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    GPRIN2 G protein regulated inducer of neurite outgrowth 2 [ Homo sapiens (human) ]

    Gene ID: 9721, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GPRIN2provided by HGNC
    Official Full Name
    G protein regulated inducer of neurite outgrowth 2provided by HGNC
    Primary source
    HGNC:HGNC:23730
    See related
    Ensembl:ENSG00000204175 MIM:611240; AllianceGenome:HGNC:23730
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GRIN2; KIAA0514
    Summary
    Predicted to be involved in neuron projection development. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: suggests misassembly
    Expression
    Biased expression in lung (RPKM 5.6), skin (RPKM 4.9) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPRIN2 in Genome Data Viewer
    Location:
    10q11.22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (46541736..46557596, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (47428090..47443951, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (46992021..47007881)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 842 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 33 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47124851-47125351 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47124350-47124850 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:47107598-47108554 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47101901-47102401 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:47089605-47090205 Neighboring gene neuropeptide Y receptor Y4 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:47033702-47034570 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47034571-47035439 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47047925-47048424 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:47057528-47058124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47021543-47022511 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47013295-47013796 Neighboring gene uncharacterized LOC124902419 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:47008064-47008694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:46992923-46993628 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:46991512-46992217 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:46975535-46976296 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:46974774-46975534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:46974012-46974773 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:46969747-46970624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:46968867-46969746 Neighboring gene Sharpr-MPRA regulatory regions 2784 and 8617 duplicate 1 Neighboring gene SYT15 antisense RNA 1 Neighboring gene uncharacterized LOC105378289 Neighboring gene synaptotagmin 15 Neighboring gene shieldin complex subunit 2 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Familial Esophageal Squamous Cell Carcinoma with damaging rare/germline mutations in KCNJ12/KCNJ18 and GPRIN2 genes. Khalilipour N, et al. Cancer Genet, 2018 Feb. PMID 29405996
    2. Identification and biochemical analysis of GRIN1 and GRIN2. Iida N, et al. Methods Enzymol, 2004. PMID 15488195
    3. A candidate target for G protein action in brain. Chen LT, et al. J Biol Chem, 1999 Sep 17. PMID 10480904
    4. Protein interactions of the transcription factor Hoxa1. Lambert B, et al. BMC Dev Biol, 2012 Oct 22. PMID 23088713, Free PMC Article
    5. Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. Benzinger A, et al. Mol Cell Proteomics, 2005 Jun. PMID 15778465

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC15171

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G protein-regulated inducer of neurite outgrowth 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001385275.1 → NP_001372204.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Consensus CDS
      CCDS73101.1
      UniProtKB/Swiss-Prot
      O60269, Q5SVF0
      Conserved Domains (1) summary
      pfam15235
      Location:349 → 450
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    2. NM_001385276.1 → NP_001372205.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Consensus CDS
      CCDS73101.1
      UniProtKB/Swiss-Prot
      O60269, Q5SVF0
      Conserved Domains (1) summary
      pfam15235
      Location:349 → 450
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    3. NM_001385277.1 → NP_001372206.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Consensus CDS
      CCDS73101.1
      UniProtKB/Swiss-Prot
      O60269, Q5SVF0
      Conserved Domains (1) summary
      pfam15235
      Location:349 → 450
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    4. NM_001385278.1 → NP_001372207.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Consensus CDS
      CCDS73101.1
      UniProtKB/Swiss-Prot
      O60269, Q5SVF0
      Related
      ENSP00000363436.1, ENST00000374317.2
      Conserved Domains (1) summary
      pfam15235
      Location:349 → 450
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    5. NM_001385279.1 → NP_001372208.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Consensus CDS
      CCDS73101.1
      UniProtKB/Swiss-Prot
      O60269, Q5SVF0
      Conserved Domains (1) summary
      pfam15235
      Location:349 → 450
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    6. NM_001385280.1 → NP_001372209.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Consensus CDS
      CCDS73101.1
      UniProtKB/Swiss-Prot
      O60269, Q5SVF0
      Conserved Domains (1) summary
      pfam15235
      Location:349 → 450
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    7. NM_001385281.1 → NP_001372210.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Consensus CDS
      CCDS73101.1
      UniProtKB/Swiss-Prot
      O60269, Q5SVF0
      Conserved Domains (1) summary
      pfam15235
      Location:349 → 450
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    8. NM_001385282.1 → NP_001372211.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Consensus CDS
      CCDS73101.1
      UniProtKB/Swiss-Prot
      O60269, Q5SVF0
      Related
      ENSP00000363433.4, ENST00000374314.6
      Conserved Domains (1) summary
      pfam15235
      Location:349 → 450
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    9. NM_001385283.1 → NP_001372212.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Consensus CDS
      CCDS73101.1
      UniProtKB/Swiss-Prot
      O60269, Q5SVF0
      Conserved Domains (1) summary
      pfam15235
      Location:349 → 450
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    10. NM_001385287.1 → NP_001372216.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    11. NM_001385289.1 → NP_001372218.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    12. NM_001385291.1 → NP_001372220.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    13. NM_001385293.1 → NP_001372222.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    14. NM_001385294.1 → NP_001372223.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    15. NM_001385295.1 → NP_001372224.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    16. NM_001385296.1 → NP_001372225.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    17. NM_001385297.1 → NP_001372226.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    18. NM_001385298.1 → NP_001372227.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    19. NM_001385299.1 → NP_001372228.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    20. NM_001385300.1 → NP_001372229.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    21. NM_001385301.1 → NP_001372230.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    22. NM_001394739.1 → NP_001381668.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Consensus CDS
      CCDS73101.1
      UniProtKB/Swiss-Prot
      O60269, Q5SVF0
      Conserved Domains (1) summary
      pfam15235
      Location:349 → 450
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    23. NM_001394740.1 → NP_001381669.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Consensus CDS
      CCDS73101.1
      UniProtKB/Swiss-Prot
      O60269, Q5SVF0
      Conserved Domains (1) summary
      pfam15235
      Location:349 → 450
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    24. NM_001394741.1 → NP_001381670.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Consensus CDS
      CCDS73101.1
      UniProtKB/Swiss-Prot
      O60269, Q5SVF0
      Conserved Domains (1) summary
      pfam15235
      Location:349 → 450
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    25. NM_001394742.1 → NP_001381671.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    26. NM_001394743.1 → NP_001381672.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    27. NM_001394744.1 → NP_001381673.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    28. NM_014696.5 → NP_055511.2  G protein-regulated inducer of neurite outgrowth 2 isoform 1

      See identical proteins and their annotated locations for NP_055511.2

      Status: VALIDATED

      Source sequence(s)
      AL356056, AL645529, AL732434
      Consensus CDS
      CCDS73101.1
      UniProtKB/Swiss-Prot
      O60269, Q5SVF0
      Conserved Domains (1) summary
      pfam15235
      Location:349 → 450
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      46541736..46557596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016981.3 → XP_016872470.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    2. XM_017016982.3 → XP_016872471.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    3. XM_017016974.3 → XP_016872463.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    4. XM_017016984.3 → XP_016872473.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    5. XM_017016983.3 → XP_016872472.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    6. XM_017016976.3 → XP_016872465.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    7. XM_017016977.3 → XP_016872466.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    8. XM_017016975.3 → XP_016872464.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    9. XM_017016978.3 → XP_016872467.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

      Conserved Domains (1) summary
      pfam15235
      Location:373 → 474
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160001.1 Reference GRCh38.p14 PATCHES

      Range
      45021..60864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      47428090..47443951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367243.1 → XP_054223218.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

    2. XM_054367242.1 → XP_054223217.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

    3. XM_054367241.1 → XP_054223216.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

    4. XM_054367240.1 → XP_054223215.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60269.2 GenPept UniProtKB/Swiss-Prot:O60269

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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