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    ham-1 Stork-head box protein ham-1 [ Caenorhabditis elegans ]

    Gene ID: 178205, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ham-1
    Official Full Name
    Stork-head box protein ham-1
    Primary source
    WormBase:WBGene00001820
    Locus tag
    CELE_F53B2.6
    See related
    AllianceGenome:WB:WBGene00001820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including asymmetric protein localization involved in cell fate determination; generation of neurons; and protein localization to actomyosin contractile ring. Located in cell cortex and nucleus. Is expressed in several structures, including anal region; digestive tract; gonad; head; and midbody. Human ortholog(s) of this gene implicated in pre-eclampsia. Orthologous to several human genes including STOX1 (storkhead box 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ham-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (12542183..12545737)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Kinase Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans gene ham-1 regulates daughter cell size asymmetry primarily in divisions that produce a small anterior daughter cell. Teuliere J, et al. PLoS One, 2018. PMID 29668718, Free PMC Article
    2. C. elegans HAM-1 functions in the nucleus to regulate asymmetric neuroblast division. Leung A, et al. Dev Biol, 2016 Feb 1. PMID 26703426
    3. A proneural gene controls C. elegans neuroblast asymmetric division and migration. Zhu Z, et al. FEBS Lett, 2014 Apr 2. PMID 24589937
    4. C. elegans HAM-1 positions the cleavage plane and regulates apoptosis in asymmetric neuroblast divisions. Frank CA, et al. Dev Biol, 2005 Aug 15. PMID 15979607
    5. Comparative genetic, proteomic and phosphoproteomic analysis of C. elegans embryos with a focus on ham-1/STOX and pig-1/MELK in dopaminergic neuron development. Offenburger SL, et al. Sci Rep, 2017 Jun 28. PMID 28659600, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. While ham-1 function is essential for asymmetric division in the lineage that generates the PLM mechanosensory neuron, we showed that cortical localization may not required
      Title: C. elegans HAM-1 functions in the nucleus to regulate asymmetric neuroblast division.
    2. TBX-2, along with HAM-1, regulates the migrations of the HSN motor neurons and prevents the PHB sensory neurons from adopting an apoptotic fate.
      Title: The T-box gene tbx-2, the homeobox gene egl-5 and the asymmetric cell division gene ham-1 specify neural fate in the HSN/PHB lineage.
    3. Ham-1 positions the cleavage plane and regulates apoptosis in asymmetric neuroblast divisions.
      Title: C. elegans HAM-1 positions the cleavage plane and regulates apoptosis in asymmetric neuroblast divisions.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in asymmetric neuroblast division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in asymmetric neuroblast division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in asymmetric protein localization involved in cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dopaminergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to actomyosin contractile ring IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spindle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Stork-head box protein ham-1
    NP_502401.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12542183..12545737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070000.8 → NP_502401.1  Stork-head box protein ham-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502401.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEC5
      Conserved Domains (1) summary
      pfam10264
      Location:93 → 169
      Stork_head; Winged helix Storkhead-box1 domain
    Nucleotide Protein
    Heading Accession and Version

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