WSB2 WD repeat and SOCS box containing 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: WSB2provided by HGNC
Official Full Name: WD repeat and SOCS box containing 2provided by HGNC
Primary source: HGNC:HGNC:19222
See related: Ensembl:ENSG00000176871 AllianceGenome:HGNC:19222
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SBA2
Summary: This gene encodes a member of the WD-protein subfamily. The encoded protein contains five WD-repeats spanning most of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquitin protein ligases. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Expression: Ubiquitous expression in brain (RPKM 65.4), thyroid (RPKM 28.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q24.23

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (118032687..118062174, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (118019987..118049474, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (118470492..118499979, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WSB1/2 target chromatin-bound lysine-methylated RelA for proteasomal degradation and NF-kappaB termination.
Title: WSB1/2 target chromatin-bound lysine-methylated RelA for proteasomal degradation and NF-κB termination.
Elevated expression of WSB2 degrades p53 and activates the IGFBP3-AKT-mTOR-dependent pathway to drive hepatocellular carcinoma.
Title: Elevated expression of WSB2 degrades p53 and activates the IGFBP3-AKT-mTOR-dependent pathway to drive hepatocellular carcinoma.
miR285p inhibits the migration of breast cancer by regulating WSB2.
Title: miR‑28‑5p inhibits the migration of breast cancer by regulating WSB2.
This is the first report to demonstrate the effects of WSB2 on melanoma cell function.
Title: WD repeat and SOCS box containing protein 2 in the proliferation, cycle progression, and migration of melanoma cells.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
This report provides the first evidence that WSB-2 is a regulator of IL-21R expression and IL-21-induced signal transduction.
Title: Regulation of interleukin-21 receptor expression and its signal transduction by WSB-2.
SBA2 gene might be a promising novel biomarker of cell differentiation in colorectal cancer and its biological features need further studies.
Title: Differential expression of a novel colorectal cancer differentiation-related gene in colorectal cancer.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of WD repeat and SOCS box containing 2 (WSB2) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12S1213E (e-PCR)
- UniSTS:32877

SHGC-67307 (e-PCR)
- UniSTS:89991

Bdaa5h08 (e-PCR)
- UniSTS:88982

HUMHM01G06 (e-PCR)
- UniSTS:77985

D12S1776 (e-PCR)
- UniSTS:78807

WI-13177 (e-PCR)
- UniSTS:66801

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: WD repeat and SOCS box-containing protein 2

Names: CS box-containing WD protein; WSB-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001278557.1 → NP_001265486.1 WD repeat and SOCS box-containing protein 2 isoform 1

See identical proteins and their annotated locations for NP_001265486.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC131159, AF229181, AK295555, CA443120

Consensus CDS

CCDS61252.1

UniProtKB/Swiss-Prot

Q9NYS7

Related

ENSP00000409131.2, ENST00000441406.6

Conserved Domains (4) summary

COG2319
Location:47 → 384

WD40; WD40 repeat [General function prediction only]

cd00200
Location:138 → 377

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd03733
Location:381 → 419

SOCS_WSB_SWIP; SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 ...

sd00039
Location:174 → 212

7WD40; WD40 repeat [structural motif]
NM_001278558.2 → NP_001265487.1 WD repeat and SOCS box-containing protein 2 isoform 3

See identical proteins and their annotated locations for NP_001265487.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks two internal exons compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC131159, AF229181, AK298513, CA443120, DA772463

Consensus CDS

CCDS61251.1

UniProtKB/TrEMBL

B4DFS1

Related

ENSP00000444431.1, ENST00000544233.5

Conserved Domains (3) summary

cd03733
Location:154 → 192

SOCS_WSB_SWIP; SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 ...

sd00039
Location:32 → 68

7WD40; WD40 repeat [structural motif]

cl29593
Location:1 → 150

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_018639.5 → NP_061109.1 WD repeat and SOCS box-containing protein 2 isoform 2

See identical proteins and their annotated locations for NP_061109.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC131159, AF229181, CA443120, DA772463

Consensus CDS

CCDS9186.1

UniProtKB/Swiss-Prot

B4DIE6, B4DPV6, Q9NRX9, Q9NYS7

Related

ENSP00000319474.3, ENST00000315436.8

Conserved Domains (3) summary

cd00200
Location:121 → 360

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd03733
Location:364 → 402

SOCS_WSB_SWIP; SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 ...

sd00039
Location:157 → 195

7WD40; WD40 repeat [structural motif]