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    ERCC3 ERCC excision repair 3, TFIIH core complex helicase subunit [ Pongo abelii (Sumatran orangutan) ]

    Gene ID: 100172725, updated on 22-Jun-2024

    Summary

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    Gene symbol
    ERCC3
    Gene description
    ERCC excision repair 3, TFIIH core complex helicase subunit
    Locus tag
    CR201_G0017941
    See related
    Ensembl:ENSPPYG00000012769
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pongo abelii
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
    Orthologs
    human mouse all
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    Genomic context

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    See ERCC3 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2) 11 NC_071996.2 (20598628..20637143)
    RS_2023_04 previous assembly NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1) 2B NC_071987.1 (18004202..18042690)

    Chromosome 11 - NC_071996.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC129057940 Neighboring gene mitogen-activated protein kinase kinase kinase 2 Neighboring gene uncharacterized LOC112132266 Neighboring gene U6 spliceosomal RNA Neighboring gene WW domain-binding protein 11-like Neighboring gene cytochrome P450 27C1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp468A152

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryonic organ development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in hair cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of nucleotide-excision repair factor 3 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of transcription factor TFIIH holo complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of transcription preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    general transcription and DNA repair factor IIH helicase/translocase subunit XPB; general transcription and DNA repair factor IIH helicase subunit XPB
    Names
    DNA 3'-5' helicase/translocase XPB
    DNA excision repair protein ERCC-3
    TFIIH basal transcription factor complex helicase XPB subunit
    TFIIH subunit XPB
    excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)
    NP_001125797.1
    XP_024098702.1
    XP_024098703.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001132325.1 → NP_001125797.1  general transcription and DNA repair factor IIH helicase/translocase subunit XPB

      See identical proteins and their annotated locations for NP_001125797.1

      Status: PROVISIONAL

      Source sequence(s)
      CR859159
      UniProtKB/Swiss-Prot
      Q5RA62
      Related
      ENSPPYP00000014246.2, ENSPPYT00000014826.2
      Conserved Domains (4) summary
      TIGR00603
      Location:60 → 779
      rad25; DNA repair helicase rad25
      pfam04851
      Location:315 → 472
      ResIII; Type III restriction enzyme, res subunit
      pfam13625
      Location:76 → 198
      Helicase_C_3; Helicase conserved C-terminal domain
      pfam16203
      Location:496 → 739
      ERCC3_RAD25_C; ERCC3/RAD25/XPB C-terminal helicase

    RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

    Genomic

    1. NC_071996.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

      Range
      20598628..20637143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024242935.3 → XP_024098703.1  general transcription and DNA repair factor IIH helicase subunit XPB isoform X1

      Conserved Domains (1) summary
      TIGR00603
      Location:1 → 715
      rad25; DNA repair helicase rad25

    2. XM_024242934.3 → XP_024098702.1  general transcription and DNA repair factor IIH helicase subunit XPB isoform X1

      Conserved Domains (1) summary
      TIGR00603
      Location:1 → 715
      rad25; DNA repair helicase rad25
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RA62.1 GenPept UniProtKB/Swiss-Prot:Q5RA62

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