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    SNX32 sorting nexin 32 [ Homo sapiens (human) ]

    Gene ID: 254122, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SNX32provided by HGNC
    Official Full Name
    sorting nexin 32provided by HGNC
    Primary source
    HGNC:HGNC:26423
    See related
    Ensembl:ENSG00000172803 AllianceGenome:HGNC:26423
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SNX6B
    Summary
    Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in retrograde transport, endosome to Golgi. Predicted to be located in cytosol. Predicted to be active in endosome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in brain (RPKM 2.1), testis (RPKM 1.0) and 7 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SNX32 in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (65833963..65853701)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (65828414..65848170)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65601434..65621172)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:65544816-65545720 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:65547529-65548431 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:65549161-65549818 Neighboring gene adaptor related protein complex 5 subunit beta 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:65553239-65554220 Neighboring gene uncharacterized LOC124902693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5005 Neighboring gene OVOL1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65563211-65563711 Neighboring gene ovo like transcriptional repressor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65565291-65565814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65568897-65569617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5007 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3557 Neighboring gene Sharpr-MPRA regulatory region 4974 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3558 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:65601289-65601501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5009 Neighboring gene Sharpr-MPRA regulatory region 3467 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:65618925-65619786 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5010 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5011 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:65625223-65625763 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5015 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5016 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:65627927-65628466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65629159-65629672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65632825-65633326 Neighboring gene cofilin 1 Neighboring gene MUS81 structure-specific endonuclease subunit Neighboring gene EGF containing fibulin extracellular matrix protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Phox (PX) domain proteins and membrane traffic. Seet LF, et al. Biochim Biophys Acta, 2006 Aug. PMID 16782399
    2. Retromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in Drosophila. Maruzs T, et al. Traffic, 2015 Oct. PMID 26172538
    3. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Michailidou K, et al. Nat Genet, 2013 Apr. PMID 23535729, Free PMC Article
    4. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. Fu GK, et al. Genomics, 2004 Jul. PMID 15203218
    5. rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions. Yang JS, et al. Nat Commun, 2018 Sep 14. PMID 30217970, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ30934, MGC42112, MGC57276, DKFZp761P1320

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of macroautophagy NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-32
    Names
    sorting nexin-6B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152760.3 → NP_689973.2  sorting nexin-32

      See identical proteins and their annotated locations for NP_689973.2

      Status: VALIDATED

      Source sequence(s)
      BC045563, CD638068
      Consensus CDS
      CCDS8113.2
      UniProtKB/Swiss-Prot
      Q86XE0, Q8IW53, Q96NG4
      Related
      ENSP00000310620.6, ENST00000308342.7
      Conserved Domains (2) summary
      cd07621
      Location:180 → 400
      BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
      cl02563
      Location:25 → 163
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      65833963..65853701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      65828414..65848170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86XE0.1 GenPept UniProtKB/Swiss-Prot:Q86XE0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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