gly-13 Putative alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gly-13
Official Full Name: Putative alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Primary source: WormBase:WBGene00001638
Locus tag: CELE_B0416.6
See related: AllianceGenome:WB:WBGene00001638
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Located in perinuclear region of cytoplasm. Is expressed in several structures, including ganglia; intestine; muscle cell; ventral nerve cord; and vulva. Orthologous to human MGAT1 (alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gly-13 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 12

Sequence:: Chromosome: X; NC_003284.9 (9293666..9296622, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

60% of the mutants lacking the gly-13 gene arrested as L1 larvae at 20 degrees C
Title: Isolation of null alleles of the Caenorhabditis elegans gly-12, gly-13 and gly-14 genes, all of which encode UDP-GlcNAc: alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I activity.
A worm with null mutations in all three GnT I genes, gly-14, gly-12, & gly-13; worm extracts do not express GnT I activity and have a markedly abnormal N-glycan pattern.
Title: Caenorhabditis elegans triple null mutant lacking UDP-N-acetyl-D-glucosamine:alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0416.6 (e-PCR)
- UniSTS:313404

B0416.7 (e-PCR)
- UniSTS:315331

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acetylglucosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
NOT involved_in regulation of alpha-(1->3)-fucosyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi medial cisterna	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Putative alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

NP_509566.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

9293666..9296622 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077165.8 → NP_509566.1 Putative alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509566.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76776, Q11068

Conserved Domains (1) summary

cl11394
Location:1 → 441

Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold