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    Nup85 nucleoporin 85 [ Mus musculus (house mouse) ]

    Gene ID: 445007, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nup85provided by MGI
    Official Full Name
    nucleoporin 85provided by MGI
    Primary source
    MGI:MGI:3046173
    See related
    Ensembl:ENSMUSG00000020739 AllianceGenome:MGI:3046173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pcnt1; frount
    Summary
    Predicted to enable CCR2 chemokine receptor binding activity. Predicted to be a structural constituent of nuclear pore. Acts upstream of or within lamellipodium assembly and macrophage chemotaxis. Predicted to be located in cytosol; nucleus; and plasma membrane. Predicted to be part of nuclear pore outer ring. Predicted to colocalize with kinetochore. Is expressed in several structures, including blastocyst; cerebral cortex ventricular layer; early embryo; and extraembryonic component. Human ortholog(s) of this gene implicated in nephrotic syndrome type 17. Orthologous to human NUP85 (nucleoporin 85). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 39.0), CNS E11.5 (RPKM 38.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nup85 in Genome Data Viewer
    Location:
    11 E2; 11 80.87 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115455264..115474750)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115564432..115583924)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Jupiter microtubule associated homolog 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115374372-115374555 Neighboring gene STARR-positive B cell enhancer ABC_E470 Neighboring gene small ubiquitin-like modifier 2 Neighboring gene STARR-positive B cell enhancer ABC_E4015 Neighboring gene STARR-seq mESC enhancer starr_31164 Neighboring gene STARR-positive B cell enhancer ABC_E8882 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 3 Neighboring gene STARR-seq mESC enhancer starr_31165 Neighboring gene predicted gene, 25364 Neighboring gene mitchondrial ribosomal protein S7 Neighboring gene MIF4G domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NUP85 alleviates lipid metabolism and inflammation by regulating PI3K/AKT signaling pathway in nonalcoholic fatty liver disease. Wu YC, et al. Int J Biol Sci, 2024. PMID 38617542, Free PMC Article
    2. Deficient chaperone-mediated autophagy in macrophage aggravates inflammation of nonalcoholic steatohepatitis by targeting Nup85. Zhang M, et al. Liver Int, 2023 May. PMID 36912786
    3. Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties. Terashima Y, et al. Nat Commun, 2020 Jan 30. PMID 32001710, Free PMC Article
    4. Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis. Terashima Y, et al. Nat Immunol, 2005 Aug. PMID 15995708
    5. Peering through the pore: nuclear pore complex structure, assembly, and function. Suntharalingam M, et al. Dev Cell, 2003 Jun. PMID 12791264

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NUP85 alleviates lipid metabolism and inflammation by regulating PI3K/AKT signaling pathway in nonalcoholic fatty liver disease.
      Title: NUP85 alleviates lipid metabolism and inflammation by regulating PI3K/AKT signaling pathway in nonalcoholic fatty liver disease.
    2. Deficient chaperone-mediated autophagy in macrophage aggravates inflammation of nonalcoholic steatohepatitis by targeting Nup85.
      Title: Deficient chaperone-mediated autophagy in macrophage aggravates inflammation of nonalcoholic steatohepatitis by targeting Nup85.
    3. the chemokine signal regulator FROUNT is identified as a target to control tumor-associated macrophages.
      Title: Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties.
    4. FROUNT links activated CCR2 to the PI(3)K-Rac-lamellipodium protrusion cascade in monocyte chemotaxis
      Title: Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105225

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CCR2 chemokine receptor binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokine-mediated signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    acts_upstream_of_or_within lamellipodium assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within macrophage chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nephron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nephron development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nucleocytoplasmic transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of nuclear pore outer ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore outer ring ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore outer ring ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear pore complex protein Nup85
    Names
    85 kDa nucleoporin
    nucleoporin Nup85
    pericentrin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002929.4 → NP_001002929.3  nuclear pore complex protein Nup85

      See identical proteins and their annotated locations for NP_001002929.3

      Status: VALIDATED

      Source sequence(s)
      BC079856, BY032258, CF738553
      Consensus CDS
      CCDS25640.1
      UniProtKB/Swiss-Prot
      A2A9W9, A2A9X0, Q8R480, Q9CYI9
      Related
      ENSMUSP00000021085.5, ENSMUST00000021085.11
      Conserved Domains (1) summary
      pfam07575
      Location:53 → 606
      Nucleopor_Nup85; Nup85 Nucleoporin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115455264..115474750
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533670.5 → XP_006533733.1  nuclear pore complex protein Nup85 isoform X1

      Conserved Domains (1) summary
      pfam07575
      Location:53 → 598
      Nucleopor_Nup85; Nup85 Nucleoporin

    2. XM_006533671.4 → XP_006533734.1  nuclear pore complex protein Nup85 isoform X2

      Conserved Domains (1) summary
      pfam07575
      Location:31 → 584
      Nucleopor_Nup85; Nup85 Nucleoporin

    3. XM_030246116.2 → XP_030101976.1  nuclear pore complex protein Nup85 isoform X3

      Conserved Domains (1) summary
      pfam07575
      Location:31 → 576
      Nucleopor_Nup85; Nup85 Nucleoporin

    RNA

    1. XR_004936985.1 RNA Sequence

    2. XR_388489.5 RNA Sequence

    3. XR_004936986.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R480.1 GenPept UniProtKB/Swiss-Prot:Q8R480

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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