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    CNGA4 cyclic nucleotide gated channel subunit alpha 4 [ Homo sapiens (human) ]

    Gene ID: 1262, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CNGA4provided by HGNC
    Official Full Name
    cyclic nucleotide gated channel subunit alpha 4provided by HGNC
    Primary source
    HGNC:HGNC:2152
    See related
    Ensembl:ENSG00000132259 MIM:609472; AllianceGenome:HGNC:2152
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CNG4; CNG5; CNCA2; CNG-4; CNGB2; OCNC2; OCNCb; OCNCBETA
    Summary
    CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in testis (RPKM 2.8), lung (RPKM 0.7) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CNGA4 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (6234793..6244976)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (6293180..6303456)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6260319..6265709)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromosome 11 open reading frame 42 Neighboring gene FHF complex subunit HOOK interacting protein 1B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3097 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3098 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6256113-6256803 Neighboring gene MPRA-validated peak1186 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:6291386-6292585 Neighboring gene cholecystokinin B receptor Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:6324771-6325489 Neighboring gene uncharacterized LOC101927825 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6340407-6341144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4336 Neighboring gene caveolae associated protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation. Munger SD, et al. Science, 2001 Dec 7. PMID 11739959, Free PMC Article
    2. Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice. Kelliher KR, et al. Proc Natl Acad Sci U S A, 2003 Apr 1. PMID 12649326, Free PMC Article
    3. Nomenclature for ion channel subunits. Bradley J, et al. Science, 2001 Dec 7. PMID 11764791, Free PMC Article
    4. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. Hofmann F, et al. Pharmacol Rev, 2005 Dec. PMID 16382102
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC126168, MGC126169

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cAMP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cGMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables intracellularly cAMP-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellularly cGMP-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in monoatomic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi-associated vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in ciliary membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of intracellular cyclic nucleotide activated cation channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in non-motile cilium membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclic nucleotide-gated channel alpha-4
    Names
    CNG channel alpha-4
    cyclic nucleotide gated channel alpha 4
    cyclic nucleotide gated channel beta 2
    cyclic nucleotide-gated cation channel alpha-4
    olfactory cyclic nucleotide-gated channel subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037329.4 → NP_001032406.1  cyclic nucleotide-gated channel alpha-4

      See identical proteins and their annotated locations for NP_001032406.1

      Status: VALIDATED

      Source sequence(s)
      AC022762, AK122736, DB238337
      Consensus CDS
      CCDS31408.1
      UniProtKB/Swiss-Prot
      Q8IV77
      Related
      ENSP00000369268.2, ENST00000379936.3
      Conserved Domains (3) summary
      cd00038
      Location:348 → 464
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:34 → 273
      Ion_trans; Ion transport protein
      pfam16526
      Location:464 → 535
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      6234793..6244976
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017219.2 → XP_016872708.1  cyclic nucleotide-gated channel alpha-4 isoform X2

    2. XM_017017218.3 → XP_016872707.1  cyclic nucleotide-gated channel alpha-4 isoform X2

    3. XM_024448353.2 → XP_024304121.1  cyclic nucleotide-gated channel alpha-4 isoform X3

      Conserved Domains (3) summary
      cd00038
      Location:308 → 424
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:1 → 233
      Ion_trans; Ion transport protein
      pfam16526
      Location:424 → 495
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

    4. XM_017017217.2 → XP_016872706.1  cyclic nucleotide-gated channel alpha-4 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      6293180..6303456
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367688.1 → XP_054223663.1  cyclic nucleotide-gated channel alpha-4 isoform X1

    2. XM_054367691.1 → XP_054223666.1  cyclic nucleotide-gated channel alpha-4 isoform X2

    3. XM_054367689.1 → XP_054223664.1  cyclic nucleotide-gated channel alpha-4 isoform X1

    4. XM_054367690.1 → XP_054223665.1  cyclic nucleotide-gated channel alpha-4 isoform X4

      UniProtKB/Swiss-Prot
      Q8IV77

    5. XM_054367692.1 → XP_054223667.1  cyclic nucleotide-gated channel alpha-4 isoform X2

    6. XM_054367693.1 → XP_054223668.1  cyclic nucleotide-gated channel alpha-4 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IV77.3 GenPept UniProtKB/Swiss-Prot:Q8IV77

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