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    his-72 Histone H3.3 type 2 [ Caenorhabditis elegans ]

    Gene ID: 176660, updated on 2-Nov-2024

    Summary

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    Official Symbol
    his-72
    Official Full Name
    Histone H3.3 type 2
    Primary source
    WormBase:WBGene00001946
    Locus tag
    CELE_Y49E10.6
    See related
    AllianceGenome:WB:WBGene00001946
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Located in nucleus. Part of nucleosome. Is expressed in several structures, including male. Orthologous to several human genes including H3-3A (H3.3 histone A) and H3-3B (H3.3 histone B). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See his-72 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (12367475..12369050, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DUF221-domain-containing protein Neighboring gene ncRNA Neighboring gene 26S proteasome regulatory subunit 8 Neighboring gene Glutaredoxin domain-containing protein Neighboring gene Serine/threonine-protein phosphatase 4 catalytic subunit 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A native chromatin purification system for epigenomic profiling in Caenorhabditis elegans. Ooi SL, et al. Nucleic Acids Res, 2010 Mar. PMID 19966274, Free PMC Article
    2. Endogenous expression and localization of HIS-72::mTurquoise2 in C. elegans. Sloan DE, et al. MicroPubl Biol, 2021. PMID 34604717, Free PMC Article
    3. A Chemoptogenetic Tool for Spatiotemporal Induction of Oxidative DNA Lesions In Vivo. Han S, et al. Genes (Basel), 2023 Feb 14. PMID 36833412, Free PMC Article
    4. Mitochondrial DNA level, but not active replicase, is essential for Caenorhabditis elegans development. Bratic I, et al. Nucleic Acids Res, 2009 Apr. PMID 19181702, Free PMC Article
    5. Histone H3.3 variant dynamics in the germline of Caenorhabditis elegans. Ooi SL, et al. PLoS Genet, 2006 Jun. PMID 16846252, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Histone H3.3 type 2
    NP_001255162.1
    • Confirmed by transcript evidence
    NP_001255163.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12367475..12369050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268234.5 → NP_001255163.1  Histone H3.3 type 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255163.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P08898, Q9TW44, Q9U281
      Conserved Domains (1) summary
      PTZ00018
      Location:1 → 136
      PTZ00018; histone H3; Provisional

    2. NM_001268233.3 → NP_001255162.1  Histone H3.3 type 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255162.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L2K8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U281.3

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