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    Y38F2AR.12 5-oxoprolinase;Hydantoinase B/oxoprolinase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 189679, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Y38F2AR.12
    Official Full Name
    5-oxoprolinase;Hydantoinase B/oxoprolinase domain-containing protein
    Primary source
    WormBase:WBGene00021430
    Locus tag
    CELE_Y38F2AR.12
    See related
    AllianceGenome:WB:WBGene00021430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 5-oxoprolinase (ATP-hydrolyzing) activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytosol. Orthologous to human OPLAH (5-oxoprolinase, ATP-hydrolysing). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See Y38F2AR.12 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    14
    Sequence:
    Chromosome: IV; NC_003282.8 (2399484..2412420, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein;Tudor domain-containing protein Neighboring gene ncRNA Neighboring gene Major sperm protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RING-type domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    2. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 5-oxoprolinase (ATP-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    5-oxoprolinase;Hydantoinase B/oxoprolinase domain-containing protein
    NP_001076725.2
    • Confirmed by transcript evidence
    NP_001294530.1
    • Confirmed by transcript evidence
    NP_001379804.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2399484..2412420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001083256.4 → NP_001076725.2  5-oxoprolinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076725.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A9S2
      Conserved Domains (1) summary
      PLN02666
      Location:1 → 1255
      PLN02666; 5-oxoprolinase

    2. NM_001392265.1 → NP_001379804.1  Hydantoinase B/oxoprolinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86FM9
      Conserved Domains (1) summary
      PLN02666
      Location:23 → 514
      PLN02666; 5-oxoprolinase

    3. NM_001307601.3 → NP_001294530.1  5-oxoprolinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294530.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PMK1
      Conserved Domains (1) summary
      PLN02666
      Location:1 → 941
      PLN02666; 5-oxoprolinase
    Nucleotide Protein
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