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    Y48C3A.18 Threonylcarbamoyl-AMP synthase [ Caenorhabditis elegans ]

    Gene ID: 174981, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Y48C3A.18
    Official Full Name
    Threonylcarbamoyl-AMP synthase
    Primary source
    WormBase:WBGene00012997
    Locus tag
    CELE_Y48C3A.18
    See related
    AllianceGenome:WB:WBGene00012997
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable nucleotidyltransferase activity and tRNA binding activity. Predicted to be involved in regulation of translational fidelity. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome. Orthologous to human YRDC (yrdC N6-threonylcarbamoyltransferase domain containing). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See Y48C3A.18 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (13412635..13414906)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Peptidyl-prolyl cis-trans isomerase Neighboring gene Transcription factor efl-2 Neighboring gene Centromere protein S;Eukaryotic translation initiation factor 3 30 kDa subunit Neighboring gene Carnosine N-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables double-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of translational fidelity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Threonylcarbamoyl-AMP synthase
    NP_001122661.2
    • Partially confirmed by transcript evidence
    NP_001254385.1
    • Confirmed by transcript evidence
    NP_496826.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13412635..13414906
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064425.4 → NP_496826.2  Threonylcarbamoyl-AMP synthase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496826.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NAF8
      Conserved Domains (1) summary
      pfam01300
      Location:28 → 197
      Sua5_yciO_yrdC; Telomere recombination

    2. NM_001129189.4 → NP_001122661.2  Threonylcarbamoyl-AMP synthase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122661.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5HWA9
      Conserved Domains (1) summary
      cl00305
      Location:9 → 124
      Sua5_yciO_yrdC; Telomere recombination

    3. NM_001267456.3 → NP_001254385.1  Threonylcarbamoyl-AMP synthase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254385.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G2HK06
      Conserved Domains (1) summary
      cl00305
      Location:8 → 100
      Sua5_yciO_yrdC; Telomere recombination
    Nucleotide Protein
    Heading Accession and Version

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