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    amx-1 Lysine-specific histone demethylase 1B homolog [ Caenorhabditis elegans ]

    Gene ID: 175493, updated on 2-Nov-2024

    Summary

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    Official Symbol
    amx-1
    Official Full Name
    Lysine-specific histone demethylase 1B homolog
    Primary source
    WormBase:WBGene00000137
    Locus tag
    CELE_R13G10.2
    See related
    AllianceGenome:WB:WBGene00000137
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables FAD-dependent H3K4me/H3K4me3 demethylase activity. Predicted to be involved in epigenetic regulation of gene expression. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in chemosensory neurons. Orthologous to human KDM1B (lysine demethylase 1B). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See amx-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (3822403..3826260)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Chromosome condensation protein dpy-27 Neighboring gene ncRNA Neighboring gene Metal transporter cnnm-5 Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene Cytochrome P450

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Histone Demethylase AMX-1 Regulates Fertility in a p53/CEP-1 Dependent Manner. Ren X, et al. Front Genet, 2022. PMID 35846143, Free PMC Article
    2. Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage. Zhang X, et al. PLoS Genet, 2021 Jul. PMID 34329293, Free PMC Article
    3. A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory. Katz DJ, et al. Cell, 2009 Apr 17. PMID 19379696, Free PMC Article
    4. C. elegans: a novel pharmacogenetic model to study Parkinson's disease. Nass R, et al. Parkinsonism Relat Disord, 2001 Jul. PMID 11331185
    5. SAMS-1 coordinates HLH-30/TFEB and PHA-4/FOXA activities through histone methylation to mediate dietary restriction-induced autophagy and longevity. Lim CY, et al. Autophagy, 2023 Jan. PMID 35503435, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage.
      Title: Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables FAD-dependent H3K4me/H3K4me3 demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FAD-dependent H3K4me/H3K4me3 demethylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD-dependent H3K4me/H3K4me3 demethylase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epigenetic regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Lysine-specific histone demethylase 1B homolog
    NP_497772.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      3822403..3826260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065371.7 → NP_497772.2  Lysine-specific histone demethylase 1B homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497772.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21988
      Conserved Domains (3) summary
      pfam01593
      Location:361 → 813
      Amino_oxidase; Flavin containing amine oxidoreductase
      pfam04433
      Location:251 → 337
      SWIRM; SWIRM domain
      pfam13450
      Location:356 → 414
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21988.3

    Gene LinkOut

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