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    mcu-1 Calcium uniporter protein, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 177362, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mcu-1
    Official Full Name
    Calcium uniporter protein, mitochondrial
    Primary source
    WormBase:WBGene00019296
    Locus tag
    CELE_K02B2.3
    See related
    AllianceGenome:WB:WBGene00019296
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables calcium channel activity and identical protein binding activity. Involved in several processes, including calcium import into the mitochondrion; mitochondrial calcium ion homeostasis; and protein homooligomerization. Predicted to be located in mitochondrial inner membrane. Predicted to be part of uniplex complex. Orthologous to several human genes including MCU (mitochondrial calcium uniporter). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See mcu-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (5937447..5939230, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Cat eye syndrome critical region protein 5;Host attachment protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Fructose-2,6-bisphosphatase Neighboring gene ncRNA Neighboring gene Innexin;Innexin-7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans epidermal wounding induces a mitochondrial ROS burst that promotes wound repair. Xu S, et al. Dev Cell, 2014 Oct 13. PMID 25313960, Free PMC Article
    2. Architecture of the mitochondrial calcium uniporter. Oxenoid K, et al. Nature, 2016 May 12. PMID 27135929, Free PMC Article
    3. Ion and inhibitor binding of the double-ring ion selectivity filter of the mitochondrial calcium uniporter. Cao C, et al. Proc Natl Acad Sci U S A, 2017 Apr 4. PMID 28325874, Free PMC Article
    4. Mitochondrial Ca(2+) Dynamics in MCU Knockout C. elegans Worms. Álvarez-Illera P, et al. Int J Mol Sci, 2020 Nov 16. PMID 33207633, Free PMC Article
    5. Microbiota and Diapause-Induced Neuroprotection Share a Dependency on Calcium But Differ in Their Effects on Mitochondrial Morphology. Delgado SE, et al. eNeuro, 2023 Jul. PMID 37385728, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mitochondrial calcium uniporter (MCU) activates mitochondrial respiration and enhances mobility by regulating mitochondrial redox state.
      Title: The mitochondrial calcium uniporter (MCU) activates mitochondrial respiration and enhances mobility by regulating mitochondrial redox state.
    2. Mitochondrial Ca(2+) Dynamics in MCU Knockout C. elegans Worms.
      Title: Mitochondrial Ca(2+) Dynamics in MCU Knockout C. elegans Worms.
    3. Mn2+ binds specifically to the MCU protein DXXE motif, which can be displaced by Ca2+.
      Title: Ion and inhibitor binding of the double-ring ion selectivity filter of the mitochondrial calcium uniporter.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables uniporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium import into the mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of reactive oxygen species biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of uniplex complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Calcium uniporter protein, mitochondrial
    NP_500892.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      5937447..5939230 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068491.7 → NP_500892.1  Calcium uniporter protein, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500892.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21121
      Conserved Domains (1) summary
      pfam04678
      Location:93 → 299
      MCU; Mitochondrial calcium uniporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21121.2

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