Hspa5 heat shock protein family A (Hsp70) member 5 [Cricetulus griseus (Chinese hamster)] - Gene

Summary

Gene symbol: Hspa5
Gene description: heat shock protein family A (Hsp70) member 5
Locus tag: I79_019946
See related: Ensembl:ENSCGRG00015003428
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Cricetulus griseus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Also known as: BiP; Grp78; GRP-78
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
104	current	CriGri_1.0 (GCF_000223135.1)	Unplaced Scaffold	NW_003615108.1 (303874..308120)
104	current	CriGri-PICRH-1.0 (GCF_003668045.3)	6	NC_048599.1 (146492189..146496432)

NW_003615108.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MANF contributes to protein folding homeostasis as a nucleotide exchange inhibitor that stabilizes certain BiP-client complexes.
Title: MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP.
These findings suggest a molecular mechanism by which AMPylation serves as a switch to inactivate BiP, limiting its interactions with substrates whilst conserving ATP.
Title: AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
BiP inactivation by AMPylation of its SBD does not disturb Hsp70 inter-domain allostery and preserves BiP structure. Instead it relies on a redistribution of the BiP conformational ensemble and stabilization the domain-docked conformation in presence of ADP and ATP.
Title: Allosteric fine-tuning of the conformational equilibrium poises the chaperone BiP for post-translational regulation.

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General gene information

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Markers

D2Wsu141e (e-PCR), detects polymorphism
- UniSTS:142373

D2Wsu17e (e-PCR), detects polymorphism
- UniSTS:142375

UniSTS:259180 (e-PCR)
- UniSTS:259180

Hspa5 (e-PCR), detects polymorphism
- UniSTS:259180

RH125368 (e-PCR)
- UniSTS:162190

Hspa5 (e-PCR), detects polymorphism
- UniSTS:525967

Hspa5 (e-PCR), detects polymorphism
- UniSTS:143268

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info	PubMed
enables heat shock protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables misfolded protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to unfolded protein	IEA Inferred from Electronic Annotation more info	PubMed
involved_in chaperone cofactor-dependent protein refolding	IEA Inferred from Electronic Annotation more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein refolding	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
part_of endoplasmic reticulum chaperone complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: endoplasmic reticulum chaperone BiP

Names: 78 kDa glucose-regulated protein; Binding-immunoglobulin protein; Endoplasmic reticulum chaperone BiP; HSP70 family protein 5; Heat shock 70 kDa protein 5; Heat shock protein 70 family protein 5; Heat shock protein family A member 5; Immunoglobulin heavy chain-binding protein; glucose-regulated protein; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); heat shock protein 5

NP_001233668.1

EC 3.6.4.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.