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    COMMD3-BMI1 COMMD3-BMI1 readthrough [ Homo sapiens (human) ]

    Gene ID: 100532731, updated on 2-Nov-2024

    Summary

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    Official Symbol
    COMMD3-BMI1provided by HGNC
    Official Full Name
    COMMD3-BMI1 readthroughprovided by HGNC
    Primary source
    HGNC:HGNC:48326
    See related
    Ensembl:ENSG00000269897 AllianceGenome:HGNC:48326
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BMI1; PCGF4; RNF51
    Summary
    This locus represents naturally occurring read-through transcription between the neighboring COMM domain-containing protein 3 and polycomb complex protein BMI-1 genes on chromosome 10. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]
    Expression
    Ubiquitous expression in testis (RPKM 24.5), endometrium (RPKM 22.5) and 25 other tissues See more
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    Genomic context

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    See COMMD3-BMI1 in Genome Data Viewer
    Location:
    10p12.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (22316388..22331484)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (22335422..22350518)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (22605317..22620413)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376447 Neighboring gene uncharacterized LOC100130992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2202 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:22542487-22543183 Neighboring gene ribosomal protein L31 pseudogene 45 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:22568695-22569196 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:22569197-22569696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3129 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2205 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2206 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2207 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2208 Neighboring gene COMM domain containing 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:22629212-22629998 Neighboring gene BMI1 proto-oncogene, polycomb ring finger Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:22634454-22635270 Neighboring gene sperm associated antigen 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3131 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:22697232-22697772 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:22697773-22698311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2210 Neighboring gene uncharacterized LOC105376449 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:22726272-22726772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:22726773-22727273 Neighboring gene long intergenic non-protein coding RNA 3027

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article
    2. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. Oliviero G, et al. Sci Rep, 2015 Dec 21. PMID 26687479, Free PMC Article
    3. Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy. Ohnstad AE, et al. EMBO J, 2020 Dec 15. PMID 33226137, Free PMC Article
    4. A High-Density Map for Navigating the Human Polycomb Complexome. Hauri S, et al. Cell Rep, 2016 Oct 4. PMID 27705803
    5. HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation. Yuan J, et al. Cell Mol Gastroenterol Hepatol, 2023. PMID 36244648, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp434I153

    General protein information

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    Preferred Names
    COMMD3-BMI1 read-through protein
    Names
    Polycomb complex protein BMI-1
    Polycomb group RING finger protein 4
    RING finger protein 51

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204062.2 → NP_001190991.1  COMMD3-BMI1 read-through protein

      Status: VALIDATED

      Source sequence(s)
      AK313235, AL158211
      UniProtKB/TrEMBL
      R4GMX3
      Related
      ENSP00000473391.1, ENST00000602390.5
      Conserved Domains (3) summary
      pfam00097
      Location:161 → 199
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam07258
      Location:20 → 125
      HCaRG; HCaRG protein
      pfam16207
      Location:291 → 369
      RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      22316388..22331484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      22335422..22350518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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