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    ZNF226 zinc finger protein 226 [ Homo sapiens (human) ]

    Gene ID: 7769, updated on 2-Nov-2024

    Summary

    Official Symbol
    ZNF226provided by HGNC
    Official Full Name
    zinc finger protein 226provided by HGNC
    Primary source
    HGNC:HGNC:13019
    See related
    Ensembl:ENSG00000167380 AllianceGenome:HGNC:13019
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in prostate (RPKM 5.1), thyroid (RPKM 5.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF226 in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44165100..44199490)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46987958..47000543)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44669253..44681838)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF225 and ZNF224 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:44617263-44617613 Neighboring gene zinc finger protein 225 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44645889-44646479 Neighboring gene zinc finger protein 234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14757 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14759 Neighboring gene zinc finger protein 227 Neighboring gene uncharacterized LOC124904726 Neighboring gene zinc finger protein 233

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in nucleus  

    General protein information

    Preferred Names
    zinc finger protein 226
    Names
    Kruppel-associated box protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032372.2NP_001027544.1  zinc finger protein 226 isoform a

      See identical proteins and their annotated locations for NP_001027544.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, 7, 8, 9, and 10 all encode the same isoform (a).
      Source sequence(s)
      AC138470, AF228418, BC024197, CD700800
      Consensus CDS
      CCDS46102.1
      UniProtKB/Swiss-Prot
      Q8WWE6, Q96TE6, Q9NS44, Q9NYT6
      Related
      ENSP00000393265.1, ENST00000454662.6
      Conserved Domains (5) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:359774
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:365385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:256302
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd20908
      Location:306357
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
    2. NM_001032373.2NP_001027545.1  zinc finger protein 226 isoform a

      See identical proteins and their annotated locations for NP_001027545.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 7, 8, 9, and 10 all encode the same isoform (a).
      Source sequence(s)
      BC024197, CD700800, CF596130
      Consensus CDS
      CCDS46102.1
      UniProtKB/Swiss-Prot
      Q8WWE6, Q96TE6, Q9NS44, Q9NYT6
      Related
      ENSP00000336719.5, ENST00000337433.10
      Conserved Domains (5) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:359774
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:365385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:256302
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd20908
      Location:306357
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
    3. NM_001032374.2NP_001027546.1  zinc finger protein 226 isoform b

      See identical proteins and their annotated locations for NP_001027546.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding region, as well as in the 5' UTR, compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. Variants 3, 4, and 6 all encode isoform b.
      Source sequence(s)
      AC138470, BI457780, BX091242, CF596130
      Consensus CDS
      CCDS46103.1
      UniProtKB/TrEMBL
      B2RBM0, Q9Y2R1
      Related
      ENSP00000407474.1, ENST00000413984.6
      Conserved Domains (1) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
    4. NM_001146220.3NP_001139692.1  zinc finger protein 226 isoform b

      See identical proteins and their annotated locations for NP_001139692.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate 3' exon, compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. Variants 3, 4, and 6 all encode isoform b.
      Source sequence(s)
      AK314724, BC017786, BX537487, DA178589
      Consensus CDS
      CCDS46103.1
      UniProtKB/TrEMBL
      B2RBM0, Q9Y2R1
      Related
      ENSP00000467003.1, ENST00000588742.5
      Conserved Domains (1) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
    5. NM_001319088.2NP_001306017.1  zinc finger protein 226 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 2, 7, 8, 9, and 10 all encode the same isoform (a).
      Source sequence(s)
      BC024197, DA080156, DB015503
      Consensus CDS
      CCDS46102.1
      UniProtKB/Swiss-Prot
      Q8WWE6, Q96TE6, Q9NS44, Q9NYT6
      Conserved Domains (5) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:359774
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:365385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:256302
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd20908
      Location:306357
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
    6. NM_001319089.2NP_001306018.1  zinc finger protein 226 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1, 2, 7, 8, 9, and 10 all encode the same isoform (a).
      Source sequence(s)
      BC024197, DA178589, DA435005
      Consensus CDS
      CCDS46102.1
      UniProtKB/Swiss-Prot
      Q8WWE6, Q96TE6, Q9NS44, Q9NYT6
      Conserved Domains (5) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:359774
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:365385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:256302
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd20908
      Location:306357
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
    7. NM_001319090.2NP_001306019.1  zinc finger protein 226 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1, 2, 7, 8, 9, and 10 all encode the same isoform (a).
      Source sequence(s)
      BC024197, DA178589, DA558473
      Consensus CDS
      CCDS46102.1
      UniProtKB/Swiss-Prot
      Q8WWE6, Q96TE6, Q9NS44, Q9NYT6
      Conserved Domains (5) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:359774
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:365385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:256302
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd20908
      Location:306357
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
    8. NM_001388168.1NP_001375097.1  zinc finger protein 226 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC138470
      Consensus CDS
      CCDS46102.1
      UniProtKB/Swiss-Prot
      Q8WWE6, Q96TE6, Q9NS44, Q9NYT6
      Conserved Domains (5) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:359774
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:365385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:256302
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd20908
      Location:306357
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
    9. NM_001388169.1NP_001375098.1  zinc finger protein 226 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC138470
      Consensus CDS
      CCDS46102.1
      UniProtKB/Swiss-Prot
      Q8WWE6, Q96TE6, Q9NS44, Q9NYT6
      Conserved Domains (5) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:359774
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:365385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:256302
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd20908
      Location:306357
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
    10. NM_001388170.1NP_001375099.1  zinc finger protein 226 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC138470
      Consensus CDS
      CCDS46102.1
      UniProtKB/Swiss-Prot
      Q8WWE6, Q96TE6, Q9NS44, Q9NYT6
      Conserved Domains (5) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:359774
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:365385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:256302
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd20908
      Location:306357
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
    11. NM_001388171.1NP_001375100.1  zinc finger protein 226 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC138470
      Consensus CDS
      CCDS46102.1
      UniProtKB/Swiss-Prot
      Q8WWE6, Q96TE6, Q9NS44, Q9NYT6
      Conserved Domains (5) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:359774
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:365385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:256302
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd20908
      Location:306357
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
    12. NM_001388172.1NP_001375101.1  zinc finger protein 226 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC138470
      Consensus CDS
      CCDS46102.1
      UniProtKB/Swiss-Prot
      Q8WWE6, Q96TE6, Q9NS44, Q9NYT6
      Conserved Domains (5) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:359774
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:365385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:256302
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd20908
      Location:306357
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
    13. NM_001388173.1NP_001375102.1  zinc finger protein 226 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC138470
      Consensus CDS
      CCDS46103.1
      UniProtKB/TrEMBL
      B2RBM0, Q9Y2R1
      Conserved Domains (1) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
    14. NM_001388174.1NP_001375103.1  zinc finger protein 226 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC138470
      Consensus CDS
      CCDS46103.1
      UniProtKB/TrEMBL
      B2RBM0, Q9Y2R1
      Conserved Domains (1) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
    15. NM_001388175.1NP_001375104.1  zinc finger protein 226 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC138470
      Consensus CDS
      CCDS46103.1
      UniProtKB/TrEMBL
      B2RBM0, Q9Y2R1
      Conserved Domains (1) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
    16. NM_001388176.1NP_001375105.1  zinc finger protein 226 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC138470
      Consensus CDS
      CCDS46103.1
      UniProtKB/TrEMBL
      B2RBM0, Q9Y2R1
      Conserved Domains (1) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
    17. NM_001388177.1NP_001375106.1  zinc finger protein 226 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC138470
      Consensus CDS
      CCDS46103.1
      UniProtKB/TrEMBL
      B2RBM0, Q9Y2R1
      Conserved Domains (1) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
    18. NM_001388178.1NP_001375107.1  zinc finger protein 226 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC138470, DA614159, DB117314
      Conserved Domains (4) summary
      COG5048
      Location:323738
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:329349
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:220266
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd20908
      Location:270321
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
    19. NM_015919.4NP_057003.2  zinc finger protein 226 isoform b

      See identical proteins and their annotated locations for NP_057003.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and coding region, as well as in the 5' UTR, compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. Variants 3, 4, and 6 all encode isoform b.
      Source sequence(s)
      AC138470, BI457780, CD700800, CF596130
      Consensus CDS
      CCDS46103.1
      UniProtKB/TrEMBL
      B2RBM0, Q9Y2R1
      Related
      ENSP00000300823.5, ENST00000300823.10
      Conserved Domains (1) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
    20. NM_016444.3NP_057528.2  zinc finger protein 226 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1, 2, 7, 8, 9, and 10 all encode the same isoform (a).
      Source sequence(s)
      AC138470, AF228418, BC024197, DB174587
      Consensus CDS
      CCDS46102.1
      UniProtKB/Swiss-Prot
      Q8WWE6, Q96TE6, Q9NS44, Q9NYT6
      Related
      ENSP00000465121.1, ENST00000590089.5
      Conserved Domains (5) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:359774
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:365385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:256302
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd20908
      Location:306357
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      44165100..44199490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439374.1XP_047295330.1  zinc finger protein 226 isoform X1

      UniProtKB/Swiss-Prot
      Q8WWE6, Q96TE6, Q9NS44, Q9NYT6
    2. XM_006723367.4XP_006723430.1  zinc finger protein 226 isoform X1

      See identical proteins and their annotated locations for XP_006723430.1

      UniProtKB/Swiss-Prot
      Q8WWE6, Q96TE6, Q9NS44, Q9NYT6
      Conserved Domains (5) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:359774
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:365385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:256302
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd20908
      Location:306357
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
    3. XM_006723368.4XP_006723431.1  zinc finger protein 226 isoform X1

      See identical proteins and their annotated locations for XP_006723431.1

      UniProtKB/Swiss-Prot
      Q8WWE6, Q96TE6, Q9NS44, Q9NYT6
      Conserved Domains (5) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:359774
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:365385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:256302
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd20908
      Location:306357
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
    4. XM_047439376.1XP_047295332.1  zinc finger protein 226 isoform X2

    5. XM_017027265.2XP_016882754.1  zinc finger protein 226 isoform X2

      UniProtKB/TrEMBL
      B2RBM0, Q9Y2R1
      Conserved Domains (1) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
    6. XM_047439375.1XP_047295331.1  zinc finger protein 226 isoform X2

    RNA

    1. XR_007066992.1 RNA Sequence

    2. XR_007066995.1 RNA Sequence

    3. XR_007066994.1 RNA Sequence

    4. XR_007066996.1 RNA Sequence

    5. XR_002958356.2 RNA Sequence

    6. XR_007066997.1 RNA Sequence

    7. XR_002958357.2 RNA Sequence

    8. XR_007066998.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      46987958..47000543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322032.1XP_054178007.1  zinc finger protein 226 isoform X1

      UniProtKB/Swiss-Prot
      Q8WWE6, Q96TE6, Q9NS44, Q9NYT6
    2. XM_054322030.1XP_054178005.1  zinc finger protein 226 isoform X1

      UniProtKB/Swiss-Prot
      Q8WWE6, Q96TE6, Q9NS44, Q9NYT6
    3. XM_054322031.1XP_054178006.1  zinc finger protein 226 isoform X1

      UniProtKB/Swiss-Prot
      Q8WWE6, Q96TE6, Q9NS44, Q9NYT6
    4. XM_054322035.1XP_054178010.1  zinc finger protein 226 isoform X2

    5. XM_054322033.1XP_054178008.1  zinc finger protein 226 isoform X2

    6. XM_054322034.1XP_054178009.1  zinc finger protein 226 isoform X2

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