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    Srsf2 serine and arginine-rich splicing factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 20382, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Srsf2provided by MGI
    Official Full Name
    serine and arginine-rich splicing factor 2provided by MGI
    Primary source
    MGI:MGI:98284
    See related
    Ensembl:ENSMUSG00000034120 AllianceGenome:MGI:98284
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SC35; MRF-1; Pr264; Sfrs2; Sfrs10; D11Wsu175e
    Summary
    The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Sep 2010]
    Expression
    Ubiquitous expression in ovary adult (RPKM 340.2), thymus adult (RPKM 275.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Srsf2 in Genome Data Viewer
    Location:
    11 E2; 11 81.49 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116740723..116744511, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116849897..116853675, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene matrix-remodelling associated 7 Neighboring gene STARR-seq mESC enhancer starr_31225 Neighboring gene STARR-positive B cell enhancer ABC_E7102 Neighboring gene STARR-positive B cell enhancer ABC_E4018 Neighboring gene STARR-positive B cell enhancer ABC_E2376 Neighboring gene methyltransferase like 23 Neighboring gene jumonji domain containing 6 Neighboring gene major facilitator superfamily domain containing 11 Neighboring gene STARR-seq mESC enhancer starr_31229 Neighboring gene mannoside acetylglucosaminyltransferase 5, isoenzyme B Neighboring gene STARR-seq mESC enhancer starr_31231 Neighboring gene predicted gene, 33829 Neighboring gene STARR-seq mESC enhancer starr_31232 Neighboring gene STARR-seq mESC enhancer starr_31233 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:116898528-116898729 Neighboring gene predicted gene 11728

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PARP inhibition leads to synthetic lethality with key splicing-factor mutations in myelodysplastic syndromes. Zhang F, et al. Br J Cancer, 2024 Jul. PMID 38806724,
    2. Molecular cloning and characterization of additional factors that bind to the interferon-alpha/beta response element B of the murine (2'-5')oligoadenylate synthetase ME-12 gene. Yan C, et al. Proc Natl Acad Sci U S A, 1992 Oct 1. PMID 1409578, Free PMC Article
    3. Repositioning of muscle-specific genes relative to the periphery of SC-35 domains during skeletal myogenesis. Moen PT Jr, et al. Mol Biol Cell, 2004 Jan. PMID 14617810, Free PMC Article
    4. SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition. Kim E, et al. Cancer Cell, 2015 May 11. PMID 25965569, Free PMC Article
    5. Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins. Lee SC, et al. Nat Med, 2016 Jun. PMID 27135740, Free PMC Article

    See all (114) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SRSF2 is essential for maintaining pancreatic beta-cell identity and regulating glucose homeostasis in mice.
      Title: SRSF2 is essential for maintaining pancreatic beta-cell identity and regulating glucose homeostasis in mice.
    2. PARP inhibition leads to synthetic lethality with key splicing-factor mutations in myelodysplastic syndromes.
      Title: PARP inhibition leads to synthetic lethality with key splicing-factor mutations in myelodysplastic syndromes.
    3. A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies.
      Title: A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies.
    4. SRSF2 mutation reduces polycythemia and impairs hematopoietic progenitor functions in JAK2V617F-driven myeloproliferative neoplasm.
      Title: SRSF2 mutation reduces polycythemia and impairs hematopoietic progenitor functions in JAK2V617F-driven myeloproliferative neoplasm.
    5. SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice.
      Title: SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice.
    6. SRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice.
      Title: SRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice.
    7. RUNX1 deficiency cooperates with SRSF2 mutation to induce multilineage hematopoietic defects characteristic of MDS.
      Title: RUNX1 deficiency cooperates with SRSF2 mutation to induce multilineage hematopoietic defects characteristic of MDS.
    8. Srsf2[P95H/+] co-operates with loss of TET2 to promote myeloid bias and initiate a chronic myelomonocytic leukemia-like disease in mice.
      Title: Srsf2(P95H/+) co-operates with loss of TET2 to promote myeloid bias and initiate a chronic myelomonocytic leukemia-like disease in mice.
    9. Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation.
      Title: Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation.
    10. Loss of SRSF2 triggers hepatic progenitor cell activation and tumor development in mice.
      Title: Loss of SRSF2 triggers hepatic progenitor cell activation and tumor development in mice.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pre-mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase C binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to vitamin E IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in interchromatin granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in interchromatin granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perichromatin fibrils IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perichromatin fibrils ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/arginine-rich splicing factor 2
    Names
    myelin regulatory factor 1
    putative myelin regulatory factor 1
    splicing component, 35 kDa
    splicing factor Sc35
    splicing factor, arginine/serine-rich 2 (SC-35)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011358.2 → NP_035488.1  serine/arginine-rich splicing factor 2

      See identical proteins and their annotated locations for NP_035488.1

      Status: REVIEWED

      Source sequence(s)
      AK086103, BG093253, CJ043688
      Consensus CDS
      CCDS25680.1
      UniProtKB/Swiss-Prot
      Q542L3, Q60701, Q62093
      Related
      ENSMUSP00000090059.7, ENSMUST00000092404.13
      Conserved Domains (1) summary
      cd12311
      Location:16 → 88
      RRM_SRSF2_SRSF8; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      116740723..116744511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245724.2 → XP_030101584.1  serine/arginine-rich splicing factor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q542L3, Q60701, Q62093
      Conserved Domains (1) summary
      cd12311
      Location:16 → 88
      RRM_SRSF2_SRSF8; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins

    2. XM_011248835.4 → XP_011247137.1  serine/arginine-rich splicing factor 2 isoform X1

      See identical proteins and their annotated locations for XP_011247137.1

      UniProtKB/Swiss-Prot
      Q542L3, Q60701, Q62093
      Conserved Domains (1) summary
      cd12311
      Location:16 → 88
      RRM_SRSF2_SRSF8; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins

    RNA

    1. XR_003949365.2 RNA Sequence

    2. XR_003949366.2 RNA Sequence

    3. XR_003949364.2 RNA Sequence

    4. XR_003949363.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62093.4 GenPept UniProtKB/Swiss-Prot:Q62093

    Gene LinkOut

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