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    Tfap2c transcription factor AP-2, gamma [ Mus musculus (house mouse) ]

    Gene ID: 21420, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tfap2cprovided by MGI
    Official Full Name
    transcription factor AP-2, gammaprovided by MGI
    Primary source
    MGI:MGI:106032
    See related
    Ensembl:ENSMUSG00000028640 AllianceGenome:MGI:106032
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Stra2; Ap-2.2; Tcfap2c; AP2gamma
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including branch elongation involved in mammary gland duct branching; forebrain development; and keratinocyte development. Located in nucleus. Is expressed in several structures, including early conceptus; embryo ectoderm; embryo mesenchyme; genitourinary system; and retina. Orthologous to human TFAP2C (transcription factor AP-2 gamma). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in placenta adult (RPKM 23.9), CNS E14 (RPKM 3.9) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tfap2c in Genome Data Viewer
    Location:
    2 H3; 2 94.87 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (172387599..172400542)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (172545678..172558622)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 40009 Neighboring gene STARR-seq mESC enhancer starr_06577 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06579 Neighboring gene predicted gene, 35864 Neighboring gene STARR-seq mESC enhancer starr_06580 Neighboring gene STARR-seq mESC enhancer starr_06586 Neighboring gene predicted gene, 35982 Neighboring gene STARR-seq mESC enhancer starr_06588 Neighboring gene predicted gene, 36038 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:172445573-172445774

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcription factor AP-2γ is a core regulator of tight junction biogenesis and cavity formation during mouse early embryogenesis. Choi I, et al. Development, 2012 Dec. PMID 23136388, Free PMC Article
    2. TFAP2C facilitates somatic cell reprogramming by inhibiting c-Myc-dependent apoptosis and promoting mesenchymal-to-epithelial transition. Wang Y, et al. Cell Death Dis, 2020 Jun 25. PMID 32587258, Free PMC Article
    3. Conditional inactivation of transcription factor AP-2gamma by using the Cre/loxP recombination system. Werling U, et al. Genesis, 2002 Feb. PMID 11857798
    4. AP-2γ Is Required for Maintenance of Multipotent Mammary Stem Cells. Gu VW, et al. Stem Cell Reports, 2021 Jan 12. PMID 33382976, Free PMC Article
    5. Transcription factor AP-2gamma stimulates proliferation and apoptosis and impairs differentiation in a transgenic model. Jäger R, et al. Mol Cancer Res, 2003 Oct. PMID 14573793

    See all (129) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tead4 and Tfap2c generate bipotency and a bistable switch in totipotent embryos to promote robust lineage diversification.
      Title: Tead4 and Tfap2c generate bipotency and a bistable switch in totipotent embryos to promote robust lineage diversification.
    2. Defining a TFAP2C-centered transcription factor network during murine peri-implantation.
      Title: Defining a TFAP2C-centered transcription factor network during murine peri-implantation.
    3. Does TFAP2C govern conflicting cell fates in mouse preimplantation embryos?
      Title: Does TFAP2C govern conflicting cell fates in mouse preimplantation embryos?
    4. TFAP2C exacerbates psoriasis-like inflammation by promoting Th17 and Th1 cells activation through regulating TEAD4 transcription.
      Title: TFAP2C exacerbates psoriasis-like inflammation by promoting Th17 and Th1 cells activation through regulating TEAD4 transcription.
    5. HN1L/AP-2gamma/PLK1 signaling drives tumor progression and chemotherapy resistance in esophageal squamous cell carcinoma.
      Title: HN1L/AP-2γ/PLK1 signaling drives tumor progression and chemotherapy resistance in esophageal squamous cell carcinoma.
    6. Constitutive deficiency of the neurogenic hippocampal modulator AP2gamma promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods.
      Title: Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods.
    7. AP-2gamma Is Required for Maintenance of Multipotent Mammary Stem Cells.
      Title: AP-2γ Is Required for Maintenance of Multipotent Mammary Stem Cells.
    8. TFAP2C facilitates somatic cell reprogramming by inhibiting c-Myc-dependent apoptosis and promoting mesenchymal-to-epithelial transition.
      Title: TFAP2C facilitates somatic cell reprogramming by inhibiting c-Myc-dependent apoptosis and promoting mesenchymal-to-epithelial transition.
    9. Developmental clock and mechanism of de novo polarization of the mouse embryo.
      Title: Developmental clock and mechanism of de novo polarization of the mouse embryo.
    10. TFAP2C in trophoblasts controls proliferation by repressing Cdkn1a and activating the MAPK pathway, further supporting differentiation of glycogen cells by activating the AKT pathway
      Title: Tpbpa-Cre-mediated deletion of TFAP2C leads to deregulation of Cdkn1a, Akt1 and the ERK pathway, causing placental growth arrest.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within epithelial cell proliferation involved in mammary gland duct elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within forebrain neuron fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hair follicle development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within keratinocyte development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within sebaceous gland development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within skin development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stem cell population maintenance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within trophectodermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor AP-2 gamma
    Names
    AP2-gamma
    activating enhancer-binding protein 2 gamma
    stimulated by retinoic acid gene 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159696.1 → NP_001153168.1  transcription factor AP-2 gamma isoform 2

      See identical proteins and their annotated locations for NP_001153168.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the presence and absence of exons at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a unique start codon, compared to variant 1. The encoded protein (isoform 2) is longer than isoform 1.
      Source sequence(s)
      AK145603, BQ033542, CJ080187, X94694
      Consensus CDS
      CCDS50810.1
      UniProtKB/TrEMBL
      A2APA8, Q3ULB3
      Related
      ENSMUSP00000129922.2, ENSMUST00000170744.2
      Conserved Domains (1) summary
      pfam03299
      Location:260 → 458
      TF_AP-2; Transcription factor AP-2

    2. NM_009335.2 → NP_033361.2  transcription factor AP-2 gamma isoform 1

      See identical proteins and their annotated locations for NP_033361.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
      Source sequence(s)
      AK145603, BQ033542, BY016798, X94694
      Consensus CDS
      CCDS17135.1
      UniProtKB/Swiss-Prot
      Q61312, Q99L72
      UniProtKB/TrEMBL
      A0A023UF19, Q3URU7
      Related
      ENSMUSP00000030391.3, ENSMUST00000030391.9
      Conserved Domains (1) summary
      pfam03299
      Location:221 → 419
      TF_AP-2; Transcription factor AP-2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      172387599..172400542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499103.5 → XP_006499166.1  transcription factor AP-2 gamma isoform X2

      UniProtKB/TrEMBL
      Q3URU7
      Conserved Domains (1) summary
      pfam03299
      Location:214 → 409
      TF_AP-2; Transcription factor AP-2

    2. XM_017316957.2 → XP_017172446.1  transcription factor AP-2 gamma isoform X3

      UniProtKB/TrEMBL
      Q3URU7
      Conserved Domains (1) summary
      pfam03299
      Location:208 → 403
      TF_AP-2; Transcription factor AP-2

    3. XM_006499102.4 → XP_006499165.1  transcription factor AP-2 gamma isoform X1

      UniProtKB/TrEMBL
      Q3URU7
      Related
      ENSMUST00000128406.8
      Conserved Domains (1) summary
      pfam03299
      Location:229 → 424
      TF_AP-2; Transcription factor AP-2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61312.2 GenPept UniProtKB/Swiss-Prot:Q61312

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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