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    pyk-1 Pyruvate kinase [ Caenorhabditis elegans ]

    Gene ID: 172744, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pyk-1
    Official Full Name
    Pyruvate kinase
    Primary source
    WormBase:WBGene00009126
    Locus tag
    CELE_F25H5.3
    See related
    AllianceGenome:WB:WBGene00009126
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable pyruvate kinase activity. Predicted to be involved in glycolytic process. Predicted to be active in cytoplasm. Is expressed in body wall musculature and reproductive system. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; pyruvate kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to several human genes including PKM (pyruvate kinase M1/2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See pyk-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (9168432..9177488)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Claspin Neighboring gene Elongation factor 2 Neighboring gene ncRNA Neighboring gene Plasma membrane proteolipid 3 Neighboring gene ncRNA Neighboring gene Transmembrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bacteria pyruvate metabolism modulates AFB(1) toxicity in Caenorhabditis elegans. Tang B, et al. Sci Total Environ, 2023 Nov 20. PMID 37506907
    2. Reciprocal Changes in Phosphoenolpyruvate Carboxykinase and Pyruvate Kinase with Age Are a Determinant of Aging in Caenorhabditis elegans. Yuan Y, et al. J Biol Chem, 2016 Jan 15. PMID 26631730, Free PMC Article
    3. From the Cover: Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-like Effect in Caenorhabditis elegans. Luz AL, et al. Toxicol Sci, 2016 Aug. PMID 27208080, Free PMC Article
    4. Phenolic acid metabolites of polyphenols act as inductors for hormesis in C. elegans. Dilberger B, et al. Mech Ageing Dev, 2021 Sep. PMID 34139214
    5. An anchored experimental design and meta-analysis approach to address batch effects in large-scale metabolomics. Shaver AO, et al. Front Mol Biosci, 2022. PMID 36438654, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Pyruvate kinase
    NP_001021412.1
    • Confirmed by transcript evidence
    NP_001379415.1
    • Confirmed by transcript evidence
    NP_001379495.1
    • Confirmed by transcript evidence
    NP_492458.1
    • Confirmed by transcript evidence
    NP_492459.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9168432..9177488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060057.7 → NP_492458.1  Pyruvate kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492458.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17836
      Conserved Domains (2) summary
      TIGR01064
      Location:78 → 558
      pyruv_kin; pyruvate kinase
      cl23794
      Location:78 → 561
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

    2. NM_001026241.7 → NP_001021412.1  Pyruvate kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021412.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q3S1I8
      Conserved Domains (2) summary
      TIGR01064
      Location:74 → 554
      pyruv_kin; pyruvate kinase
      cl23794
      Location:74 → 557
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

    3. NM_001392780.1 → NP_001379495.1  Pyruvate kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7WNA0
      Conserved Domains (1) summary
      cd00288
      Location:429 → 912
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

    4. NM_001392781.1 → NP_001379415.1  Pyruvate kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JL40
      Conserved Domains (1) summary
      cl39076
      Location:47 → 530
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

    5. NM_060058.5 → NP_492459.1  Pyruvate kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492459.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17835
      Conserved Domains (2) summary
      TIGR01064
      Location:116 → 596
      pyruv_kin; pyruvate kinase
      cl23794
      Location:116 → 599
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    Nucleotide Protein
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