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    FSCN3 fascin actin-bundling protein 3 [ Homo sapiens (human) ]

    Gene ID: 29999, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FSCN3provided by HGNC
    Official Full Name
    fascin actin-bundling protein 3provided by HGNC
    Primary source
    HGNC:HGNC:3961
    See related
    Ensembl:ENSG00000106328 MIM:615800; AllianceGenome:HGNC:3961
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly; cell migration; and establishment or maintenance of cell polarity. Predicted to be located in cytoskeleton. Predicted to be active in several cellular components, including lamellipodium; microvillus; and ruffle. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis (RPKM 43.5) See more
    Orthologs
    mouse all
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    Genomic context

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    See FSCN3 in Genome Data Viewer
    Location:
    7q32.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (127593736..127602144)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (128905415..128913829)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (127233790..127242198)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375490 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:127223080-127224279 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:127224999-127225998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:127227286-127227912 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr7:127227913-127228538 and GRCh37_chr7:127228539-127229165 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:127229166-127229791 Neighboring gene uncharacterized LOC105375489 Neighboring gene GRIP and coiled-coil domain containing 1 Neighboring gene ARF GTPase 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:127249495-127249995 Neighboring gene PAX4 5' regulatory region Neighboring gene paired box 4 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:127291844-127292462 Neighboring gene SND1 divergent transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head. Tubb B, et al. Exp Cell Res, 2002 Apr 15. PMID 11925108
    2. Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes. Tubb BE, et al. Genomics, 2000 Apr 15. PMID 10783262
    3. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. Denoeud F, et al. Genome Res, 2007 Jun. PMID 17567994, Free PMC Article
    4. Human chromosome 7: DNA sequence and biology. Scherer SW, et al. Science, 2003 May 2. PMID 12690205, Free PMC Article
    5. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Maruyama K, et al. Gene, 1994 Jan 28. PMID 8125298

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: ARF5

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cell projection membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in filopodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in growth cone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ruffle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fascin-3
    Names
    fascin actin-bundling protein 3, testicular
    fascin homolog 3, actin-bundling protein, testicular
    testicular secretory protein Li 18
    testis fascin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020369.3 → NP_065102.1  fascin-3

      See identical proteins and their annotated locations for NP_065102.1

      Status: VALIDATED

      Source sequence(s)
      AC073934, AF281049, BC035606
      Consensus CDS
      CCDS34746.1
      UniProtKB/Swiss-Prot
      A4D0Z2, A6NLL7, B2RA62, B4DU68, Q9NQT6
      UniProtKB/TrEMBL
      A0A140VK18
      Related
      ENSP00000265825.5, ENST00000265825.6
      Conserved Domains (2) summary
      cd00257
      Location:386 → 498
      Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
      pfam06268
      Location:271 → 381
      Fascin; Fascin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      127593736..127602144
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      128905415..128913829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NQT6.1 GenPept UniProtKB/Swiss-Prot:Q9NQT6

    Gene LinkOut

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