imitating evolution's tinkering by protein engineering reveals extension of human galectin-7 activity.
      Title: Imitating evolution's tinkering by protein engineering reveals extension of human galectin-7 activity.
    Submit: New GeneRIF Correction See all GeneRIFs (61)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    galectin-7
    Names
    lectin, galactoside-binding, soluble, 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002307.4 → NP_002298.1  galectin-7

      See identical proteins and their annotated locations for NP_002298.1

      Status: REVIEWED

      Source sequence(s)
      BP225960
      Consensus CDS
      CCDS33012.1
      UniProtKB/Swiss-Prot
      P47929, Q6IB87
      Related
      ENSP00000367891.3, ENST00000378626.5
      Conserved Domains (1) summary
      smart00908
      Location:11 → 133
      Gal-bind_lectin; Galactoside-binding lectin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      38770968..38773517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_014040929.1 Reference GRCh38.p14 PATCHES

      Range
      180608..183157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      41575026..41577575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321017.1 → XP_054176992.1  galectin-7 isoform X1

    Nucleotide Protein
    Heading Accession and Version

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