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    RARRES1 retinoic acid receptor responder 1 [ Homo sapiens (human) ]

    Gene ID: 5918, updated on 14-Nov-2024

    Summary

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    Official Symbol
    RARRES1provided by HGNC
    Official Full Name
    retinoic acid receptor responder 1provided by HGNC
    Primary source
    HGNC:HGNC:9867
    See related
    Ensembl:ENSG00000118849 MIM:605090; AllianceGenome:HGNC:9867
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LXNL; TIG1; PERG-1
    Summary
    This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in appendix (RPKM 33.7), urinary bladder (RPKM 25.5) and 17 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RARRES1 in Genome Data Viewer
    Location:
    3q25.32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (158696892..158732457, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (161470815..161506388, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (158414681..158450246, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:158344231-158344732 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:158344733-158345232 Neighboring gene RFK pseudogene 6 Neighboring gene G elongation factor mitochondrial 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:158389654-158390246 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:158390247-158390839 Neighboring gene latexin Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:158430992-158432191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:158433310-158433810 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:158447157-158447335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14848 Neighboring gene uncharacterized LOC100287290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:158450198-158450698 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:158478422-158478617 Neighboring gene VISTA enhancer hs1990 Neighboring gene ribosomal protein L35a pseudogene 9 Neighboring gene major facilitator superfamily domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RARRES1 identified by comprehensive bioinformatic analysis and experimental validation as a promising biomarker in Skin Cutaneous Melanoma. Liu M, et al. Sci Rep, 2024 Jun 19. PMID 38898266, Free PMC Article
    2. Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin. Nagpal S, et al. J Invest Dermatol, 1996 Feb. PMID 8601727
    3. Tazarotene-induced gene 1 (TIG1) expression in prostate carcinomas and its relationship to tumorigenicity. Jing C, et al. J Natl Cancer Inst, 2002 Apr 3. PMID 11929948
    4. Hypermethylation and silencing of the putative tumor suppressor Tazarotene-induced gene 1 in human cancers. Youssef EM, et al. Cancer Res, 2004 Apr 1. PMID 15059893
    5. Involvement of tazarotene-induced gene 1 in proliferation and differentiation of human adipose tissue-derived mesenchymal stem cells. Ohnishi S, et al. Cell Prolif, 2009 Jun. PMID 19250291, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Podocyte-derived soluble RARRES1 drives kidney disease progression through direct podocyte and proximal tubular injury.
      Title: Podocyte-derived soluble RARRES1 drives kidney disease progression through direct podocyte and proximal tubular injury.
    2. RARRES1 identified by comprehensive bioinformatic analysis and experimental validation as a promising biomarker in Skin Cutaneous Melanoma.
      Title: RARRES1 identified by comprehensive bioinformatic analysis and experimental validation as a promising biomarker in Skin Cutaneous Melanoma.
    3. Tazarotene-induced Gene 1 Induces Melanoma Cell Death by Triggering Endoplasmic Reticulum Stress Response.
      Title: Tazarotene-induced Gene 1 Induces Melanoma Cell Death by Triggering Endoplasmic Reticulum Stress Response.
    4. GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion.
      Title: GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion.
    5. TIG1 Inhibits the mTOR Signaling Pathway in Malignant Melanoma Through the VAC14 Protein.
      Title: TIG1 Inhibits the mTOR Signaling Pathway in Malignant Melanoma Through the VAC14 Protein.
    6. Interaction of RARRES1 with ICAM1 modulates macrophages to suppress the progression of kidney renal clear cell carcinoma.
      Title: Interaction of RARRES1 with ICAM1 modulates macrophages to suppress the progression of kidney renal clear cell carcinoma.
    7. Involvement of miR-769-5p/Retinoic Acid Receptor Responder 1 Axis in the Progression of Osteosarcoma: Characterization of Potential Therapeutic Targets.
      Title: Involvement of miR-769-5p/Retinoic Acid Receptor Responder 1 Axis in the Progression of Osteosarcoma: Characterization of Potential Therapeutic Targets.
    8. Tazarotene-induced gene 1 interacts with Polo-like kinase 2 and inhibits cell proliferation in HCT116 colorectal cancer cells.
      Title: Tazarotene-induced gene 1 interacts with Polo-like kinase 2 and inhibits cell proliferation in HCT116 colorectal cancer cells.
    9. Autocrine and paracrine effects of a novel podocyte gene, RARRES1.
      Title: Autocrine and paracrine effects of a novel podocyte gene, RARRES1.
    10. Cathepsin V Mediates the Tazarotene-induced Gene 1-induced Reduction in Invasion in Colorectal Cancer Cells.
      Title: Cathepsin V Mediates the Tazarotene-induced Gene 1-induced Reduction in Invasion in Colorectal Cancer Cells.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metalloendopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    retinoic acid receptor responder protein 1
    Names
    RAR-responsive protein TIG1
    latexin-like
    phorbol ester-induced gene 1 protein
    retinoic acid receptor responder (tazarotene induced) 1
    tazarotene-induced gene 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002888.4 → NP_002879.2  retinoic acid receptor responder protein 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_002879.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' end-region compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC080013, BC029640, BM919188
      Consensus CDS
      CCDS54665.1
      UniProtKB/Swiss-Prot
      P49788
      Related
      ENSP00000418556.1, ENST00000479756.1
      Conserved Domains (1) summary
      pfam06907
      Location:52 → 227
      Latexin; Latexin

    2. NM_206963.2 → NP_996846.1  retinoic acid receptor responder protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_996846.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. It encodes the longer isoform (1).
      Source sequence(s)
      AC080013, AK130079, BC029640, BM919188
      Consensus CDS
      CCDS3184.1
      UniProtKB/Swiss-Prot
      P49788, Q8N1D7
      Related
      ENSP00000237696.5, ENST00000237696.10
      Conserved Domains (1) summary
      pfam06907
      Location:52 → 274
      Latexin; Latexin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      158696892..158732457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005247686.6 → XP_005247743.4  retinoic acid receptor responder protein 1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      161470815..161506388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347419.1 → XP_054203394.1  retinoic acid receptor responder protein 1 isoform X1

    RNA

    1. XR_008486768.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49788.2 GenPept UniProtKB/Swiss-Prot:P49788

    Gene LinkOut

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