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    SELENOP selenoprotein P [ Homo sapiens (human) ]

    Gene ID: 6414, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SELENOPprovided by HGNC
    Official Full Name
    selenoprotein Pprovided by HGNC
    Primary source
    HGNC:HGNC:10751
    See related
    Ensembl:ENSG00000250722 MIM:601484; AllianceGenome:HGNC:10751
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SeP; SELP; SEPP; SEPP1
    Summary
    This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. The use of alternative polyadenylation sites, one located in between the two SECIS elements, results in two populations of mRNAs containing either both (predominant) or just the upstream SECIS element (PMID:27881738). Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2018]
    Expression
    Broad expression in liver (RPKM 1192.8), small intestine (RPKM 1057.6) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SELENOP in Genome Data Viewer
    Location:
    5p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (42799880..42811892, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (43052823..43064836, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (42799982..42811994, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2996 Neighboring gene NANOG hESC enhancer GRCh37_chr5:42225166-42225693 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85146 Neighboring gene NANOG hESC enhancer GRCh37_chr5:42288621-42289193 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85179 Neighboring gene GHR upstream promoter region module A Neighboring gene zinc finger protein 35 pseudogene Neighboring gene SERPINE1 mRNA binding protein 1 pseudogene 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:42508817-42509317 Neighboring gene growth hormone receptor Neighboring gene GHR downstream promoter region module B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:42756975-42757476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:42757477-42757976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:42804335-42804835 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:42803834-42804334 Neighboring gene coiled-coil domain containing 152 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:42812153-42812718 Neighboring gene uncharacterized LOC124900970 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:42847432-42847604 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:42886955-42888154 Neighboring gene peptidylprolyl isomerase A pseudogene 77

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Sex-specific and inter-individual differences in biomarkers of selenium status identified by a calibrated ELISA for selenoprotein P. Hybsier S, et al. Redox Biol, 2017 Apr. PMID 28064116, Free PMC Article
    2. Selenoprotein P is not elevated in gestational diabetes mellitus. Altinova AE, et al. Gynecol Endocrinol, 2015. PMID 26514640
    3. Selenoprotein P, rather than glutathione peroxidase, as a potential marker of septic shock and related syndromes. Forceville X, et al. Eur Surg Res, 2009. PMID 19779296
    4. The Synergistic Effect of Serine with Selenocompounds on the Expression of SelP and GPx in HepG2 Cells. Wang Q, et al. Biol Trace Elem Res, 2016 Oct. PMID 26944060
    5. [Overexpression of SEPP1 inhibits the proliferation and induces cell cycle G2/M arrest of 786-O and 769-P human renal carcinoma cells]. Liu K, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2016 Jun. PMID 27371843

    See all (144) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Selenoprotein P, peroxiredoxin-5, renalase, and total antioxidant status in patients with suspected obstructive sleep apnea.
      Title: Selenoprotein P, peroxiredoxin-5, renalase, and total antioxidant status in patients with suspected obstructive sleep apnea.
    2. Strong associations of serum selenoprotein P with all-cause mortality and mortality due to cancer, cardiovascular, respiratory and gastrointestinal diseases in older German adults.
      Title: Strong associations of serum selenoprotein P with all-cause mortality and mortality due to cancer, cardiovascular, respiratory and gastrointestinal diseases in older German adults.
    3. Association of Serum Selenium and Selenoprotein P with Oxidative Stress Biomarkers in Patients with Polycystic Ovary Syndrome.
      Title: Association of Serum Selenium and Selenoprotein P with Oxidative Stress Biomarkers in Patients with Polycystic Ovary Syndrome.
    4. Selenoprotein P expression in glioblastoma as a regulator of ferroptosis sensitivity: preservation of GPX4 via the cycling-selenium storage.
      Title: Selenoprotein P expression in glioblastoma as a regulator of ferroptosis sensitivity: preservation of GPX4 via the cycling-selenium storage.
    5. Selenoprotein P deficiency is associated with higher risk of incident heart failure.
      Title: Selenoprotein P deficiency is associated with higher risk of incident heart failure.
    6. SELENOP rs3877899 Variant Affects the Risk of Developing Advanced Stages of Retinopathy of Prematurity (ROP).
      Title: SELENOP rs3877899 Variant Affects the Risk of Developing Advanced Stages of Retinopathy of Prematurity (ROP).
    7. Autoantibodies to selenoprotein P in chronic fatigue syndrome suggest selenium transport impairment and acquired resistance to thyroid hormone.
      Title: Autoantibodies to selenoprotein P in chronic fatigue syndrome suggest selenium transport impairment and acquired resistance to thyroid hormone.
    8. SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions.
      Title: SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions.
    9. Lower Plasma Selenoprotein P Levels in Regularly Exercising Young Adults.
      Title: Lower Plasma Selenoprotein P Levels in Regularly Exercising Young Adults.
    10. The role of selenoprotein P in the determining the sensitivity of cervical cancer patients to concurrent chemoradiotherapy: A metabonomics-based analysis.
      Title: The role of selenoprotein P in the determining the sensitivity of cervical cancer patients to concurrent chemoradiotherapy: A metabonomics-based analysis.
    Submit: New GeneRIF Correction See all GeneRIFs (103)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of selenoprotein P (SEPP1) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables selenium binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress TAS
    Traceable Author Statement
    more info
    		  
    involved_in response to selenium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in selenium compound metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sexual reproduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in platelet dense granule lumen TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    selenoprotein P
    Names
    selenoprotein P, plasma, 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085486.3 → NP_001078955.1  selenoprotein P isoform 1 precursor

      See identical proteins and their annotated locations for NP_001078955.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as Sepp1c) contains an additional 5' non-coding exon, and thus has a different and longer 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      HM005482
      Consensus CDS
      CCDS43311.1
      UniProtKB/Swiss-Prot
      P49908, Q6PD59, Q6PI43, Q6PI87, Q6PJF9
      UniProtKB/TrEMBL
      A0A182DWH7
      Related
      ENSP00000427671.1, ENST00000511224.5
      Conserved Domains (2) summary
      pfam04592
      Location:23 → 243
      SelP_N; Selenoprotein P, N terminal region
      pfam04593
      Location:251 → 381
      SelP_C; Selenoprotein P, C terminal region

    2. NM_001093726.3 → NP_001087195.1  selenoprotein P isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as Sepp1b) contains an additional 5' coding exon compared to variant 1. It initiates translation from an in-frame, upstream start codon, which results in an isoform (2) with a longer and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL599162, BC040075, HM005482
      UniProtKB/Swiss-Prot
      P49908
      Conserved Domains (2) summary
      pfam04592
      Location:53 → 273
      SelP_N; Selenoprotein P, N terminal region
      pfam04593
      Location:281 → 411
      SelP_C; Selenoprotein P, C terminal region

    3. NM_005410.4 → NP_005401.3  selenoprotein P isoform 1 precursor

      See identical proteins and their annotated locations for NP_005401.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as Sepp1a) represents the predominant transcript and encodes isoform 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      BC040075, DA288385, HM005482
      Consensus CDS
      CCDS43311.1
      UniProtKB/Swiss-Prot
      P49908, Q6PD59, Q6PI43, Q6PI87, Q6PJF9
      UniProtKB/TrEMBL
      A0A182DWH7
      Related
      ENSP00000420939.1, ENST00000514985.6
      Conserved Domains (2) summary
      pfam04592
      Location:23 → 243
      SelP_N; Selenoprotein P, N terminal region
      pfam04593
      Location:251 → 381
      SelP_C; Selenoprotein P, C terminal region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      42799880..42811892 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      43052823..43064836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49908.3 GenPept UniProtKB/Swiss-Prot:P49908

    Gene LinkOut

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