Acsl5 acyl-CoA synthetase long-chain family member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acsl5provided by RGD
Official Full Name: acyl-CoA synthetase long-chain family member 5provided by RGD
Primary source: RGD:69402
See related: EnsemblRapid:ENSRNOG00000016265 AllianceGenome:RGD:69402
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Acs5; Facl5
Summary: Enables arachidonate-CoA ligase activity. Involved in several processes, including organophosphate biosynthetic process; positive regulation of lipid metabolic process; and positive regulation of long-chain fatty acid import across plasma membrane. Predicted to be located in nucleolus; nucleoplasm; and plasma membrane. Predicted to be active in endoplasmic reticulum; membrane; and mitochondrion. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human ACSL5 (acyl-CoA synthetase long chain family member 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 1524.8), Lung (RPKM 491.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q55

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (264294851..264341943)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (254289513..254336608)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (276240703..276290012)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data strongly indicate that human but not rat acyl-CoA synthetase 5 is sensitive to triacsin C and does not compensate for other triacsin C-sensitive ACSL isoforms.
Title: Human intestinal acyl-CoA synthetase 5 is sensitive to the inhibitor triacsin C.
ACSL5 activates and channels fatty acids toward anabolic pathways
Title: Hepatic long-chain acyl-CoA synthetase 5 mediates fatty acid channeling between anabolic and catabolic pathways.
uptake of fatty acids into cells is regulated by metabolism and overexpressed ACSL5 partitions exogenously derived fatty acids toward TAG synthesis and storage
Title: Rat long chain acyl-CoA synthetase 5 increases fatty acid uptake and partitioning to cellular triacylglycerol in McArdle-RH7777 cells.

Submit: New GeneRIF Correction

General gene information

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Markers

RH132400 (e-PCR)
- UniSTS:215683

D1Rat456 (e-PCR), detects polymorphism
- UniSTS:227238

BE097769 (e-PCR)
- UniSTS:260783

Acsl5 (e-PCR), detects polymorphism
- UniSTS:502705

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables arachidonate-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonate-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables long-chain fatty acid-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables long-chain fatty acid-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid-CoA ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables long-chain fatty acid-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables oleoyl-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables oleoyl-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables oleoyl-CoA ligase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in fatty acid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in fatty acid transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty-acyl-CoA biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty-acyl-CoA biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phospholipid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of fatty acid beta-oxidation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of long-chain fatty acid import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of long-chain fatty acid import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of triglyceride biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to cholesterol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to sucrose	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: long-chain-fatty-acid--CoA ligase 5

Names: LACS 5; arachidonate--CoA ligase; fatty acid Coenzyme A ligase, long chain 5; long-chain acyl-CoA synthetase 5; long-chain fatty acid coenzyme A ligase 5

NP_446059.2

EC 6.2.1.15

EC 6.2.1.3

XP_038949085.1

EC 6.2.1.15

EC 6.2.1.3

XP_038949096.1

EC 6.2.1.15

EC 6.2.1.3

XP_038949101.1

EC 6.2.1.15

EC 6.2.1.3

XP_038949105.1

EC 6.2.1.15

EC 6.2.1.3

XP_063132073.1

EC 6.2.1.15

EC 6.2.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053607.2 → NP_446059.2 long-chain-fatty-acid--CoA ligase 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

O88813

UniProtKB/TrEMBL

A6JHY8, A6JHY9, Q6IN15

Related

ENSRNOP00000078386.1, ENSRNOT00000109824.2

Conserved Domains (1) summary

cd05927
Location:101 → 678

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

264294851..264341943

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063276003.1 → XP_063132073.1 long-chain-fatty-acid--CoA ligase 5 isoform X4

Related

ENSRNOP00000080415.2, ENSRNOT00000110033.2
XM_039093168.2 → XP_038949096.1 long-chain-fatty-acid--CoA ligase 5 isoform X1

UniProtKB/Swiss-Prot

O88813

UniProtKB/TrEMBL

A6JHY8, A6JHY9, Q6IN15

Conserved Domains (1) summary

cd05927
Location:101 → 678

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
XM_039093157.2 → XP_038949085.1 long-chain-fatty-acid--CoA ligase 5 isoform X1

UniProtKB/Swiss-Prot

O88813

UniProtKB/TrEMBL

A6JHY8, A6JHY9, Q6IN15

Related

ENSRNOP00000022126.8, ENSRNOT00000022126.8

Conserved Domains (1) summary

cd05927
Location:101 → 678

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
XM_039093177.2 → XP_038949105.1 long-chain-fatty-acid--CoA ligase 5 isoform X3

UniProtKB/Swiss-Prot

O88813

Conserved Domains (1) summary

cd05927
Location:78 → 655

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
XM_039093173.2 → XP_038949101.1 long-chain-fatty-acid--CoA ligase 5 isoform X2

UniProtKB/Swiss-Prot

O88813

Conserved Domains (1) summary

cd05927
Location:96 → 673

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)