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    HIPK2 homeodomain interacting protein kinase 2 [ Halichoerus grypus (gray seal) ]

    Gene ID: 118552448, updated on 20-Mar-2024

    Summary

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    Gene symbol
    HIPK2
    Gene description
    homeodomain interacting protein kinase 2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Halichoerus grypus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae; Halichoerus
    Orthologs
    human mouse all
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    Genomic context

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    See HIPK2 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    100 current Tufts_HGry_1.1 (GCF_012393455.1) Unplaced Scaffold NW_023397607.1 (636984..821185, complement)

    NW_023397607.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118550150 Neighboring gene 40S ribosomal protein S11-like Neighboring gene C-type lectin domain family 2 member L Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC118518834 Neighboring gene uncharacterized LOC118521714 Neighboring gene uncharacterized LOC118519242 Neighboring gene thromboxane A synthase 1 Neighboring gene uncharacterized LOC118521277

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_023397607 Unplaced Scaffold Reference Tufts_HGry_1.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables SMAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-threonine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homeodomain-interacting protein kinase 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Halichoerus grypus Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Tufts_HGry_1.1

    Genomic

    1. NW_023397607.1 Reference Tufts_HGry_1.1

      Range
      636984..821185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036119981.1 → XP_035975874.1  homeodomain-interacting protein kinase 2 isoform X2

      Conserved Domains (2) summary
      PHA03307
      Location:1038 → 1182
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14227
      Location:183 → 537
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

    2. XM_036121315.1 → XP_035977208.1  homeodomain-interacting protein kinase 2 isoform X4

      Conserved Domains (1) summary
      cd14227
      Location:176 → 530
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

    3. XM_036119255.1 → XP_035975148.1  homeodomain-interacting protein kinase 2 isoform X1

      Conserved Domains (2) summary
      PHA03307
      Location:1004 → 1148
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14227
      Location:176 → 530
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

    4. XM_036120606.1 → XP_035976499.1  homeodomain-interacting protein kinase 2 isoform X3

      Conserved Domains (1) summary
      cd14227
      Location:176 → 530
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

    RNA

    1. XR_004926496.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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